A5053223648- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Scoliosis diagnosis and treatment
- Cervical and Thoracic Myelopathy
- Management of metastatic bone disease
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Medical Imaging and Analysis
- Neurofibromatosis and Schwannoma Cases
- Cannabis and Cannabinoid Research
- Spinal Hematomas and Complications
- Bone Tumor Diagnosis and Treatments
- Pelvic and Acetabular Injuries
- Traumatic Brain Injury and Neurovascular Disturbances
- Head and Neck Surgical Oncology
- Musculoskeletal pain and rehabilitation
- Cancer Cells and Metastasis
- Radiopharmaceutical Chemistry and Applications
- Blood transfusion and management
- Diet, Metabolism, and Disease
- Cardiac, Anesthesia and Surgical Outcomes
- Photodynamic Therapy Research Studies
- Spinal Dysraphism and Malformations
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
NYU Langone Health
2022-2025
University of California, San Francisco
2014-2024
Neurological Surgery
2015-2024
New York University
2021-2023
California Pacific Medical Center
2010-2023
University of San Francisco
2014-2021
Employment Agency
2020
International Breast Cancer Study Group
2020
Oxford University Press (United Kingdom)
2018-2020
Johnson & Johnson (United States)
2020
Stimulated Raman scattering microscopy provides a rapid, label-free means of detecting tumor infiltration brain tissue ex vivo and in vivo.
Awake craniotomy is currently a useful surgical approach to help identify and preserve functional areas during cortical subcortical tumor resections. Methodologies have evolved over time maximize patient safety minimize morbidity using this technique. The goal of study analyze single surgeon's experience the evolving methodology awake language sensorimotor mapping for glioma surgery.The authors retrospectively studied patients undergoing brain surgery between 1986 2014. Operations initial...
The extent of resection (EOR) is a known prognostic factor in patients with glioblastoma. However, gross-total (GTR) not always achieved. Understanding the factors that prevent GTR helpful surgical planning and when counseling patients. goal this study was to identify demographic, tumor-related, technical influence EOR define relationship between surgeon's impression radiographically determined EOR.The authors performed retrospective review electronic medical records all who underwent...
Resection is an appealing therapy for brain arteriovenous malformations (AVMs) because of its high cure rate, low complication and immediacy, has become the first-line many AVMs. To clarify safety, efficacy, outcomes associated with AVM resection in aftermath A Randomized Trial Unruptured Brain AVMs (ARUBA), authors reviewed their experience low-grade AVMs-the most favorable surgery ones likely to have been selected treatment outside ARUBA's randomization process.A prospective registry was...
The cannabinoid 1 (CB(1)) and 2 (CB(2)) receptor agonist Delta(9)-tetrahydrocannabinol (THC) has been shown to be a broad-range inhibitor of cancer in culture vivo, is currently being used clinical trial for the treatment glioblastoma. It suggested that other plant-derived cannabinoids, which do not interact efficiently with CB(1) CB(2) receptors, can modulate actions Delta(9)-THC. There are conflicting reports, however, as what extent cannabinoids Delta(9)-THC activity, most importantly, it...
OBJECT There is evidence that 5-aminolevulinic acid (ALA) facilitates greater extent of resection and improves 6-month progression-free survival in patients with high-grade gliomas. But there remains a paucity studies have examined whether the intensity ALA fluorescence correlates tumor cellularity. Therefore, Phase II clinical trial was undertaken to examine correlation degree METHODS A single-center, prospective, single-arm, open-label fluorescence-guided gliomas (Grade III IV) held over...
OBJECTIVE Cervical curvature is an important factor when deciding between laminoplasty and laminectomy with posterior spinal fusion (LPSF) for cervical spondylotic myelopathy (CSM). This study compares outcomes following LPSF in patients matched postoperative lordosis. METHODS Adults undergoing or CSM from 2011 to 2014 were identified. Matched cohorts obtained by excluding Cobb angles outside the range of patients. Clinical radiographic results compared. A subgroup analysis without...
A reported risk factor for adjacent-segment disease is injury to the superior facet joint from pedicle screw placement. Given that not typically visualized during percutaneous insertion, there a concern increased violation (FV) in minimally invasive fusion procedures. The purpose of this study was analyze and compare incidence FV among patients undergoing transforaminal lumbar interbody (MITLIF) open (TLIF). impact O-arm navigation compared with traditional fluoroscopy on MITLIF also...
OBJECT Spinal metastases most commonly affect the vertebral bodies of spinal column, and cord compression is an indication for surgery. Commonly, open posterior approach employed to perform a transpedicular costotransversectomy or lateral extracavitary corpectomy. Because short life expectancies in patients with metastatic disease, decreasing morbidity surgical treatment recovery time critical. One potential utilizing minimally invasive surgery (MIS). Although significant advances have been...
