A5005839191- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Immune cells in cancer
- Immune Response and Inflammation
- interferon and immune responses
- Dietary Effects on Health
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Wound Healing and Treatments
- Neonatal and fetal brain pathology
- Atherosclerosis and Cardiovascular Diseases
- Spinal Hematomas and Complications
- Cancer Research and Treatment
- Neurological Disease Mechanisms and Treatments
- Hemoglobinopathies and Related Disorders
- Otitis Media and Relapsing Polychondritis
- Safe Handling of Antineoplastic Drugs
- Iron Metabolism and Disorders
- Social and Intergroup Psychology
- Pressure Ulcer Prevention and Management
- Psychological and Temporal Perspectives Research
- Intravenous Infusion Technology and Safety
- Spinal Dysraphism and Malformations
University of Illinois Urbana-Champaign
2018-2024
The Ohio State University
2013-2024
The Ohio State University Wexner Medical Center
2015-2019
Institute for Behavioral Medicine
2013-2019
Society for Neuroscience
2016-2018
Traumatic brain injury (TBI) can lead to significant neuropsychiatric problems and neurodegenerative pathologies, which develop persist years after injury. Neuroinflammatory processes evolve over this same period. Therefore, we aimed determine the contribution of microglia neuropathology at acute [1 d postinjury (dpi)], subacute (7 dpi), chronic (30 dpi) time points. Microglia were depleted with PLX5622, a CSF1R antagonist, before midline fluid percussion (FPI) in male mice cortical...
Repeated social defeat (RSD) is a murine stressor that recapitulates key physiological, immunological, and behavioral alterations observed in humans exposed to chronic psychosocial stress. Psychosocial stress promotes prolonged adaptations are associated with neuroinflammatory signaling impaired neuroplasticity. Here, we show RSD promoted hippocampal activation was characterized by proinflammatory gene expression microglia monocyte trafficking particularly pronounced within the caudal extent...
Abstract Microglia undergo dynamic structural and transcriptional changes during the immune response to traumatic brain injury (TBI). For example, TBI causes microglia form rod‐shaped trains in cerebral cortex, but their contribution inflammation pathophysiology is unclear. The purpose of this study was determine origin alignment rod role propagating persistent cortical inflammation. Here, diffuse mice modeled by midline fluid percussion (FPI). Bone marrow chimerism BrdU pulse‐chase...
Psychosocial stress accelerates myelopoietic production of monocytes and neutrophils that contributes to a variety health complications ranging from atherosclerosis anxiety. Here, we show social in mice mobilizes hematopoietic stem progenitor cells (HSPCs) the bone marrow enter circulation, engraft into spleen, establish persistent extramedullary depot. These splenic progenitors actively proliferate differentiate multiple cell types, including monocytes, neutrophils, erythrocytes. Splenic...
Microglia are the resident innate immune cells of central nervous system. Limited turnover throughout lifespan leaves microglia susceptible to age-associated dysfunction. Indeed, we and others have reported develop a pro-inflammatory or "primed" profile with age, characterized by increased expression inflammatory mediators (e.g., MHC-II, CD68, IL-1β). Moreover, challenge lipopolysaccharide (LPS) causes an exaggerated prolonged neuroinflammatory response mediated primed in aged brain. Recent...
Clinical studies indicate that psychosocial stress contributes to adverse chronic pain outcomes in patients, but it is unclear how this initiated or amplified by stress. Repeated social defeat (RSD) a mouse model of activates microglia, increases neuroinflammatory signaling, and augments anxiety-like behaviors. We hypothesized activated microglia within the spinal cord facilitate increased sensitivity following RSD. Here we show mechanical allodynia male mice was with exposure This...
Interleukin-1 (IL-1) mediates diverse neurophysiological and neuropathological effects in the CNS through type I IL-1 receptor (IL-1R1). However, identification of IL-1R1-expressing cell types cell-type-specific functions IL-1R1 remains challenging. In this study, we created a novel genetic mouse model which gene expression is disrupted by an intronic insertion loxP flanked disruptive sequence that can be deleted Cre recombinase, resulting restored under its endogenous promoters. A second...
Recent evidence indicates that inflammatory insults in neonates significantly influenced white matter development and caused behavioral deficits manifest young adulthood. The mechanisms underlying these developmental complications, however, are not well understood. We hypothesize acute brain inflammation by neonatal infection reduces the bioavailability of iron required for oligodendrocyte maturation development. Here, we confirm peripheral Escherichia coli at postnatal day 3 (P3) was...
Spinal cord injury (SCI) produces a toxic inflammatory microenvironment that negatively affects plasticity and recovery. Recently, we showed glial activation peripheral myeloid cell infiltration extending beyond the epicenter through remote lumbar after thoracic SCI. The presence role of infiltrating monocytes is important, especially in where locomotor central pattern generators are housed. Therefore, compared profile resident microglia cells Bone marrow chimeras received midthoracic...
Abstract Background Recent data suggest that myelin may be altered by physiological events occurring outside of the central nervous system, which cause changes to cognition and behavior. Similarly, peripheral infection non-neurotropic viruses is also known evoke Methods Mice were inoculated with saline or influenza A virus. Bulk RNA-seq, lipidomics, RT-qPCR, flow cytometry, immunostaining, western blots used determine effect on OL viability, protein expression lipidome. To if microglia...
Inflammation of the fat in lupus erythcmatosus also known as erythematosus profundus (panniculitis) is a rare clinical entity. As presenting feature lupus, it even more unusual. In this report, we describe an elderly woman who presented with orbital mass infiltrate initial manifestation that had classic histological features panniculitis.
Microglia activation and proliferation are hallmarks of many neurodegenerative disorders may contribute to disease pathogenesis. Neurons actively regulate microglia survival function, in part by secreting the mitogen interleukin (IL)-34. Both IL-34 colony stimulating factor (CSF)-1 bind receptor (CSFR)1 expressed on microglia. Systemic treatment with central nervous system (CNS) penetrant, CSFR1 antagonists, results death a dose dependent matter, while others, such as GW2580, suppress during...