A5033286909- Inflammatory Bowel Disease
- Microscopic Colitis
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Mycobacterium research and diagnosis
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Viral gastroenteritis research and epidemiology
- Genetic factors in colorectal cancer
- Diverticular Disease and Complications
- Nosocomial Infections in ICU
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Diagnosis and treatment of tuberculosis
- Tuberculosis Research and Epidemiology
- Celiac Disease Research and Management
- Cytokine Signaling Pathways and Interactions
- Chronic Lymphocytic Leukemia Research
- Gastrointestinal motility and disorders
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Treatments and Studies
- IL-33, ST2, and ILC Pathways
Pontificia Universidad Católica de Chile
2015-2025
Sinai Hospital
2025
Lunenfeld-Tanenbaum Research Institute
2021-2025
University of Toronto
2020-2024
Mount Sinai Hospital
2019-2024
Sinai Health System
2021-2024
Weatherford College
2022
Abstract Background Primary sclerosing cholangitis associated with inflammatory bowel disease [IBD-PSC] carries significant morbidity compared to IBD without PSC. Alterations in microbial composition and bile acid [BA] profiles have been shown modulate chronic inflammation IBD, but data IBD-PSC are scarce. We aimed assess the differences gut microbiome as well BAs profile BA-related functions between IBD-only. Methods In total, 54 62 IBD-only subjects were enrolled from 2012 2021. Baseline...
Background. The incidence of liver cirrhosis is significantly high in Latin population. prevalence nonalcoholic fatty disease NAFLD likely partially responsible for these figures. Liver biopsy not a practical diagnostic option this scenario. validation noninvasive markers fibrosis important populations with NAFLD. Aim. To compare the value assessment systems to detect cohort patients biopsy-proven Material and methods. Patients were included. Noninvasive evaluations included calculations...
Crohn's disease [CD] recurrence following ileocolic resection [ICR] is common. We sought to identify blood-based biomarkers associated with CD recurrence.CD patients undergoing ICR were recruited across six centres. Serum samples obtained at post-operative colonoscopy. A multiplex immunoassay was used analyse 92 inflammation-related proteins [Olink Proteomics]. Bayesian analysis increasing Rutgeerts score. Identified in receiver operating characteristic [ROC] examine the ability [Rutgeerts...
Abstract Background Inflammatory bowel disease (IBD) is on the rise in South America, but this population remains underrepresented IBD genetic studies. Moreover, structure varies across American countries, highlighting need for studies that assess and its association with phenotypes. We conducted a study to examine correlation between Amerindian ancestry phenotypes within cohort. Additionally, we investigated previously identified risk variants Methods performed global analysis using...
Abstract Background Relatives of inflammatory bowel disease (IBD) patients have a higher risk developing the condition than general population. Approximately 12% IBD cases are familial. We aim to evaluate prevalence family history (FH-IBD) in Crohn’s (CD) and ulcerative colitis (UC) patients, identify clinical characteristics linked FH-IBD risk, develop polygenic score (PRS) for FH-IBD. Methods Patients were recruited from Chilean referral center between 2019 2024, yielding data 412...
Abstract Background Patients with inflammatory bowel diseases (IBD) may develop extraintestinal manifestations (EIM) that increase their morbidity. We investigated clinical and genetic factors associated EIM, analyzing an IBD cohort between 2019-2024. designed predictive models for EIM using machine learning techniques. Methods A total of 414 patients were recruited (314 UC 100 CD). The presence was assessed, differences the groups without analyzed Chi-square tests Mann-Whitney U tests. In a...
Abstract Background Intestinal surgery is a key treatment for Crohn’s disease (CD). Large cohort data on perioperative management are vital to improve postoperative outcomes. This study aimed assess and compare preoperative characteristics across three large prospective studies of CD patients following ileocolic resection (ICR). Methods The IMPACT consortium (International Multidisciplinary Research Collaboration Postoperative IBD) an intercontinental initiative focused inflammatory bowel...
Research in Inflammatory Bowel Disease (IBD) assessing the genetic structure and its association with IBD phenotypes is needed, especially IBD-underrepresented populations such as South American population. Aim. We examine correlation between Amerindian ancestry within a cohort investigate previously identified risk variants phenotypes. assessed ancestral (IBD = 291, Controls 51) to (AMR) variables. Additionally, we analyzed influence of known factors on disease outcomes. used Chi-square...
Abstract Background and Aims Multiple factors are suggested to place Crohn’s disease patients at risk of recurrence after ileocolic resection with conflicting associations. We aimed identify clinical predictors first [early] further [late] postoperative colonoscopy. Methods undergoing were prospectively recruited six North American centres. Clinical data collected endoscopic was defined as Rutgeerts score ≥i2. A multivariable model fitted analyse variables independently associated...
SUMMARY In a 1-year survey at university hospital we found that 20·6% (81/392) of patients with antibiotic associated diarrohea where positive for C. difficile . The most common PCR ribotypes were 012 (14·8%), 027 (12·3%), 046 (12·3%) and 014/020 (9·9). incidence rate was 2·6 cases infection every 1000 outpatients.
Abstract Background and Aims Microbial-derived bile acids can modulate host gene expression, their faecal abundance is decreased in active inflammatory bowel disease [IBD]. We analysed the impact of endoscopic inflammation on microbial genes involved acid biotransformation, interaction with transcriptome intestinal mucosa IBD patients. Methods Endoscopic mucosal biopsies were collected from non-inflamed inflamed terminal ileum, ascending sigmoid colon Prediction imputed metagenome functional...
A composite endpoint of histological and endoscopic remission is proposed to be the most complete measure mucosal healing in ulcerative colitis [UC]. We aim establish prognosis, transcriptional microbial features histo-endoscopic activity.A cross-sectional rectosigmoid colon sample collection from UC patients healthy controls [HC] was performed for histopathology host genome-wide RNA-sequencing. Histo-endoscopic activity were defined as Mayo subscore [MES] 0-1 with without activity,...
Chilean consensus of prevention, diagnosis and treatment ofClostridium difficile-associated diarrhea