A5068213299- Pancreatic function and diabetes
- Diabetes Management and Research
- Diabetes and associated disorders
- Birth, Development, and Health
- Growth Hormone and Insulin-like Growth Factors
- Spinal Cord Injury Research
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Genomic variations and chromosomal abnormalities
- Diet and metabolism studies
- Advanced biosensing and bioanalysis techniques
- Metabolism, Diabetes, and Cancer
- Covalent Organic Framework Applications
- Energy, Environment, Economic Growth
- Bone health and osteoporosis research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Hypothalamic control of reproductive hormones
- Thyroid Disorders and Treatments
- Biosensors and Analytical Detection
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Electrochemical sensors and biosensors
- Nutrition, Genetics, and Disease
- Gout, Hyperuricemia, Uric Acid
- Cerebrovascular and genetic disorders
Children's Hospital of Zhejiang University
2011-2025
Academy of Medical Sciences
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
China-Japan Friendship Hospital
2025
National Clinical Research
2025
Luoyang Central Hospital Affiliated to Zhengzhou University
2020-2025
Nanchang University
2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2024
First Affiliated Hospital of Jinan University
2024
Sichuan Normal University
2024
Autonomic dysreflexia (AD), a potentially dangerous complication of high-level spinal cord injury (SCI) characterized by exaggerated activation autonomic (sympathetic) reflexes, can cause pulmonary embolism, stroke, and, in severe cases, death. People with SCI also are immune compromised, rendering them more susceptible to infectious morbidity and mortality. The mechanisms underlying postinjury suppression not known. Data presented herein indicate that AD causes suppression. Using <i>in...
Abstract Spinal cord injury (SCI) leads to secondary neuronal death, which severely impedes recovery of motor function. Therefore, prevention cell death after SCI is an important strategy. Ferroptosis, a new form discovered in recent years, has been shown be involved the regulation SCI. However, role and potential mechanisms ferroptosis are not fully understood. In this study, we report that E3 ubiquitin ligase Syvn1 suppresses promotes functional from vitro vivo. Mechanistically, screened...
Abstract Context The evidence of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric deficiency (GHD) is limited. Objective This study aimed to examine the effectiveness and safety PEG-rhGH children with GHD real world, as well effects dose on patient outcomes. Design A prospective, observational, posttrial (NCT03290235). Setting, participants intervention Children were enrolled from 81 centers China 4 individual clinical trials received weekly 0.2 mg/kg/wk (high-dose)...
Abstract Context Age of pubertal onset has been decreasing in many countries but there have no data on development Chinese children over the last decade. Objective The primary objective study was to evaluate current status sexual maturation and adolescents. Secondary objectives were examine socioeconomic, lifestyle, auxological associations with onset. Methods In this national, cross-sectional, community-based health survey, a multistage, stratified cluster random sampling method used select...
This study investigated the impact of coronavirus disease 2019 (COVID-19) pandemic and its associated restrictive measures on Mycoplasma pneumoniae infections in children with acute respiratory tract infection. The aimed to elucidate epidemiological characteristics M. before during following easing measures. Pharyngeal secretions were collected from 1,0174 pediatric patients infection (ARI) who admitted Shaoxing Maternity Child Health Care Hospital (Shaoxing, China) between May 2018 December...
Quantifying the disease burden among children that could potentially be reduced through improvements in individual economic status and regional equality can greatly benefit policy making resource allocation. However, such quantification has rarely been done. This study aimed to assess inequality-related of acute respiratory infection (ARI) (the leading cause child mortality low- middle-income countries (LMICs)) under five children. integrated Demographic Health Survey data from 53 linked...
Abstract The northwest-trending Altai Mountains of central Asia expose a complex network thrust and strike-slip faults that are key features accommodating intracontinental crustal shortening related to the Cenozoic India-Asia collision. In this study, we investigated Quaternary slip history Fuyun fault, right-lateral fault bounding southwestern margin Mountains, through geologic mapping, geomorphic surveying, optically stimulated luminescence (OSL) geochronology. At Kuoyibagaer site,...
Abstract Diabetes mellitus (DM) is a common chronic disease affecting humans globally. It characterized by abnormally elevated blood glucose levels due to the failure of insulin production or reduction sensitivity and functionality. Insulin glucagon‐like peptide (GLP)‐1 replenishment improvement resistance are two major strategies treat diabetes. Recently, optogenetics that uses genetically encoded light‐sensitive proteins precisely control cell functions has been regarded as novel...
Bone Marrow mesenchymal Stem Cells (BMSCs) are considered as an important source of cells for regenerative medicine, In particular, Exosomes (BMSCs-EXO) have the most significant effect in treatment Spinal Cord Injury (SCI), but mechanism action is still unknown. This study found that compared with other SCI groups, BMSCs-EXO loaded miR-146a could significantly improve functional recovery hind limbs rats. Hematoxylin and eosin (H&E) indicated lesion area spinal cord injury was less, nissl...
Abstract Context Although gonadotropin-releasing hormone stimulation test (GnRHST) is the gold standard in diagnosing central precocious puberty (CPP), it invasive, expensive, and time-consuming, requiring multiple blood samples to measure gonadotropin levels. Objective We evaluated whether urinary hormones could be potential biomarkers for prepuberty or postpuberty, aiming simplify current diagnosis prognosis procedure. Methods performed a cross-sectional study of total 355 girls with CPP...
Objective The aim of this study was to assess the efficacy and safety Diascorea alata for treatment menopausal symptoms.Materials methods Two-center, randomized, double-blind, placebo-controlled clinical investigation on 50 women randomly assigned two groups, treated 12 months with either placebo or sachets daily extracts containing mg/sachet. Primary outcome measures were changes in Greene Climacteric Scale caused by compared placebo; secondary outcomes plasma hormone profiles. One-way...
Objective: To investigate the status of height and weight 3-18-year-old children adolescents in urban China, to provide a basis for establishing puberty phase specific curves age-specific weight. Methods: A cross-sectional survey 218 185 aged 3-18 years China was conducted by using method stratified random cluster sampling from January 2017 December 2019. The areas included 12 provinces municipalities autonomous regions total. Data were collected on weight, height, waist circumference, hip...
Summary Objective We examined the associations between maternal age at menarche and anthropometry metabolism in adolescent offspring. Methods Anthropometric, metabolic blood pressure data were obtained from 304 girls 190 boys aged 11‐16 years attending school Hangzhou (China). Age for both mothers daughters was self‐reported. Fasting samples all participants underwent clinical examinations. Obesity defined as BMI ≥95th percentile sex. Results Older associated with older of their ( r = 0.21;...
Childhood obesity is rapidly rising in China and effective diet interventions are needed. Here, we determine whether the Chinese government-recommended (GRD) or a modified of further restriction sugar ultra-processed food but without energy restriction, minimally processed (MPD) on weight loss children adolescents with obesity/overweight.This open-label, randomized study included 60 between 5-18 years old overweight/obesity. Participants were 1:1 to GRD MPD self-managed at home for 12 weeks....