We examined whether the magnitude of plasma oxytocin (OT), norepinephrine (NE), cortisol, and blood pressure (BP) responses before after a brief episode warm contact (WC) with spouse/partner may be related to strength perceived partner support.Subjects were 38 cohabiting couples (38 men, women) aged 20 49 years. All underwent 10 minutes resting baseline alone, WC together their partner, postcontact rest alone.Greater support (based on self-report) was higher in men women across protocol WC....

To identify molecular mechanisms underlying the prospective health advantages associated with psychological well-being, we analyzed leukocyte basal gene expression profiles in 80 healthy adults who were assessed for hedonic and eudaimonic as well potentially confounded negative behavioral factors. Hedonic well-being showed similar affective correlates but highly divergent transcriptome profiles. Peripheral blood mononuclear cells from people high levels of up-regulated a stress-related...

Background: Postpartum depression is associated with reduced breastfeeding duration. We previously hypothesized that shared neuroendocrine mechanisms underlie this association. sought to measure the association between maternal mood and response breastfeeding. Methods: conducted a longitudinal cohort study of women recruited during pregnancy who intended breastfeed. Baseline anxiety history were assessed structured clinical interview. measured symptoms using validated psychometric...

Research in human social genomics has identified a conserved transcriptional response to adversity (CTRA) characterized by up-regulated expression of pro-inflammatory genes and down-regulated Type I interferon- antibody-related genes. This report seeks identify the specific aspects positive psychological well-being that oppose such effects predict reduced CTRA gene expression. In new confirmation study 122 healthy adults replicated approach previously reported discovery study, mixed effect...

Abstract The authors investigated the relationship between brief warm social and physical contact among cohabitating couples blood pressure (BP) reactivity to stress in a sample of healthy adults (66 African American, 117 Caucasian; 74 women, 109 men). Prior stress, group underwent 10-minute period handholding while viewing romantic video, followed by 20-second hug with their partner, no rested quietly for 10 minutes 20 seconds. In response public speaking task, individuals receiving...

Never or curtailed lactation has been associated with an increased risk for incident hypertension, but the effect of exclusive breastfeeding is unknown. The authors conducted observational cohort study 55,636 parous women in US Nurses’ Health Study II. From 1991 to 2005, participants reported 8,861 cases hypertension during 660,880 person-years follow-up. was hypertension. Compared who breastfed their first child ≥12 months, did not breastfeed were more likely develop (hazard ratio (HR) =...

Oxytocin (OT) is a peptide increasingly studied in relation to human social interactions, affiliation, and clinical disorders. Studies are constrained by use of invasive blood draws would benefit from reliable salivary OT assay. Our goals were examine feasibility measurement, compare plasma responses 12 breast- 8 formula-feeding mothers, assess the degree correlation between OT. Using commercial EIA kit, we measured 5 saliva 7 samples protocol designed elicit changes (Rest, Infant...

We addressed the question how long salivary oxytocin levels remain elevated after intranasal administration, and whether it makes a difference when 16 or 24 IU of administration is used. Oxytocin were measured in saliva samples collected from 46 female participants right before (at 9:30 a.m.) (n = 18) 10) oxytocin, placebo 18), each hour for 7 h total. did not differ among conditions use nasal spray. Salivary group showed high stability across day. After markedly increased, they peaked...

Breastfeeding durations in the United States fall short of public health objectives. We sought to quantify prevalence and identify risk factors for early, undesired weaning that mothers attribute physiologic difficulties with breastfeeding.

In the early postpartum period, mother and infant navigate a critical neuroendocrine transition from pregnancy to lactation. Two major clinical problems that occur during this are failed lactation perinatal mood disorders. These disorders often overlap in settings. Failed is common. Although all medical organizations recommend 6 months of exclusive breastfeeding, only 13% women United States achieve recommendation. Perinatal affect 10% mothers, with substantial morbidity for child. We...

Prenatal drug exposure, particularly prenatal cocaine exposure (PCE), incurs great public and scientific interest because of its associated neurodevelopmental consequences. However, the neural underpinnings PCE remain essentially uncharted, existing studies in school-aged children adolescents are confounded greatly by postnatal environmental factors. In this study, leveraging a large neonate sample ( N = 152) non-invasive resting-state functional magnetic resonance imaging, we compared human...

In this research, we tested hypotheses about the role of oxytocin in adult human bonding. Inspired by revisiting research on pair bonding microtine voles that fueled psychologists’ interest social life, drew recent theory from affective and relationship science to identify a well-defined context for romantic relationships. We then paired these behaviors subjective psychological responses with measure naturally circulating oxytocin. 129 romantically involved adults whose partner expressed...

Purpose: We sought to determine the role of depression and anxiety in breastfeeding cessation. Materials Methods: Participants underwent a baseline visit with structured clinical interview third trimester pregnancy. Monthly phone interviews assessed current mood symptoms infant feeding status. association between outcomes using Cox proportional hazards regression, adjusting for intention sociodemographic confounders. Results: enrolled 222 mother-infant dyads late pregnancy, whom 206...

Abstract Perinatal perceived stress can contribute to worse health outcomes for the parent–child dyad. Given emerging relationship between microbiota-gut-brain axis and stress, this study sought elucidate connections bowel symptoms gut microbiome in relation at three time points perinatal period: two during pregnancy one postpartum. Ninety-five pregnant individuals participated a prospective cohort from April 2017 November 2019. Researchers assessed Perceived Stress Scale-10 (PSS);...

Prenatal marijuana exposure (PME) is linked to neurobehavioral and cognitive impairments; however, findings in childhood adolescence are inconsistent. Type-1 cannabinoid receptors (CB1R) modulate fetal neurodevelopment, mediating PME effects on growth of functional circuitry sub-serving behaviors critical for academic social success. The purpose this study was investigate the prenatal development early brain prior prolonged postnatal environmental influences. We measured resting state...