A5061175654- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Traumatic Brain Injury Research
- Posttraumatic Stress Disorder Research
- Influenza Virus Research Studies
- Herpesvirus Infections and Treatments
- Adrenal Hormones and Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Dermatology and Skin Diseases
- Viral gastroenteritis research and epidemiology
- Wound Healing and Treatments
- Immune cells in cancer
- Sleep and Wakefulness Research
- T-cell and B-cell Immunology
- Health, psychology, and well-being
- Psychosomatic Disorders and Their Treatments
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Hormonal Regulation and Hypertension
- interferon and immune responses
- Resilience and Mental Health
Institute for Behavioral Medicine
2016-2025
The Ohio State University
2016-2025
The Ohio State University Wexner Medical Center
2016-2025
Auckland City Hospital
2025
Emory University
2021-2023
Park Terrace Care Center
2023
McLean Hospital
2021-2022
University of Nevada, Las Vegas
2022
Temple University
2022
Provision Healthcare
2022
The underlying changes in biological processes that are associated with reported mental and physical health response to meditation have not been systematically explored. We performed a randomized, controlled study on the effects brain immune function of well-known widely used 8-week clinical training program mindfulness applied work environment healthy employees.We measured electrical activity before immediately after, then 4 months after an meditation. Twenty-five subjects were tested...
To determine whether a chronic stressor (caregiving for spouse with progressive dementia) is associated an impaired immune response to influenza virus vaccination, we compared 32 caregivers' vaccine responses those of sex-, age-, and socioeconomically matched control subjects. Caregivers showed poorer antibody following vaccination relative subjects as assessed by two independent methods, ELISA hemagglutination inhibition. also had lower levels in vitro virus-specific-induced interleukin 2...
Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role vivo was examined mice which the gene encoding MIP-1 had been disrupted. Homozygous mutant (-/-) were resistant to Coxsackievirus-induced myocarditis seen infected wild-type (+/+) mice. Influenza virus-infected -/- reduced pneumonitis delayed clearance of virus compared with +/+ The no overt hematopoietic abnormalities. These results...
Abstract Background Activation of the peripheral innate immune system stimulates secretion CNS cytokines that modulate behavioral symptoms sickness. Excessive production by microglia, however, may cause long-lasting and cognitive complications. The purpose this study was to determine if minocycline, an anti-inflammatory agent purported microglial inhibitor, attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, anhedonia. Methods In first set experiments effect...
Psychosocial stress is associated with altered immune function and development of psychological disorders including anxiety depression. Here we show that repeated social defeat in mice increased c-Fos staining brain regions fear threat appraisal promoted anxiety-like behavior a β-adrenergic receptor-dependent manner. Repeated also significantly the number CD11b + /CD45 high /Ly6C macrophages trafficked to brain. In addition, several inflammatory markers were on surface microglia (CD14, CD86,...
Significance Chronic exposure to adverse social environments is associated with increased risk of disease, and stress-related increases in the expression proinflammatory genes appear contribute these effects. The present study identifies a biological mechanism such effects ability sympathetic nervous system up-regulate bone marrow production immature, monocytes. These are mediated by β-adrenergic receptors myelopoietic growth factor GM-CSF, suggest new targets for interventions protect...
Social stress is associated with altered immunity and higher incidence of anxiety-related disorders. Repeated social defeat (RSD) a murine stressor that primes peripheral myeloid cells, activates microglia, induces anxiety-like behavior. Here we show RSD-induced behavior corresponded an exposure-dependent increase in circulating monocytes (CD11b(+)/SSC(lo)/Ly6C(hi)) brain macrophages (CD11b(+)/SSC(lo)/CD45(hi)). Moreover, region-dependent cytokine chemokine responses involved cell...
Altered inflammatory cytokine profiles are often observed in individuals suffering from major depression. Recent clinical work reports on elevated IL-6 and decreased IL-10 Elevated has served as a consistent biomarker of depression is proposed to influence depressive behavior through its ability counterbalance pro-inflammatory expression. Clinical animal studies suggest role for modifying behavior. Murine restraint stress (RST) regularly employed the study behavioral biological symptoms...
Interleukin-1β (IL-1β) is an inflammatory cytokine that plays a prominent role in stress-induced behavioral changes. In model of repeated social defeat (RSD), elevated IL-1β expression the brain was associated with recruitment primed macrophages were necessary for development anxiety-like behavior. Moreover, microglia activation and behavior RSD did not occur IL-1 receptor type-1 knock-out (IL-1R1 KO ) mice. Therefore, objective this study to examine signaling RSD-induced macrophage...
Repeated social defeat (RSD) is a murine stressor that recapitulates key physiological, immunological, and behavioral alterations observed in humans exposed to chronic psychosocial stress. Psychosocial stress promotes prolonged adaptations are associated with neuroinflammatory signaling impaired neuroplasticity. Here, we show RSD promoted hippocampal activation was characterized by proinflammatory gene expression microglia monocyte trafficking particularly pronounced within the caudal extent...
Influenza and pneumonia account for significant morbidity mortality, particularly in older individuals. Previous studies have shown that spousal caregivers of patients with dementia poorer antibody virus specific T cell responses to an influenza vaccine relative noncaregiving control subjects. This study tested the hypothesis stress can also significantly inhibit IgG response a pneumococcal bacterial vaccine.We measured titers current caregivers, former subjects after vaccination...
Stress-induced levels of plasma glucocorticoid hormones are known to modulate leukocyte function. These experiments examined the effects a social stressor on responsiveness peripheral immune cells. Male mice experienced six evening cycles disruption (SDR), in which an aggressive male intruder was placed into their home cage for 2 h. Although circulating corticosterone elevated SDR mice, they had enlarged spleens and increased numbers splenic leukocytes. Splenocytes from control were cultured...