A5073263928- Gastrointestinal motility and disorders
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Health, psychology, and well-being
- Diet and metabolism studies
- Sports and Physical Education Research
- Neuroscience and Music Perception
- Children's Physical and Motor Development
- Sleep and related disorders
- Gut microbiota and health
- Sleep and Work-Related Fatigue
- MicroRNA in disease regulation
- Music Therapy and Health
- Gastrointestinal disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Eating Disorders and Behaviors
- Esophageal and GI Pathology
- Microscopic Colitis
- Biliary and Gastrointestinal Fistulas
- Dermatology and Skin Diseases
- Musculoskeletal pain and rehabilitation
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer survivorship and care
- Hedgehog Signaling Pathway Studies
University of Maryland, Baltimore
2019-2022
National Institute of Nursing Research
2016-2020
National Institutes of Health
2016-2020
Cornell University
2012-2019
Children's Hospital of Pittsburgh
2019
Neurological Surgery
2019
Weill Cornell Medicine
2019
New York University
2015-2018
Johns Hopkins University
2018
University of Newcastle Australia
2012
Many breast cancer survivors have coexistent chronic diseases or comorbidities at the time of their diagnosis. The purpose study was to evaluate association on survivors' quality life. A prospective design used recruit 140 women before surgery, 134 completed study. Comorbidities were assessed using self-report and verified by medical record review Charlson Comorbidity Index (CCI) 12-month after surgery. Quality life evaluated Short-Form Health Survey (SF-36 v2). Descriptive statistics,...
Performing endoscopic retrograde cholangiopancreatography (ERCP) in patients who have undergone Rouxen-Y gastric bypass (RYGB) is challenging. Standard ERCP and enteroscopy-assisted are associated with limited success rates. Laparoscopy- or laparotomy-assisted yields improved efficacy rates, but higher complication rates costs. We present the first multicenter experience regarding safety of ultrasound (EUS)-directed transgastric (EDGE) EUS.All underwent EDGE at two academic centers were...
: Irritable bowel syndrome (IBS) is a common, chronic gastrointestinal (GI) condition characterized by disturbances in habits and abdominal pain the absence of known organic pathology. IBS reduces quality life costly to treat. It diagnosed using symptom-based Rome criteria for functional GI disorders, which was recently updated released as IV. Both physiologic psychological variables play role etiology perpetuate symptoms. Although research has shed light on pathophysiology, therapeutic...
Endoscopic necrosectomy for necrotizing pancreatitis has been increasingly used as an alternative to surgical or percutaneous interventions. The use of fully covered esophageal self-expandable metallic stents may provide a safer and more efficient route internal drainage. aim this study was evaluate the safety efficacy endoscopic treatment pancreatic necrosis with these stents.A retrospective at 2 US academic hospitals included patients infected from July 2009 November 2012. These underwent...
To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome (IBS).A database search for relevant was conducted using PubMed, Scopus Embase February 2015. Date filters were applied from year 2009 onward, studies limited to those written English language performed upon human subjects. The initial yielded 797 articles, out of which 38 pulled full text review 27 included study analysis. Investigations reviewed determine design,...
Many Australian children are insufficiently active to accrue health benefits and physical activity (PA) levels consistently lower among youth of low socio-economic position. PA decline dramatically during adolescence evidence suggests that competency in a range fundamental movement skills (FMS) may serve as protective factor against this trend. The Supporting Children’s Outcomes Using Rewards Exercise Skills (SCORES) intervention is multi-component FMS for primary schools low-income...
Background and study aims Fully covered self-expanding metal stents (FCSEMS) have been used to treat refractory pancreatic duct strictures. We aimed evaluate the feasibility, safety, efficacy of FCSEMS in chronic pancreatitis with Patients methods This was a retrospective multicenter cases series patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) placement main (MPD) at five tertiary care centers between February 2010 June 2016. Primary endpoints were technical...
Stress has demonstrated effects on inflammation though underlying cell-cell communication mechanisms remain unclear. We hypothesize that circulating RNAs and extracellular vesicles (EVs) in patients with chronic stress contain signals functional roles cell repair.Blood transcriptome from Irritable Bowel Syndrome versus controls were compared to identify signaling pathways effectors. Plasma EVs isolated (size-exclusion chromatography) characterized for effectors' presence (immunogold...
Irritable bowel syndrome (IBS) is a chronic, common disorder of the gastrointestinal tract associated with high psychological comorbidity and diminished quality life. Patients IBS display heightened sensitivity to stress, although literature inconsistent as whether they have dysregulated stress response. The purpose present investigation, substudy larger research effort, was examine physiological correlates perceived in patients (cortisol adrenocorticotropic hormone) explore associations...
Background: Irritable bowel syndrome (IBS) is a chronic gastrointestinal condition predominantly affecting the female sex, and characterized by brain-gut axis dysregulation. Relevance of hormones along hypothalamic-pituitary gonadal adrenal to IBS symptomatology remain unclear, as does significance other modulators including brain derived neurotrophic factor (BDNF), leptin, transforming growth βeta 1 (TGF-β1). Methods: Females with were compared healthy controls (HC) on age, race, hormonal...
Background: Psychological state, stress level, and gastrointestinal function are intricately related relevant to symptom exacerbation in patients with irritable bowel syndrome (IBS), but genetic contributors this brain–gut connection not fully understood. The purpose of exploratory study was compare gene expression participants IBS that healthy controls (HC) examine patterns by sex subtype. Method: Participants were recruited an ongoing protocol at the National Institutes Health. Differences...
Abstract Background Irritable bowel syndrome (IBS) is characterized by abdominal pain, habit alterations, and psychiatric comorbidities. Although pathophysiology remains incompletely understood, prior work demonstrates associations with brain‐derived neurotrophic factor (BDNF) catechol‐O‐methyltransferase (COMT). The purpose of this study was to quantify BDNF COMT in plasma neuronal‐enriched extracellular vesicles (nEVs), assess relationships psychological symptoms, gain insight on the...
Sex and subtype differences within patients with irritable bowel syndrome (IBS) complicate the understanding of disorder pathogenesis hinder design efficacious, therapeutic interventions.
Schimmelpenning syndrome is a rare, well-defined constellation of clinical phenotypes associated with the presence nevus sebaceous and multisystem abnormalities most commonly manifested as cerebral, ocular, skeletal defects [<xref ref-type="bibr" rid="ref1">1</xref>]. A single nucleotide mutation in HRAS or KRAS genes resulting genetic mosaicism responsible for manifestations this majority cases. We report case an adolescent boy multifocal pilocytic astrocytoma. No gene mutations were noted...
Colonic epithelial health is implicated in a host of gastrointestinal (GI) diseases and disorders. Lysozyme suspected to play role the ability epithelium recover from injury (Abey et al., press; Gallo, 2012; Rubio, 2014) [1], [2], [3]. Disrupted repair mechanisms may lead delayed or ineffective recovery disruptions biology resulting GI symptoms altered barrier function (Peterson Artis, [4]. The effect lysozyme on transcriptomic proteomic profile healthy colonic cells was investigated....
Airport departure demand that exceeds capacity can lead to longer queues than necessary. Departure metering is one approach managing the flow of aircraft queue so as build an appropriate inventory departures on surface. The Reservoir Coordinator (DRC) envisioned role will be responsible for a procedure. This paper describes functional analysis DRC and requirements supporting person or team in were derived from analysis. Results used develop display concepts evaluated by air traffic controllers.