Khoi D. Than

ORCID: 0000-0003-2026-7004
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About
Contact & Profiles
Research Areas
  • Spine and Intervertebral Disc Pathology
  • Spinal Fractures and Fixation Techniques
  • Scoliosis diagnosis and treatment
  • Cervical and Thoracic Myelopathy
  • Pelvic and Acetabular Injuries
  • Medical Imaging and Analysis
  • Management of metastatic bone disease
  • Spinal Dysraphism and Malformations
  • Musculoskeletal pain and rehabilitation
  • Anesthesia and Pain Management
  • Spinal Hematomas and Complications
  • Intraoperative Neuromonitoring and Anesthetic Effects
  • Cerebrospinal fluid and hydrocephalus
  • Head and Neck Surgical Oncology
  • Intracranial Aneurysms: Treatment and Complications
  • Neurofibromatosis and Schwannoma Cases
  • Orthopaedic implants and arthroplasty
  • Infectious Diseases and Tuberculosis
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Shoulder Injury and Treatment
  • Sarcoma Diagnosis and Treatment
  • Meningioma and schwannoma management
  • Cancer Cells and Metastasis
  • Peripheral Nerve Disorders
  • Cardiac, Anesthesia and Surgical Outcomes

Duke Medical Center
2020-2025

Duke University Hospital
2020-2025

Duke University
2020-2025

Neurological Surgery
2014-2024

University of California, San Francisco
2014-2023

Oregon Health & Science University
2015-2021

Expert System (Italy)
2020-2021

University Hospitals of Cleveland
2019

University of Pittsburgh
2019

University of Miami
2019

OBJECTIVE Cervical curvature is an important factor when deciding between laminoplasty and laminectomy with posterior spinal fusion (LPSF) for cervical spondylotic myelopathy (CSM). This study compares outcomes following LPSF in patients matched postoperative lordosis. METHODS Adults undergoing or CSM from 2011 to 2014 were identified. Matched cohorts obtained by excluding Cobb angles outside the range of patients. Clinical radiographic results compared. A subgroup analysis without...

10.3171/2017.4.spine16831 article EN Journal of Neurosurgery Spine 2017-09-01

Minimally invasive surgery (MIS) can be used as an alternative or adjunct to traditional open techniques for the treatment of patients with adult spinal deformity. Recent advances in MIS techniques, including advanced anterior approaches, have increased range candidates deformity surgery. The minimally (MISDEF2) algorithm was created provide updated framework decision-making when considering correction

10.3171/2019.7.spine181104 article EN Journal of Neurosurgery Spine 2019-10-26

Study Design: A multicenter, retrospective review of C5 palsy after cervical spine surgery. Objective: Postoperative is a known complication decompressive spinal The goal this study was to the incidence, patient characteristics, and outcome in patients undergoing Methods: We conducted 13 946 across 21 centers who received surgery (levels C2 C7) between January 1, 2005, December 31, 2011, inclusive. P values were calculated using 2-sample t test for continuous variables χ 2 tests or Fisher...

10.1177/2192568216688189 article EN cc-by-nc-nd Global Spine Journal 2017-04-01

Unintended durotomy is a relatively common complication in spine surgery, with reported incidence up to 14%. Traditional management has been mandatory bed rest for at least 48 h following repair, or without placement of drain. With the muscle-splitting approach and decreased potential (dead) space created during minimally invasive spinal surgery (MISS), there less likelihood symptoms such as headaches cerebrospinal fluid fistulas. We reviewed cases 5 patients undergoing lumbar MISS...

10.1055/s-0028-1082313 article EN min - Minimally Invasive Neurosurgery 2008-10-01

Incisional cerebrospinal fluid (CSF) leak remains a significant cause of morbidity, particularly after posterior fossa surgery, with ranges between 4 and 17% in most series. We aimed to determine whether the use new polyethylene glycol (PEG) dural sealant product (DuraSeal; Confluent Surgical, Waltham, MA) is effective at preventing incisional CSF surgery.One hundred cases surgery PEG applied time closure were prospectively observed from May 2005 April 2006. All patients underwent craniotomy...

