A5046597190- Cancer, Stress, Anesthesia, and Immune Response
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Optimism, Hope, and Well-being
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Neuropeptides and Animal Physiology
- Inflammatory mediators and NSAID effects
- Neuroendocrine regulation and behavior
- Psychological Well-being and Life Satisfaction
- Cancer survivorship and care
- Early Childhood Education and Development
- Nanoplatforms for cancer theranostics
- Sleep and related disorders
- Circadian rhythm and melatonin
- Cancer-related cognitive impairment studies
- Hematopoietic Stem Cell Transplantation
- Mental Health Research Topics
- Cytokine Signaling Pathways and Interactions
- Childhood Cancer Survivors' Quality of Life
- Resilience and Mental Health
- Pediatric Pain Management Techniques
- Health, psychology, and well-being
- Virus-based gene therapy research
- Reproductive System and Pregnancy
Black AIDS Institute
2023
University of California, Los Angeles
2014-2023
Neurobehavioral Systems
2012-2021
UCLA Jonsson Comprehensive Cancer Center
2010-2018
University of Colorado Denver
2016
University of Colorado Cancer Center
2016
UCLA Health
2014
West Los Angeles College
2013
Salk Institute for Biological Studies
2012
Children's Hospital of Los Angeles
2002-2008
Metastasis to distant tissues is the chief driver of breast cancer-related mortality, but little known about systemic physiologic dynamics that regulate this process. To investigate role neuroendocrine activation in cancer progression, we used vivo bioluminescence imaging track development metastasis an orthotopic mouse model cancer. Stress-induced had a negligible effect on growth primary tumor induced 30-fold increase including lymph nodes and lung. These effects were mediated by...
Abstract Background Social environmental influences on human health are well established in the epidemiology literature, but their functional genomic mechanisms unclear. The present study analyzed genome-wide transcriptional activity people who chronically experienced high versus low levels of subjective social isolation (loneliness) to assess alterations transcription control pathways that might contribute increased adverse outcomes isolates. Results DNA microarray analysis identified 209...
Significance Chronic exposure to adverse social environments is associated with increased risk of disease, and stress-related increases in the expression proinflammatory genes appear contribute these effects. The present study identifies a biological mechanism such effects ability sympathetic nervous system up-regulate bone marrow production immature, monocytes. These are mediated by β-adrenergic receptors myelopoietic growth factor GM-CSF, suggest new targets for interventions protect...
To identify molecular mechanisms underlying the prospective health advantages associated with psychological well-being, we analyzed leukocyte basal gene expression profiles in 80 healthy adults who were assessed for hedonic and eudaimonic as well potentially confounded negative behavioral factors. Hedonic well-being showed similar affective correlates but highly divergent transcriptome profiles. Peripheral blood mononuclear cells from people high levels of up-regulated a stress-related...
BACKGROUND Premenopausal women diagnosed with breast cancer are at risk for psychological and behavioral disturbances after treatment. Targeted interventions needed to address the needs of this vulnerable group. METHODS This randomized trial provided first evaluation a brief, mindfulness‐based intervention younger survivors designed reduce stress, depression, inflammatory activity. Women early stage or before age 50 who had completed treatment were randomly assigned 6‐week Mindful Awareness...
Significance Perceived social isolation (PSI) (loneliness) is linked to increased risk of chronic disease and mortality, previous research has implicated up-regulated inflammation down-regulated antiviral gene expression (the conserved transcriptional response adversity; CTRA) as a potential mechanism for such effects. The present studies used integrative analyses transcriptome regulation in high-PSI humans rhesus macaques define the basis effects neuroendocrine-related alterations myeloid...
To clarify the biological rationale for social regulation of gene expression, this study sought to identify specific immune cell types that are transcriptionally sensitive subjective isolation (loneliness). Using reference distributions expression each human in major leukocyte subtype, we mapped cellular origin transcripts found be differentially expressed circulating cells from chronically lonely individuals. Loneliness-associated genes derived primarily plasmacytoid dendritic cells,...
Abstract Purpose: Translational studies suggest that excess perioperative release of catecholamines and prostaglandins may facilitate metastasis reduce disease-free survival. This trial tested the combined blockade these pathways in breast cancer patients. Experimental Design: In a randomized placebo-controlled biomarker trial, 38 early-stage patients received 11 days treatment with β-adrenergic antagonist (propranolol) COX-2 inhibitor (etodolac), beginning 5 before surgery. Excised tumors...
Research in human social genomics has identified a conserved transcriptional response to adversity (CTRA) characterized by up-regulated expression of pro-inflammatory genes and down-regulated Type I interferon- antibody-related genes. This report seeks identify the specific aspects positive psychological well-being that oppose such effects predict reduced CTRA gene expression. In new confirmation study 122 healthy adults replicated approach previously reported discovery study, mixed effect...
To identify genetic factors that interact with social environments to impact human health, we used a bioinformatic strategy couples expression array-based detection of environmentally responsive transcription in silico discovery regulatory polymorphisms predict loci modulate transcriptional responses stressful environments. Tests one predicted interaction locus the IL6 promoter (SNP rs1800795) verified it modulates response beta-adrenergic activation GATA1 factor vitro. In vivo validation...
To identify molecular mechanisms by which early life social conditions might influence adult risk of disease in rhesus macaques ( Macaca mulatta ), we analyze changes basal leukocyte gene expression profiles 4-mo-old animals reared under adverse conditions. Compared with the condition maternal rearing (MR), leukocytes from peer-reared (PR) and PR provided an inanimate surrogate mother (surrogate/peer reared, SPR) show enhanced genes involved inflammation, cytokine signaling, T-lymphocyte...
Purpose Evidence has supported the association between psychological factors and cancer biology; however, findings are equivocal on role of psychosocial in progression. This study generates a hypothesis mechanistic variables by examining clinical effects cortisol dysregulation patients with metastatic renal cell carcinoma (RCC) examines associated activation transcription control pathways. Methods Patients RCC (n = 217) were prospectively enrolled this study. completed questionnaires...
A growing number of studies indicate that chronic stress can accelerate tumor growth due to sustained sympathetic nervous system activation. Our recent findings suggest is associated with increased IL8 levels. Here, we examined the molecular and biological significance in stress-induced growth. Norepinephrine (NE) treatment ovarian cancer cells resulted a 250–300% increase protein 240–320% its mRNA Epinephrine similar increases. Moreover, NE 3.5–4-fold promoter activity. These effects were...
Abstract Purpose: Stromal cells in the tumor microenvironment, such as macrophages, play an active role growth and angiogenesis. However, little is known about relationships of biobehavioral factors with angiogenic cytokines matrix metalloproteinases (MMP) produced by stromal cells. This study examined distress, MMPs, ovarian cancer patients vitro. Experimental Design: Patients suspected completed preoperative questionnaires. At surgery, 56 were confirmed to have epithelial cancer. Tumor...
Mind–body therapies such as Tai Chi are widely used by breast cancer survivors, yet effects on inflammation not known. This study hypothesized that Chih (TCC) would reduce systemic, cellular, and genomic markers of compared with cognitive behavioral therapy for insomnia (CBT-I). In this randomized trial the treatment insomnia, 90 survivors were assigned to TCC or CBT-I 2-hour sessions weekly 3 months. At baseline postintervention, blood samples obtained measurement C-reactive protein...