Zhe Guan

ORCID: 0009-0006-1422-6408
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About
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Research Areas
  • Spinal Fractures and Fixation Techniques
  • Spine and Intervertebral Disc Pathology
  • Cervical and Thoracic Myelopathy
  • Photosynthetic Processes and Mechanisms
  • Pelvic and Acetabular Injuries
  • Polyomavirus and related diseases
  • Plant Gene Expression Analysis
  • Lanthanide and Transition Metal Complexes
  • MicroRNA in disease regulation
  • DNA and Nucleic Acid Chemistry
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Plant Stress Responses and Tolerance
  • Drug-Induced Adverse Reactions
  • Reproductive System and Pregnancy
  • Circular RNAs in diseases
  • Elder Abuse and Neglect
  • Pregnancy-related medical research
  • Cerebrospinal fluid and hydrocephalus
  • Heterotopic Ossification and Related Conditions
  • Single-cell and spatial transcriptomics
  • Hematopoietic Stem Cell Transplantation
  • Breastfeeding Practices and Influences
  • Insect-Plant Interactions and Control
  • Light effects on plants
  • Dental Radiography and Imaging

Soochow University
2025

Second Affiliated Hospital of Soochow University
2025

University of Connecticut
2024

China Southern Power Grid (China)
2024

Shanxi Medical University
2009-2023

Weatherford College
2023

Xiangya Hospital Central South University
2023

Central South University
2023

East China Normal University
2020

Shanxi Provincial Cancer Hospital
2014-2019

Autonomic dysreflexia (AD), a potentially dangerous complication of high-level spinal cord injury (SCI) characterized by exaggerated activation autonomic (sympathetic) reflexes, can cause pulmonary embolism, stroke, and, in severe cases, death. People with SCI also are immune compromised, rendering them more susceptible to infectious morbidity and mortality. The mechanisms underlying postinjury suppression not known. Data presented herein indicate that AD causes suppression. Using <i>in...

10.1523/jneurosci.1974-13.2013 article EN Journal of Neuroscience 2013-08-07

Nanobodies consist of a single domain variable fragment camelid heavy-chain antibody. have potential applications in biomedical fields because their simple production procedures and low cost. Occasionally, nanobody clones interest exhibit affinities for target antigens, which, together with short half-life limit bioanalytical or therapeutic applications. Here, we developed novel platform named fenobody, which against H5N1 virus is displayed on the surface ferritin form 24mer. We constructed...

10.1021/acs.analchem.7b05217 article EN Analytical Chemistry 2018-04-04

Mesh cages have commonly been used for reconstruction after corpectomy. Recently, expandable become a popular alternative. Regardless of cage type, subsidence is concern following placement.To assess whether rates differ between static and cages, identify independent risk factors extent when present.A consecutive population patients who underwent corpectomy 2006 2009 was identified. Subsidence assessed via x-ray at 1-month 1-year follow-ups. In addition to demographic, medical, cage-related...

10.1227/neu.0b013e318282a558 article EN Neurosurgery 2012-12-18

Spinal muscular atrophy (SMA) is a severe neurodegenerative disorder caused by deficiency of survival motor neuron (SMN). While significant progress has been made in SMA therapy rescuing SMN expression, limited knowledge about downstream genes hindered the development alternative therapies. Here, we conducted whole-transcriptome sequencing spinal cord, heart, and liver tissues mouse model at early postnatal ages to explore critical coding non-coding RNAs (ncRNAs). A large number...

10.1016/j.omtn.2025.102490 article EN cc-by Molecular Therapy — Nucleic Acids 2025-02-20

10.47297/taposatwsp2633-456912.20250602 article EN Theory and Practice of Science and Technology 2025-01-01

Endothelial cells (ECs) and bone marrow stromal (BMSCs) play crucial roles in supporting hematopoiesis hematopoietic regeneration. However, whether ECs are a source of BMSCs remains unclear. Here, we evaluate the contribution endothelial-to-mesenchymal transition to BMSC generation postnatal mice. Single-cell RNA sequencing identifies expressing markers Prrx1 Lepr; however, this could not be validated using Prrx1-Cre Lepr-Cre transgenic Additionally, only minority marked by EC lineage...

10.1038/s41467-023-44312-w article EN cc-by Nature Communications 2023-12-20

Approximately 20%-30% of patients with anti-glomerular basement membrane disease present coexisting anti-myeloperoxidase (MPO) autoantibodies. We previously showed the recognition a linear fragment MPO heavy chain N-terminus ((1)H, MPO279-409) in plasma from most double-positive patients. Herein, we investigated frequency autoantibodies against overlapping (1)H-derived peptides disease.We synthesized 13 ((1)H-1 to (1)H-13) covering MPO279-409. retrospectively collected samples 67 1996 2012,...

10.2215/cjn.05270515 article EN Clinical Journal of the American Society of Nephrology 2016-01-27

Pale yellowing of leaf variegation is observed in the mutant Arabidopsis lines Calcineurin B-Like-Interacting Protein Kinase14 (CIPK14) overexpression (oeCIPK14) and double-knockout WHIRLY1/WHIRLY3 (why1/3). Further, relative distribution WHIRLY1 (WHY1) protein between plastids nucleus affected by phosphorylation WHY1 CIPK14. To elucidate coregulation CIPK14 WHIRLY1/WHIRLY3-mediated pale leaves, a differential proteomic analysis was conducted oeCIPK14 variegated (oeCIPK14-var) line, why1/3...

