A5100402740- Extracellular vesicles in disease
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- MicroRNA in disease regulation
- Bone and Joint Diseases
- Wound Healing and Treatments
- Heavy metals in environment
- Circular RNAs in diseases
- Graphene and Nanomaterials Applications
- Mesenchymal stem cell research
- Bone Metabolism and Diseases
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Nanoparticles: synthesis and applications
- Autophagy in Disease and Therapy
- Bone Tissue Engineering Materials
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Dietary Effects on Health
- Cancer, Hypoxia, and Metabolism
- Heavy Metal Exposure and Toxicity
- Arsenic contamination and mitigation
- Ion Transport and Channel Regulation
- Geochemistry and Geologic Mapping
- Long-Term Effects of COVID-19
Xiangya Hospital Central South University
2017-2025
Central South University
2011-2025
Union Hospital
2024
Huazhong University of Science and Technology
2024
East China University of Science and Technology
2023
Changsha University
2020
University of Rome Tor Vergata
2018
Southwest University
2018
East China Normal University
2018
The application of blood plasma for soft tissue wound healing is receiving much more attention recently. Exosomes are critical paracrine mediators that can be obtained from biological fluids including and able to induce regenerative effects by transferring bioactive molecules such as microRNAs (miRNAs). This study aimed investigate the exosomes human umbilical cord (UCB-Exos) on elucidate underlying mechanism. Methods: UCB-Exos were isolated ultracentrifugation subcutaneously injected into...
Chronic non-healing wounds represent one of the most common complications diabetes and need advanced treatment strategies. Exosomes are key mediators cell paracrine action can be directly utilized as therapeutic agents for tissue repair regeneration. Here, we explored effects exosomes from human urine-derived stem cells (USC-Exos) on diabetic wound healing underlying mechanism. Methods: USCs were characterized by flow cytometry multipotent differentiation potential analyses. USC-Exos...
A novel strategy to deliver therapeutic exosomes bone is developed for the first time by conjugating a specific BMSC-targeting aptamer exosomal surface.
L-AgÅPs-gel represents a highly effective and safe antibacterial anti-inflammatory material for promoting wound healing.
Recently, the gut microbiota (GM) has been shown to be a regulator of bone homeostasis and mechanisms by which GM modulates mass are still being investigated. Here, it is found that colonization with from children (CGM) but not elderly (EGM) prevents decreases in strength conventionally raised, ovariectomy (OVX)-induced osteoporotic mice. 16S rRNA gene sequencing reveals CGM reverses OVX-induced reduction Akkermansia muciniphila (Akk). Direct replenishment Akk sufficient correct imbalanced...
Adipocyte differentiation of bone marrow mesenchymal stem/stromal cells (BMSCs) instead osteoblast formation contributes to age- and menopause-related adiposity osteoporosis. Vascular calcification often occurs with osteoporosis, a contradictory association called "calcification paradox". Here we show that extracellular vesicles derived from aged matrix (AB-EVs) during resorption favor BMSC adipogenesis rather than osteogenesis augment vascular smooth muscle cells. Intravenous or...
Abstract Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in the pro-inflammatory cytokines make an important contribution to bone loss by promoting resorption impairing formation. Omentin-1 newly identified adipocytokine that has anti-inflammatory effects, but little known about role omentin-1 osteoporosis. Here we generated global knockout ( −/− ) mice demonstrated depletion induces loss-like phenotypes mice, as defined abnormally elevated cytokines,...
Osteoporosis and osteoporotic fractures severely compromise quality of life in elderly people lead to early death. Human umbilical cord mesenchymal stromal cell (MSC)-derived extracellular vesicles (hucMSC-EVs) possess considerable therapeutic effects tissue repair regeneration. Thus, the present study, we investigated hucMSC-EVs on primary secondary osteoporosis explored underlying mechanisms. Methods: hucMSCs were isolated cultured. EVs obtained from conditioned medium determined by using...
Senile osteoporosis (OP) is often concomitant with decreased autophagic activity. OPTN (optineurin), a macroautophagy/autophagy (hereinafter referred to as autophagy) receptor, found play pivotal role in selective autophagy, coupling autophagy bone metabolism. However, its osteogenesis still mysterious. Herein, we identified Optn critical molecule of cell fate decision for marrow mesenchymal stem cells (MSCs), whose expression aged mice. Aged mice revealed osteoporotic loss, elevated...
