A5013368794- Adolescent Sexual and Reproductive Health
- HIV/AIDS Research and Interventions
- Reproductive tract infections research
- HIV Research and Treatment
- Global Maternal and Child Health
- Syphilis Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- Occupational and environmental lung diseases
- Reproductive Health and Contraception
- Immune Cell Function and Interaction
- Carcinogens and Genotoxicity Assessment
- Cervical Cancer and HPV Research
- Air Quality and Health Impacts
- Sex work and related issues
- HIV/AIDS Impact and Responses
- Cancer Risks and Factors
- Noise Effects and Management
- Intimate Partner and Family Violence
- Multiple Myeloma Research and Treatments
- T-cell and B-cell Immunology
- Nutritional Studies and Diet
- HIV-related health complications and treatments
- Folate and B Vitamins Research
- Obesity, Physical Activity, Diet
- HIV/AIDS drug development and treatment
University of Alabama at Birmingham
2012-2024
UiT The Arctic University of Norway
2024
University of Alabama at Birmingham Hospital
2022
Rwanda Zambia HIV Research Group
2012-2018
Emory University
2012-2018
John Wiley & Sons (United States)
2016
RELX Group (United States)
2015
Government of the United States of America
2015
United States Agency for International Development
2015
AID Atlanta
2015
Prior improvements in multiple myeloma (MM) survival were not fully observed racial and ethnic minorities older individuals. We hypothesized that MM management recent years have reduced these disparities. used the Surveillance, Epidemiology, End Results registries to calculate incidence relative rates (RSRs) of United States for patients diagnosed from 1993 1997 (prethalidomide), 1998 2002 (introduction thalidomide), 2003 2007 (bortezomib lenalidomide), 2008 2012 (upfront bortezomib...
BACKGROUND: Smoking cessation reduces mortality and morbidity. However, the extent rapidity at which contemporary death rates from smoking-related illnesses remain uncertain. METHODS: We pooled current or former versus never cigarette smoker hazard ratios four national cohorts with linkage to registries in United States, Kingdom, Norway, Canada among adults 20 79 years of age 1974 2018. calculated excess risk differences survival, comparing smokers age-specific fewer than 3, 3 9, 10 more...
Background We examined relationships between schistosome infection, HIV transmission or acquisition, and all-cause death. Methods retrospectively tested baseline sera from a heterosexual HIV-discordant couple cohort in Lusaka, Zambia with follow-up 1994–2012 nested case-control design. Schistosome-specific antibody levels were measured by ELISA. Associations response to antigens incident transmission, death stratified gender status assessed. In subset of HIV- women HIV+ men, we performed...
BACKGROUND Recent advances in the treatment of multiple myeloma (MM) have been associated with improved survival, predominantly among young and white patients. The authors hypothesized that sociodemographic factors, adjusted for race/ethnicity, influence survival younger patients MM. METHODS Overall (OS) data were obtained individuals included Surveillance, Epidemiology, End Results (SEER‐18) program who diagnosed MM before age 65 years between 2007 2012. variables addressed marital status,...
OBJECTIVES: This study evaluated a behavioral intervention designed to promote female condoms and reduce unprotected sex among women at high risk for acquiring sexually transmitted diseases (STDs). METHODS: The effect of the on barrier use was with pretest-posttest design 1159 STD clinic patients. RESULTS: Among participants follow-up data, 79% used condom least once often multiple times. More than one third those who completed throughout follow-up. Use protection increased significantly...
HIV epidemiology informs prevention trial design and program planning. Nine clinical research centers (CRC) in sub-Saharan Africa conducted observational studies populations at risk for infection as part of an vaccine network. Annual incidence ranged from below 2% to above 10% varied by CRC group, with rates 5% observed Zambian men HIV-discordant relationship, Ugandan Lake Victoria fishing communities, who have sex men, several cohorts women. tended fall after the first three months study...
Abstract New data regarding a positive association between smoking and risk of epithelial ovarian cancer (EOC), especially the mucinous tumor type, has started to emerge. The purpose this study was examine different measures exposures subtypes EOC in large cohort women from 10 European countries. Prospective Investigation into Cancer Nutrition (EPIC) is multicenter prospective initiated 1992. questionnaires included about dietary, lifestyle, health factors. Information cigarette collected...
Multiple myeloma (MM) is the most common hematologic malignancy affecting Blacks in USA, with standardized incidence rates that are twofold to threefold higher than Whites. The rationale for disparity unclear. Using participants enrolled Molecular And Genetic Epidemiology study of (259 MM cases; 461 controls), we examined risk associated family history cancer, differences by race and among cases, defining clinical features. Risk estimates were calculated using odds ratios corresponding 95%...