10.3390/ijms19082231 article EN International Journal of Molecular Sciences 2018-07-31

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; The introduction of intracranial air during deep brain stimulation (DBS) surgery is believed to negatively impact targeting accuracy and clinical outcomes. &lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; To quantify the relationship between (ICA) volumes, accuracy, outcomes in patients undergoing subthalamic nucleus (STN) DBS for Parkinson's disease. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; ICA 73 consecutive STN cases (146 leads) was...

10.1159/000452843 article EN Stereotactic and Functional Neurosurgery 2017-01-01

Background Stent-assisted coiling is commonly used to treat wide-necked and fusiform cerebral aneurysms. We evaluated our institutional experience with stent-assisted of aneurysms elucidate potential risk factors for recurrence. Methods A retrospective analysis patients undergoing from 2005 2012 resulted in 122 Demographic, peri-procedural, medical comorbidity, follow-up data were collected. Primary outcomes interest procedural safety, efficacy, aneurysm Univariate multivariate logistic...

10.1136/neurintsurg-2016-012704 article EN Journal of NeuroInterventional Surgery 2016-10-03

Retrospective case series.To compare perioperative end points and outcomes of single-level versus multilevel corpectomy performed using a modified costotransversectomy approach.Single-level via posterolateral approach has been shown to be an effective alternative the traditional anterior thoracotomy approach. However, there is paucity studies that have examined thoracic approach.Using electronic medical records, we identified consecutive population adult patients who underwent in region...

10.1097/brs.0b013e318273ab87 article EN Spine 2012-09-15

Abstract As the number of clinical trials conducted in China increases, understanding Chinese attitudes toward research is critical for designing effective and ethical studies. Two survey studies were 2012 2013 to compare patient factors affecting participation United States urban rural China. We surveyed 525 patients (186 US, 186 urban, 153 China) 690 (412 206 72 China). US more likely have no concerns regarding than patients. Most common safety, privacy confidentiality, time required....

10.1111/cts.12254 article EN other-oa Clinical and Translational Science 2015-01-15

Soybean aphid (Aphis glycines Matsumura) is one of the major limiting factors in soybean production. The mechanism resistance remains enigmatic as little information available about different mechanisms antibiosis and antixenosis. Here, we used genome-wide gene expression profiling susceptible, antibiotic, antixenotic genotypes to investigate underlying aphid–plant interaction mechanisms. high correlation between infested non-infested indicated that response was controlled by a small subset...

10.3390/ijms21155191 article EN International Journal of Molecular Sciences 2020-07-22

Leaf variegation pale yellowing is observed in the Calcineurin B-Like-Interacting Protein Kinase14 (CIPK14) overexpression line (oeCIPK14) and double knockout WHIRLY1/WHIRLY3 (why1/3) lines of Arabidopsis, distribution WHIRLY1 (WHY1) protein between plastids nucleus are affected by phosphorylation WHY1 CIPK14. To elucidate coregulation CIPK14 mediated leaf yellowing, a differential proteomic analysis conducted oeCIPK14 variegated (oeCIPK14-var) line, why1/3 (why1/3-var) wild type (WT). More...

10.20944/preprints201807.0111.v1 preprint EN 2018-07-06

Abstract A motorcyclist sustained multiple‐system trauma, including a left buttock hematoma requiring decompression and evacuation. Presentation for severe hip pain lower extremity weakness was delayed. Imaging revealed myositis ossificans traumatica compressing the sciatic nerve in buttock. The patient underwent with resection of heterotopic calcification, resulting improvement function. This case illustrates contrast differential diagnosis peripheral injury immediately posttrauma that...

10.1016/j.pmrj.2015.10.011 article EN PM&R 2015-11-05

Abstract Background Circular RNAs (circRNAs) have been confirmed to be involved in cancer pathogenesis. However, the underlying mechanism of circRNA endothelin converting enzyme 1 (circECE1) osteosarcoma (OS) development is still not understood. Methods The expression levels circECE1, microRNA-588 (miR-588) and RAB3D, member RAS oncogene family (RAB3D) were gauged by quantitative real-time polymerase chain reaction (qRT-PCR) western blot. OS cell proliferation was assessed counting kit-8...

10.1186/s13018-023-04045-4 article EN cc-by Journal of Orthopaedic Surgery and Research 2023-08-09

Abstract Introduction Women below the poverty threshold have lower representation and retention in breastfeeding studies. Methods A secondary analysis of a longitudinal randomized controlled self-management for breast nipple pain during study. Participants completed online surveys at discharge, weeks 1, 2, 3, 6, 9, 12, 18, 24, with face-to-face interviews 6 24 weeks. Text messages were sent to participants when modules due. Retention was assessed R descriptive statistics, Mann-Whitney,...

10.1101/2024.03.15.24304355 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2024-03-16

Abstract Purpose: To assess the effectiveness of educational HIV/AIDS prevention programs in two medical universities Shenyang, China. Methods: Changes knowledge and attitudes were evaluated following an intervention program involving 2,418 graduate students (n=1,319 group, n=1,099 control group), which was delivered by a final team 32 student peers who had been trained to be trainers for current study. Results: Following training, 72.6% learned that mosquito bites cannot transmit HIV....

10.2202/1948-4682.1147 article EN World Medical & Health Policy 2011-06-01
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