Alzheimer's disease (AD) is currently ranked as the third leading cause of death for eldly people, just behind heart and cancer. Autophagy declined with aging. Our study determined biphasic changes miR-331-3p miR-9-5p associated AD progression in APPswe/PS1dE9 mouse model demonstrated inhibiting treatment prevented by promoting autophagic clearance amyloid beta (Aβ). Methods: The microRNAs were obtained from RNA-seq data verified qRT-PCR early-stage (6 months) late-stage (12 mice...
Purpose: Prostate cancer (PCa) is one of the most common malignancies in males. Despite success immunotherapy many malignant cancers, strategies are still needed to improve therapeutic efficacy PCa. This study aimed investigate effects Akkermansia muciniphila -derived extracellular vesicles ( Akk -EVs) on PCa and elucidate underlying immune-related mechanism. Methods: -EVs were isolated by ultracentrifugation intravenously injected treat syngeneic PCa-bearing immune-competent mice....
Abstract Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells (USCs), which were noninvasively harvested from unlimited and easily available urine, as “factory” to obtain extracellular vesicles (USC-EVs) demonstrated that the systemic injection USC-EVs effectively alleviates loss maintains strength in osteoporotic mice by enhancing osteoblastic formation suppressing osteoclastic resorption. More importantly, anti-osteoporotic...
Poor wound healing affects millions of people worldwide each year and needs better therapeutic strategies.Synechococcus elongatus PCC 7942 is a naturally occurring photoautotrophic cyanobacterium that can be easily obtained large-scale expanded.Here, we investigated the efficacy this in mouse model acute burn injury whether secretion extracellular vesicles (EVs), important mediators cell paracrine activity, key mechanism cyanobacterium-induced regulation healing.Methods: The effects...
Abstract Both Alzheimer's disease (AD) and osteoporosis (OP) are common age‐associated degenerative diseases strongly correlated with clinical epidemiology. However, there is a lack of clear pathological relationship between the brain bone in current understanding. Here, it found that young osteocyte, most abundant cells bone, secretes extracellular vesicles (OCY Young ‐EVs) to ameliorate cognitive impairment pathogenesis AD APP/PS1 mice model cells. These benefits OCY ‐EVs diminished aged...
Abstract The µW‐level power density of flexible piezoelectric energy harvesters (FPEHs) restricts their potential in applications related to high‐power multifunctional wearable devices. To overcome this challenge, a hierarchical design strategy is proposed by forming porous piezoceramics with an optimum microstructure into ordered macroscopic array structure enable the construction high performance FPEHs. piezoceramic elements allows optimization sensing and harvesting Figure merit, causes...
Inadequate osteogenesis and excessive adipogenesis of bone marrow mesenchymal stem cells (BMSCs) are key factors in the pathogenesis osteoporosis.Patients with Alzheimer's disease (AD) have a higher incidence osteoporosis than healthy adults, but underlying mechanism is not clear.Here, we show that brain-derived extracellular vesicles (EVs) from adult AD or wild-type mice can cross blood-brain barrier to reach distal tissue, while only EVs (AD-B-EVs) significantly promote shift BMSC...
Abstract Neurodegenerative diseases (NDDs) such as Alzheimer’s disease, Parkinson’s and amyotrophic lateral sclerosis epitomize a class of insidious relentless neurological conditions that are difficult to cure. Conventional therapeutic regimens often fail due the late onset symptoms, which occurs well after irreversible neurodegeneration has begun. The integrity blood-brain barrier (BBB) further impedes efficacious drug delivery central nervous system, presenting formidable challenge in...
Due to increasing morbidity worldwide, fractures are becoming an emerging public health concern. This study aimed investigate the effect of metformin on healing osteoporotic as well normal fractures. Type H vessels have recently been identified a bone-specific vascular subtype that supports osteogenesis. Here, we show accelerated fracture in both and mice. Moreover, promoted angiogenesis vitro under hypoxia type vessel formation throughout healing. Mechanistically, increased expression...
Heavy metal pollutants in soils can usually enter the human body and pose heath risks through a soil-crop-human pathway (indirect exposure) or soil-human (direct exposure). Previous studies often neglected direct exposure health risk assessment, especially for children. We collected surface soil samples from urban suburb areas Changsha City, China, to analyze content ofAs, Cd, Hg, Ni, Pb, Zn. A combination of principal component analysis, geostatistics, triangulated irregular network (TIN)...