<h3>Background</h3> We present temporal trends in self-reported and biological markers of unprotected sex with concurrent partners discordant couples receiving couples9 voluntary HIV counselling testing (CVCT). <h3>Methods</h3> Heterosexual Zambian HIV-serodiscordant were enrolled into longitudinal follow-up an open cohort (1994–2012). Multivariable Anderson-Gill models explored predictors self-report indicators within (including sperm on a vaginal swab, incident pregnancy or linked...
We evaluated the relation between work experience in United States operations of an electronics company and brain tumor mortality, focusing on video display terminal (VDT) development jobs. Subjects were 149 cases 591 matched controls selected from a registry all employees dying 1975 1989. Company databases interviews with personnel constituted basis for histories, including information whether subjects had held VDT who worked at plants hardware or slightly but imprecisely elevated odds...
This analysis examined how unmeasured confounding affects estimates of the effectiveness condoms in preventing sexually transmitted infections. Data were analyzed from a prospective cohort study 1,122 female disease clinic patients Alabama (1992-1995), wherein participants evaluated for infections at six 1-month intervals. Associations between condom use and incident gonorrhea chlamydia infection compared case-crossover analyses. In 228 follow-up visits ending gonorrhea/chlamydia ("case...
Biased enrollment and attrition compromise the power of clinical trials limit generalizability findings. We identify predictors retention for HIV-discordant couples enrolled in prospective studies Zambia.A total 1995 discordant were invited to enroll. Predictors nonenrollment, loss follow-up, missed appointments evaluated using multivariate models. MF more likely be eligible enroll less lost follow-up than FM couples. Substantial losses occurred between testing (21.3% 28.1% FM) first visit...
Abstract Differences in immune control of HIV-1 infection are often attributable to the highly variable HLA class I molecules that present viral epitopes CTL. In our immunogenetic analyses 429 discordant Zambian couples (infected index partners paired with cohabiting seronegative partners), several variants were associated contrasting rates and incidence transmission within a 12-year study period. particular, A*3601 on A*36-Cw*04-B*53 haplotype was most unfavorable marker by partners, while...
Objective: To describe predictors of contraceptive method discontinuation and switching behaviours among HIV-positive couples receiving couples' voluntary HIV counselling testing services in Lusaka, Zambia. Design: Couples were randomized a factorial design to two-family planning educational intervention videos, received comprehensive family assessed every 3 months for initiation, switching. Methods: We modelled factors associated with upgrading downgrading via multivariate Andersen–Gill...
This study evaluated mortality among workers at a talc mining and milling facility.Subjects were white men actively employed between 1948 1989 known to have been alive in or after 1950. Analyses assessed cancer during the period 1950-89 (809 subjects) non-cancer 1960-89 (782 subjects).Comparisons with regional general population death rates for indicated that had more than expected deaths from all causes combined [209 observed/160 expected, standardized ratio (SMR) = 131, 95% confidence...
During untreated, chronic HIV-1 infection, plasma viral load (VL) is a relatively stable quantitative trait that has clinical and epidemiological implications. Immunogenetic research established various human genetic factors, especially leukocyte antigen (HLA) variants, as independent determinants of VL set-point.To identify clarify HLA alleles are associated with either transient or durable immune control we evaluated the relationships class I II among 563 seroprevalent Zambians (SPs) who...
Studies have demonstrated the role of ulcerative and non-ulcerative sexually transmitted infections (STI) in HIV transmission/acquisition risk; less is understood about non-specific inflammatory genital abnormalities.
Background Acquisition of human immunodeficiency virus type 1 (HIV-1) infection is mediated by a combination characteristics the infectious and susceptible member transmission pair, including behavioral genetic factors, as well viral fitness tropism. Here we report on impact established potential new HLA class I determinants heterosexual HIV-1 acquisition in HIV-1-exposed seronegative (HESN) partners serodiscordant Zambian couples. Methodology/Principal Findings We assessed relationships...
Polymorphisms in chemokine (C-C motif) receptors 2 and 5 genes (CCR2 CCR5) have been associated with HIV-1 infection disease progression. We investigated the impact of CCR2-CCR5 haplotypes on viral load (VL) heterosexual transmission an African cohort. Between 1995 2006, cohabiting Zambian couples discordant for (index seropositive exposed seronegative {HESN}) were monitored prospectively to determine role host genetic factors control transmission. Genotyping eight CCR2 CCR5 variants...