A5054202053- Advanced Causal Inference Techniques
- Statistical Methods and Inference
- Statistical Methods and Bayesian Inference
- Health Systems, Economic Evaluations, Quality of Life
- Health disparities and outcomes
- Statistical Methods in Clinical Trials
- Air Quality and Health Impacts
- Inflammatory Bowel Disease
- Urban Transport and Accessibility
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Microscopic Colitis
- Global Cancer Incidence and Screening
- Smoking Behavior and Cessation
- Economic and Financial Impacts of Cancer
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Immune Cell Function and Interaction
- Bladder and Urothelial Cancer Treatments
- Bayesian Modeling and Causal Inference
- Healthcare Policy and Management
- Bayesian Methods and Mixture Models
- Stoma care and complications
- Sex work and related issues
Rutgers, The State University of New Jersey
2021-2025
Manufacturing Institute
2023
Icahn School of Medicine at Mount Sinai
2017-2022
Rutgers Sexual and Reproductive Health and Rights
2021-2022
Propagation des Ondes : Étude Mathématique et Simulation
2022
Tisch Hospital
2020-2021
Tisch Cancer Institute
2018-2021
Mount Sinai Health System
2020-2021
University of Science and Technology Beijing
2020
Mount Sinai Hospital
2020
Cancers infiltrated with T-cells are associated a higher likelihood of response to PD-1/PD-L1 blockade. Counterintuitively, correlation between epithelial-mesenchymal transition (EMT)-related gene expression and T-cell infiltration has been observed across tumor types. Here we demonstrate, using The Cancer Genome Atlas (TCGA) urothelial cancer dataset, that although expression-based measure infiltrating abundance EMT-related positively correlated, these signatures convey disparate prognostic...
This study examined the role of self-efficacy and physical function performance in relationship between activity functional limitations. Older women (age, M = 68.2 years) completed measures activity, self-efficacy, performance, limitations at baseline an ongoing study. Analyses indicated that was associated with for exercise, efficacy gait balance, performance. Both were Demographic health status variables did not differentially influence these relationships. Although cross-sectional nature,...
Purpose There are no randomized trials to guide treatment decisions between radiotherapeutic and surgical options for patients with high-risk localized prostate cancer. Comparative studies have been limited by their ability match on the basis of pretreatment prognostic variables adjust cancer-related, medical, socioeconomic differences who choose or approaches. Methods We analyzed outcome all in National Cancer Database high-risk, clinically cancer complete data were treated either radical...
There is a dearth of robust methods to estimate the causal effects multiple treatments when outcome binary. This paper uses two unique sets simulations propose and evaluate use Bayesian additive regression trees in such settings. First, we compare several approaches that have been proposed for continuous outcomes, including inverse probability treatment weighting, targeted maximum likelihood estimator, vector matching, adjustment. Results suggest under conditions non-linearity non-additivity...
Historical redlining was a discriminatory housing policy that placed financial services beyond the reach of residents in inner-city communities. The extent impact this on contemporary health outcomes remains to be elucidated.To evaluate associations among historical redlining, social determinants (SDOH), and community-level stroke prevalence New York City.An ecological, retrospective, cross-sectional study conducted using City data from January 1, 2014, December 31, 2018. Data...
Differences in autonomic nervous system function, measured by heart rate variability (HRV), have been observed between patients with inflammatory bowel disease and healthy control associated cross-sectional studies systemic inflammation. High HRV has low stress.Patients ulcerative colitis (UC) were followed for 9 months. Their was every 4 weeks using the VitalPatch, blood collected at baseline 12 assessing cortisol, adrenocorticotropin hormone, interleukin-1β, interleukin-6, tumor necrosis...
Background Street-connected youth are a neglected and vulnerable population, particularly in resource-constrained settings. The development of interventions supports for this population requires insight into how they live. This study describes the social economic characteristics convenience sample street (SY) Eldoret, Kenya. Methods Participants were eligible if aged 12–21, living spending days only (part-time), or nights on (full-time) able willing to consent assent. Data collected using...
Abstract Background The Oncology Care Model (OCM) was developed as a payment model to encourage participating practices provide better-quality care for cancer patients at lower cost. risk-adjustment used in OCM is Gamma generalized linear (Gamma GLM) with log-link. predicted value of expense the episodes identified our academic medical center (AMC), based on fitted national data, did not correlate well observed expense. This motivated us fit GLM AMC data and compare it two other flexible...
Summary Background There is a need for improved risk stratification in Crohn's disease. Aim To identify novel blood protein biomarkers associated with future disease complications Methods We performed case‐cohort study utilising paediatric inception cohort, the Risk Stratification and Identification of Immunogenetic Microbial Markers Rapid Disease Progression Children (RISK) study. All patients had inflammatory (B1) at baseline. Outcomes were development stricturing (B2) or penetrating (B3)...
