A5022796764- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Medical Image Segmentation Techniques
- Fetal and Pediatric Neurological Disorders
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Medical Imaging and Analysis
- Neurobiology of Language and Bilingualism
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Brain Metastases and Treatment
- Immunotherapy and Immune Responses
- Anatomy and Medical Technology
- Cerebrospinal fluid and hydrocephalus
- Neural dynamics and brain function
- Spectroscopy Techniques in Biomedical and Chemical Research
- Ultrasound and Hyperthermia Applications
- Robotics and Sensor-Based Localization
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Brain Tumor Detection and Classification
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Neurological Surgery
2007-2024
Lemuel Shattuck Hospital
2023
University of Parma
2021
Oxford University Press (United Kingdom)
2020
Dana-Farber Brigham Cancer Center
2010-2017
Cincinnati Children's Hospital Medical Center
2017
Charleston Area Medical Center
2017
Children's National
2017
Stimulated Raman scattering microscopy provides a rapid, label-free means of detecting tumor infiltration brain tissue ex vivo and in vivo.
Numerous observations in patients with unilateral lesions of the medial temporal lobe (MTL) and prefrontal cortex indicate that memory processes are lateralized according to content. Left-sided interfere verbal processes, whereas right-sided visuospatial (non-verbal) processes. However, functional imaging studies have resulted contradictory data, some showing lateralization determined by stage processing (encoding versus retrieval) others suggesting is dependent on type material. Few...
Abstract Background With increasing research on system integration for image‐guided therapy (IGT), there has been a strong demand standardized communication among devices and software to share data such as target positions, images device status. Method We propose new, open, simple extensible network protocol IGT, named OpenIGTLink, transfer transform, image status messages. conducted performance tests use‐case evaluations in five clinical engineering scenarios. Results The was able position...
Brain tissue biopsies are required to histologically diagnose brain tumors, but current approaches limited by characterization at the time of surgery. Emerging technologies such as mass spectrometry imaging can enable a rapid direct analysis cancerous based on molecular composition. Here, we illustrate how gliomas be rapidly classified desorption electrospray ionization-mass (DESI-MS) imaging, multivariate statistical analysis, and machine learning. DESI-MS was carried out 36 human glioma...
The main goal of brain tumor surgery is to maximize resection while preserving function. However, existing imaging and surgical techniques do not offer the molecular information needed delineate boundaries. We have developed a system rapidly analyze classify tumors based on lipid acquired by desorption electrospray ionization mass spectrometry (DESI-MS). In this study, classifier was built discriminate gliomas meningiomas 36 glioma 19 meningioma samples. tested results were validated for...
Significance The diagnosis of tumors during surgery still relies principally on an approach developed over 150 y ago: frozen section microscopy. We show that a validated molecular marker—2-hydroxyglutarate generated from isocitrate dehydrogenase 1 mutant gliomas—can be rapidly detected using form ambient MS does not require sample preparation. use the Advanced Multimodality Image Guided Operating Suite at Brigham and Women’s Hospital to demonstrate desorption electrospray ionization could...
Volumetric change in glioblastoma multiforme (GBM) over time is a critical factor treatment decisions. Typically, the tumor volume computed on slice-by-slice basis using MRI scans obtained at regular intervals. (3D)Slicer – free platform for biomedical research provides an alternative to this manual segmentation process, which significantly faster and requires less user interaction. In study, 4 physicians segmented GBMs 10 patients, once competitive region-growing based GrowCut module of...
To assess the diagnostic accuracy and prognostic value of functional MRI (fMRI) in determining lateralization predicting postsurgical language memory outcomes.An 11-member panel evaluated rated available evidence according to 2004 American Academy Neurology process. At least 2 panelists reviewed full text 172 articles selected 37 for data extraction. Case reports, reports with <15 cases, meta-analyses, editorials were excluded.The use fMRI may be considered an option lateralizing functions...