Object Whereas standard anterior approaches for thoracolumbar corpectomies have commonly been used, the transpedicular technique is increasingly used to perform from a posterior approach. The authors conducted study analyze whether there was difference in outcomes by comparing corpectomies. Methods senior author performed 80 patients between 2004 and 2008. reviewed medical records follow-up data, consisting of clinic visits, radiographs, or telephone interviews. Neurological outcome,...
Smoking is one of the leading causes preventable morbidity and death in U.S. has been associated with perioperative complications. In this study, authors examined effects smoking on outcomes pseudarthrosis rates following anterior cervical corpectomy.All adult patients from 2006 to 2011 who underwent corpectomy were identified. Patients categorized into 3 groups: never smoked (nonsmokers), quit for at least 1 year (quitters), continue smoke (current smokers). Demographic, medical, surgical...
Though challenging, maximal safe resection of insular gliomas enhances overall and progression-free survival deters malignant transformation. Previously published reports have shown that surgery can be performed with low morbidity. The authors previously described a Berger-Sanai zone classification system for gliomas. Using subsequent dataset, they undertook this study to validate predictability extent (EOR) in patients gliomas.The population included adults who had undergone WHO Grade II,...
Minimally invasive (MI) transforaminal lumbar interbody fusion (TLIF) has been demonstrated in previous studies to offer improvement pain and function comparable those provided by the open surgical approach. However, comparative obese population are scarce, it is possible that patients may respond differently these two approaches. In this study, authors compared clinical benefit of MI TLIF patients.The conducted a retrospective cohort study based on review electronic medical records at...
In the treatment of cervical spondylotic myelopathy (CSM), anterior corpectomy and fusion (ACCF) discectomy (ACDF) are effective decompressive techniques. It remains to be determined whether ACCF ACDF offer equivalent outcomes for multilevel CSM. this study, authors compared perioperative, radiographic, clinical between 2-level 3-level ACDF.Between 2006 2012, all patients at authors' hospital who underwent or performed by 1 2 surgeons were identified. Primary interest sagittal Cobb angle,...
OBJECTIVE Functional mapping using direct cortical stimulation is the gold standard for prevention of postoperative morbidity during resective surgery in dominant-hemisphere perisylvian regions. Its role necessitated by significant interindividual variability that has been observed essential language sites. The aim this study was to determine statistical probability distribution eliciting aphasic errors any given stereotactically based position a patient cohort and quantify at each site....
Object The use of intraoperative neurophysiological monitoring (IONM) in surgical decompression surgery for myelopathy may assist the surgeon taking corrective measures to reduce or prevent permanent neurological deficits. We evaluated efficacy IONM cervical and cervicothoracic spondylotic (CSM) cases. Methods authors retrospectively reviewed 140 cases involving patients who underwent CSM utilizing during 2011 at University California, San Francisco. Data on preoperative clinical variables,...
OBJECTIVE Proximal junctional kyphosis (PJK) is a well-recognized, yet incompletely defined, complication of adult spinal deformity surgery. There no standardized definition for PJK, but most studies describe PJK as an increase in the proximal angle (PJA) greater than 10°-20°. Ligament augmentation novel strategy reduction that provides strength to upper instrumented vertebra (UIV) and adjacent segments while also reducing stress at those levels. METHODS In this study, ligament was used...
Novel methods in predicting survival patients with spinal metastases may help guide clinical decision-making and stratify treatments regarding surgery vs palliative care.To evaluate whether the frailty/sarcopenia paradigm is predictive of morbidity undergoing for metastasis.A total 271 from 4 tertiary care centers who had undergone metastasis were identified. Frailty/sarcopenia was defined by psoas muscle size. Survival hazard ratios calculated using multivariate analysis, variables...
BACKGROUND AND OBJECTIVES: Intraoperative red blood cell (RBC) salvage is frequently used in contemporary spine surgery, despite clinical concern its efficacy as a surrogate for blood-banked allogeneic packed RBCs (pRBCs). During salvaged (sRBCs) are exposed to injurious high-heat electrocautery, prolonged stasis, and abrasive pharmaceuticals, potentially making sRBCs poor substitute. We therefore sought scientifically objectively define the quality of context complex surgery. METHODS: This...
Mesh cages have commonly been used for reconstruction after corpectomy. Recently, expandable become a popular alternative. Regardless of cage type, subsidence is concern following placement.To assess whether rates differ between static and cages, identify independent risk factors extent when present.A consecutive population patients who underwent corpectomy 2006 2009 was identified. Subsidence assessed via x-ray at 1-month 1-year follow-ups. In addition to demographic, medical, cage-related...
Object Minimally invasive (MI) transforaminal lumbar interbody fusion (TLIF) has proven to be effective in the treatment of spondylolisthesis and degenerative disc disease (DDD). Compared with traditional open TLIF, MI procedure been associated less blood loss, postoperative pain, a shorter hospital stay. However, it is uncertain whether advantages an TLIF also apply specifically obese patients. This study was dedicated evaluating patients reap perioperative benefits similar those seen...