Background Stroke is a major cardiovascular disease that causes significant health and economic burden in the United States. Neighborhood community-based interventions have been shown to be both effective cost-effective preventing disease. There dearth of robust studies identifying key determinants underlying effect mechanisms at neighborhood level. We aim contribute evidence base for research. Methods Results created new data set census tract level by integrating 4 types potential...
Methods for estimating heterogeneous treatment effect in observational data have largely focused on continuous or binary outcomes, and been relatively less vetted with survival outcomes. Using flexible machine learning methods the counterfactual framework is a promising approach to address challenges due complex individual characteristics, which treatments need be tailored. To evaluate operating characteristics of recent estimation heterogeneity inform better practice, we carry out...
During untreated, chronic HIV-1 infection, plasma viral load (VL) is a relatively stable quantitative trait that has clinical and epidemiological implications. Immunogenetic research established various human genetic factors, especially leukocyte antigen (HLA) variants, as independent determinants of VL set-point.To identify clarify HLA alleles are associated with either transient or durable immune control we evaluated the relationships class I II among 563 seroprevalent Zambians (SPs) who...
Summary The timing of antiretroviral therapy (ART) initiation for HIV and tuberculosis (TB) co-infected patients needs to be considered carefully. CD4 cell count can used guide decision making about when initiate ART. Evidence from recent randomized trials observational studies generally supports early but does not provide information effects time on a continuous scale. In this article, we develop apply highly flexible structural proportional hazards model characterizing the effect treatment...
Abstract Evidence supporting the current World Health Organization recommendations of early antiretroviral therapy (ART) initiation for adolescents is inconclusive. We leverage a large observational data and compare, in terms mortality CD4 cell count, dynamic treatment rules human immunodeficiency virus-infected adolescents. Our approaches extend marginal structural model estimating outcome distributions under regimes, developed Robins et al. (2008), to allow causal comparisons both specific...
Crohn's disease [CD] recurrence following ileocolic resection [ICR] is common. We sought to identify blood-based biomarkers associated with CD recurrence.CD patients undergoing ICR were recruited across six centres. Serum samples obtained at post-operative colonoscopy. A multiplex immunoassay was used analyse 92 inflammation-related proteins [Olink Proteomics]. Bayesian analysis increasing Rutgeerts score. Identified in receiver operating characteristic [ROC] examine the ability [Rutgeerts...
In the absence of a randomized experiment, key assumption for drawing causal inference about treatment effects is ignorable assignment. Violations ignorability may lead to biased effect estimates. Sensitivity analysis helps gauge how conclusions will be altered in response potential magnitude departure from assumption. However, sensitivity approaches unmeasured confounding context multiple treatments and binary outcomes are scarce. We propose flexible Monte Carlo approach such settings....
Abstract Propensity score (PS) methods, including inverse probability of treatment weighting (IPTW) analysis, are increasingly applied to complex survey data in geriatric studies infer causal effects. However, the comparative effectiveness various PS estimation particularly novel machine learning algorithms, has not been thoroughly explored when involved. We conducted a comprehensive simulation study compare following six methods IPTW analysis: Logistic Regression, Covariate Balancing Score,...
Background Human leukocyte antigen (HLA) class I genes mediate cytotoxic T-lymphocyte responses and natural killer cell function. In a previous study, several HLA-B HLA-C alleles haplotypes were positively or negatively associated with the occurrence prognosis of glioblastoma multiforme (GBM). Methodology/Principal Findings As an extension Upper Midwest Health Study, we have performed HLA genotyping for 149 GBM patients healthy control subjects from non-metropolitan population consisting...
Polymorphisms in chemokine (C-C motif) receptors 2 and 5 genes (CCR2 CCR5) have been associated with HIV-1 infection disease progression. We investigated the impact of CCR2-CCR5 haplotypes on viral load (VL) heterosexual transmission an African cohort. Between 1995 2006, cohabiting Zambian couples discordant for (index seropositive exposed seronegative {HESN}) were monitored prospectively to determine role host genetic factors control transmission. Genotyping eight CCR2 CCR5 variants...
The 'Cash Transfer to Orphans and Vulnerable Children' (CT-OVC) in Kenya is a government-supported program intended provide regular predictable cash transfers (CT) poor households taking care of OVC. CT programs can be an effective means alleviating poverty facilitating the attainment adequate standard living for people's health well-being other international human rights. objective this analysis was compare household socioeconomic status, school enrolment, nutritional future outlook...