Gain-of-function mutations in isocitrate dehydrogenase (IDH) human cancers result the production of d-2-hydroxyglutarate (d-2HG), an oncometabolite that promotes tumorigenesis through epigenetic alterations. The cancer cell-intrinsic effects d-2HG are well understood, but its tumor cell-nonautonomous roles remain poorly explored. We compared with enantiomer, l-2HG, and found tumor-derived was taken up by CD8+ T cells altered their metabolism antitumor functions acute reversible fashion....
White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white pathways in vivo human brains. However, like other analyses complex data, there is considerable variability protocols and techniques. This can result different reconstructions same intended pathways, which directly affects results, quantification, interpretation. In this study, we aim evaluate quantify that arises from for segmentation. Through an open call users...
Alzheimer's disease is the most common cause of dementia in older adults. Although cognitive deficits and pathologic hallmarks have been well characterized, few functional imaging studies examined competency specific brain regions their relationship to behavioural memory disease. We used MRI (fMRI) examine seven early stage patients healthy age-matched neurologically normal control subjects during intentional encoding scenes. Subjects viewed blocks novel scenes, repeated scenes or baseline....
We present a new algorithm to register 3-D preoperative magnetic resonance (MR) images intraoperative MR of the brain which have undergone shift. This relies on robust estimation deformation from sparse noisy set measured displacements. propose framework compute displacement field in an iterative process, allowing solution gradually move approximation formulation (minimizing sum regularization term and data error term) interpolation (least square minimization term). An outlier rejection step...
Summary: Purpose: To determine the utility of functional magnetic resonance imaging (fMRI) in preoperative lateralization memory function patients with medial temporal lobe epilepsy (MTLE). Methods: Nine MTLE underwent standard assessment including video‐EEG and intracarotid amytal testing (IAT). fMRI was performed while subjects encoded four types stimuli (patterns, faces, scenes, words). Activation maps were created for each subject representing areas more active novel than repeated...
Presurgical language mapping for patients with lesions close to areas is critical neurosurgical decision‐making preservation of function. As a clinical noninvasive imaging technique, functional MRI (fMRI) used identify by measuring blood‐oxygen‐level dependent (BOLD) signal change while perform carefully timed vs. control tasks. This task‐based fMRI critically depends on task performance, excluding many who have difficulty performing tasks due neurologic deficits. On the basis recent...
Diffusion tensor imaging (DTI) tractography reconstruction of white matter pathways can help guide brain tumor resection. However, DTI tracts are complex mathematical objects and the validity tractography-derived information in clinical settings has yet to be fully established. To address this issue, we initiated Challenge, an international working group clinicians scientists whose goal was provide standardized evaluation methods for neurosurgery. The purpose empirical study evaluate...
Abstract The TCR is comprised of two variable chains that confer specificity, called alpha:beta or gamma:delta, physically associated with five different molecules comprise the complex known as CD3. Antibodies to this are very useful, they react all T lymphocytes. A rat mAb mouse CD3 has been prepared. It reacts 100% cells in strains tested but no other cell type. binds epsilon chain. This antibody activates cloned lines and normal cells, provided suitable accessory signals present. detects...
<h3>Objective</h3> To quantify size and localization differences between tumors presenting with seizures vs nonseizure neurological symptoms. <h3>Design</h3> Retrospective imaging survey. We performed magnetic resonance imaging–based morphometric analysis nonparametric mapping in patients brain tumors. <h3>Setting</h3> University-affiliated teaching hospital. <h3>Patients or Other Participants</h3> One hundred twenty-four newly diagnosed supratentorial glial <h3>Main Outcome Measures</h3>...
Abstract The goal of brain tumor surgery is to maximize removal without injuring critical structures. Achieving this challenging as it can be difficult distinguish from nontumor tissue. While standard histopathology provides information that could assist delineation, cannot performed iteratively during freezing, sectioning, and staining the tissue require too much time. Stimulated Raman scattering (SRS) microscopy a powerful label-free chemical imaging technology enables rapid mapping lipids...