A5008797388- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Gut microbiota and health
- Child Nutrition and Feeding Issues
- MicroRNA in disease regulation
- Breastfeeding Practices and Influences
- Hepatitis C virus research
- HIV-related health complications and treatments
- Liver Disease Diagnosis and Treatment
- Infant Health and Development
- HIV/AIDS Research and Interventions
- Health, psychology, and well-being
- Infant Development and Preterm Care
- Gastroesophageal reflux and treatments
- Cancer-related molecular mechanisms research
- Child Nutrition and Water Access
- Viral gastroenteritis research and epidemiology
- Pediatric Pain Management Techniques
- Maternal Mental Health During Pregnancy and Postpartum
- Hepatitis B Virus Studies
- Eating Disorders and Behaviors
- Dermatology and Skin Diseases
- Diet, Metabolism, and Disease
- Pneumocystis jirovecii pneumonia detection and treatment
- Musculoskeletal pain and rehabilitation
University of Pennsylvania
2024-2025
University of Connecticut
2019-2024
Durham VA Health Care System
2023
Peking University
2022
Henderson Community College
2015-2022
National Institute of Nursing Research
2010-2020
National Institutes of Health
2009-2020
Saint Leo University
2020
University of Maryland, Baltimore
2019
University of Delaware
2019
Gut microbiota plays a key role in multiple aspects of human health and disease, particularly early life. Distortions the gut have been found to correlate with fatal diseases preterm infants, however, developmental patterns microbiome factors affecting colonization progress infants remain unclear. The purpose this prospective longitudinal study was explore day-to-day during their first 30 days life neonatal intensive care unit (NICU) investigate potential related development infant...
Abstract Evidence highlights the comorbidity between emotional distress and irritable bowel syndrome (IBS) through gut-brain axis. However, underlying mechanism is largely unknown. Thus, present study aimed to evaluate associations among neurotransmitter levels gut microbiome profiles in persons with IBS distress. In this nested case-controlled study, symptoms, including anxiety depressive were evaluated 40 20 healthy controls (HC). Plasma neurotransmitters (serotonin norepinephrine) profile...
: Irritable bowel syndrome (IBS) is a common, chronic gastrointestinal (GI) condition characterized by disturbances in habits and abdominal pain the absence of known organic pathology. IBS reduces quality life costly to treat. It diagnosed using symptom-based Rome criteria for functional GI disorders, which was recently updated released as IV. Both physiologic psychological variables play role etiology perpetuate symptoms. Although research has shed light on pathophysiology, therapeutic...
To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome (IBS).A database search for relevant was conducted using PubMed, Scopus Embase February 2015. Date filters were applied from year 2009 onward, studies limited to those written English language performed upon human subjects. The initial yielded 797 articles, out of which 38 pulled full text review 27 included study analysis. Investigations reviewed determine design,...
Irritable bowel syndrome (IBS) is a poorly understood disorder characterized by persistent symptoms, including visceral pain. Studies have demonstrated oral microbiome differences in inflammatory diseases suggesting the potential of study non-oral conditions.In this exploratory we examine whether exist IBS participants and healthy controls, relates to symptom severity.The buccal mucosal 38 was using PhyloChip microarrays. The severity pain assessed orally administering gastrointestinal test...
Catastrophizing is a cognitive process characterized by propensity to concentrate on and magnify the value of an actual or anticipated painful stimulus negatively assesses one's ability cope. important predictor pain-related outcomes. A cornerstone symptom irritable bowel syndrome (IBS) abdominal pain discomfort. Also individuals with IBS have been reported tendency catastrophize. In sample who suffer from IBS, we hypothesized that those catastrophize (catastrophizers) would worse outcomes...
The mechanisms underlying the transition from acute to chronic pain remain unclear. Here, we sought characterize transcriptome associated with low back as well of pain. For analysis, compared whole blood of: (a) patients at onset who no longer had within 6 weeks after (acute) developed months (chronic T5); and, (b) T1) healthy pain-free (normal) controls. majority differentially expressed genes were protein coding. We illustrate a unique characterized by significant enrichment for known...
Hepatitis C virus (HCV) infection induces interferon (IFN)-stimulated genes (ISGs) and downstream innate immune responses. This study investigated whether baseline on-treatment differences in these responses predict response versus virological breakthrough during therapy with direct-acting antivirals (DAAs). Thirteen HCV genotype 1b-infected patients who had previously failed a course of pegylated IFN/ribavirin were retreated asunaprevir/daclatasvir for 24 weeks. After pretreatment biopsy,...
Wearable devices for continuous health monitoring in humans are constantly evolving, yet the signal quality may be improved by optimizing electrode placement. While commonly used locations to measure electrodermal activity (EDA) at fingers or wrist, alternative locations, such as torso, need considered when applying an integrated multimodal approach of concurrently recording multiple bio-signals, visceral pain symptoms like those related irritable bowel syndrome (IBS). This study aims...
Precision health is a person-centered approach to and well-being that operationalized through evaluating omics-level profiles their associations with the exposome. A precision addresses challenge "one size does not fit all" in management of an individual's health. The purpose this white paper introduce Health Model its application research clinical care. An expert panel reviewed synthesized extant literature related health, current state omics' science, common exposome factors influence...
Poor sleep and stress are more frequently reported by women with irritable bowel syndrome (IBS) than healthy control (HC) women. The pathophysiology linking poor to gastrointestinal symptoms remains poorly understood. We used a metabolomic approach determine whether tryptophan (TRP) metabolites differ between without IBS the levels associated indices serum cortisol levels. This study sample included 38 21 HCs. were studied in laboratory for three consecutive nights. On third night of study,...