10.1227/01.neu.0000335034.08274.d2 article EN PubMed 2008-07-01

The middle cranial fossa (MCF) approach is a microsurgical technique described as primary option in the treatment of small, intracanalicular schwannomas involving eighth nerve. Excellent rates complete tumor resection, hearing preservation, preservation facial nerve function, and low complication have been reproduced using this technique. However, durability attained various options has not adequately assessed. purpose study was to evaluate long-term patients with vestibular schwannoma (VS)...

10.3171/2013.1.jns1297 article EN Journal of neurosurgery 2013-02-15

OBJECT Spinal tumor resection has historically been performed via open approaches, although minimally invasive approaches have recently found to be effective in small cohort series. The authors compare surgical characteristics and clinical outcomes of surgery patients undergoing mini-open for intradural-extramedullary resection. METHODS retrospectively reviewed 65 consecutive resections at their institution from 2007 2014. Patients with cervical tumors or pathology demonstrating neurofibroma...

10.3171/2015.5.focus15187 article EN Neurosurgical FOCUS 2015-08-01

OBJECTIVE Minimally invasive surgery (MIS) techniques are increasingly used to treat adult spinal deformity. However, standard minimally deformity have a more limited ability restore sagittal balance and match the pelvic incidence–lumbar lordosis (PI-LL) than traditional open surgery. This study sought compare “best” versus “worst” outcomes of MIS identify variables that may predispose patients postoperative success. METHODS A retrospective review cases was performed parameters in 20% who...

10.3171/2015.12.spine15999 article EN Journal of Neurosurgery Spine 2016-03-04

Study Design. Expert opinion—modified Delphi study. Objective. We used a modified approach to obtain consensus among leading spinal deformity surgeons and their neuroanesthesiology teams regarding optimal practices for obtaining reliable motor evoked potential (MEP) signals. Summary of Background Data. Intraoperative neurophysiological monitoring transcranial MEPs provides the best method assessing cord integrity during complex surgeries. are affected by pharmacological physiological...

10.1097/brs.0000000000003433 article EN Spine 2020-02-20

OBJECTIVE The objective was to determine the degree of regional decompensation pelvic tilt (PT) normalization after complex adult spinal deformity (ASD) surgery. METHODS Operative ASD patients with 1 year PT measurements were included. Patients normalized at baseline excluded. Predicted compared actual PT, tested for change from baseline, and then against age-adjusted, Scoliosis Research Society–Schwab, global alignment proportion (GAP) scores. Lower-extremity (LE) parameters included...

10.3171/2023.11.spine23766 article EN Journal of Neurosurgery Spine 2024-01-13

OBJECTIVE The goal of this study was to compare the impact using a lower thoracic (LT) versus upper lumbar (UL) level as instrumented vertebra (UIV) on clinical and radiographic outcomes following minimally invasive surgery for adult spinal deformity. METHODS A multicenter retrospective design used. Inclusion criteria were age ≥ 18 years, one following: coronal Cobb angle > 20°, sagittal vertical axis 50 mm, pelvic tilt incidence–lumbar lordosis mismatch 10°. Patients treated with...

10.3171/2024.8.spine231335 article EN Journal of Neurosurgery Spine 2025-01-01

INTRODUCTION: LLIF patients have shown a high success rate of fusion, but limited data exist on the influence implant design clinical and radiographic outcomes from prospective, comparative studies. METHODS: Prospective, multi-center study, randomized to receive allograft cancellous chips with autologous bone marrow aspirate or cellular matrix. All subjects had 6-month CT imaging reviewed for fusion by three spine surgeons, condition subsidence an independent core lab. RESULTS: 117 were...

10.1227/neu.0000000000003360_1062 article EN Neurosurgery 2025-03-14
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