A5078081721- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Zebrafish Biomedical Research Applications
- RNA modifications and cancer
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer-related molecular mechanisms research
- Hippo pathway signaling and YAP/TAZ
- MicroRNA in disease regulation
- Nanocluster Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- MXene and MAX Phase Materials
- 2D Materials and Applications
- Axon Guidance and Neuronal Signaling
- Vestibular and auditory disorders
- CRISPR and Genetic Engineering
- Synthesis and Properties of Aromatic Compounds
- Extracellular vesicles in disease
- Cancer Research and Treatments
- RNA Research and Splicing
- Neuroscience of respiration and sleep
- Biomarkers in Disease Mechanisms
- Graphene research and applications
- Nanomaterials for catalytic reactions
Shenzhen Second People's Hospital
2016-2025
Shenzhen University Health Science Center
2018-2024
Shenzhen University
2018-2024
Peking University
2015-2023
Guangzhou Medical University
2023
University of South China
2022-2023
Shenzhen Sixth People's Hospital
2022
The First Affiliated Hospital, Sun Yat-sen University
2021
Sun Yat-sen University
2021
Microscale (United States)
2020
As next-generation artificial enzymes, nanozymes have shown great promise for tumor catalytic therapy. In particular, their peroxidase-like activity has been employed to catalyze hydrogen peroxide (H2O2) produce highly toxic hydroxyl radicals (•OH) kill cells. However, limited by the low affinity between with H2O2 and level of in microenvironment, peroxidase usually produced insufficient •OH cells therapeutic purposes. Herein, we present a pyrite nanozyme ultrahigh affinity, resulting 4144-...
The clustered regularly interspaced short palindromic repeats (CRISPR) molecular system has emerged as a promising technology for the detection of nucleic acids. Herein, development surface plasmon resonance (SPR) sensor that is functionalized with layer locally grown graphdiyne film, achieving excellent sensing performance when coupled catalytically deactivated CRISPR-associated protein 9 (dCas9), reported. dCas9 immobilized on and complexed specific single-guide RNA, enabling...
Abstract Non‐invasive cancer photothermal therapy (PTT) is a promising replacement for traditional treatments. The second near‐infrared region induced PTT (NIR‐II PTT, 1000–1500 nm) with less energy dissipation has been developed deeper‐seated tumor treatment in recent years compared the first light (750–1000 nm). In addition, use of emerging inorganic 2D nanomaterials as agents (PTAs) further enhanced efficiency due to their intrinsic properties. NIR‐II stimulated becoming hot topic both...
Abstract Here, we describe a combination strategy of black phosphorus (BP)-based photothermal therapy together with anti-CD47 antibody (aCD47)-based immunotherapy to synergistically enhance cancer treatment. Tumour resistance immune checkpoint blockades in most cancers due escape from host surveillance, along the initiation metastasis through immunosuppressive cells tumour microenvironment, remains significant challenge for immunotherapy. aCD47, an agent CD47/SIRPα axis blockade, induces...
Photoacoustic imaging (PAI) is an attractive modality, which promising for clinical cancer diagnosis due to its advantages on deep tissue penetration and fine spatial resolution. However, few tumor catalytic/responsive PAI strategies are developed. Here, we design exosome-like nanozyme vesicle in vivo H2O2-responsive of nasopharyngeal carcinoma (NPC). The intrinsic peroxidase-like activity graphene quantum dot (GQDzyme) effectively converts the 2,2′-azino-bis...
Excessive oxidative stress in cancer cells can induce cell death. Anticancer activity and drug resistance of chemotherapy are closely related to the redox state tumor cells. Herein, five lipophilic Pt(IV) prodrugs were synthesized on basis most widely used anticancer cisplatin, whose efficacy intracellular state. Subsequently, a series cisplatin-sensitive drug-resistant lines as well three patient-derived primary ovarian have been selected screen those prodrugs. To verify if disruption...
Glioblastoma (GBM) poses a significant therapeutic challenge due to its invasive nature and limited drug penetration through the blood–brain barrier (BBB). In response, here we present an innovative biomimetic approach involving development of genetically engineered exosome nanocatalysts (Mn@Bi2Se3@RGE-Exos) for efficient GBM therapy via improving BBB enzyme-like catalytic activities. Interestingly, photothermally activatable multiple reactivity is observed in such nanosystem. Upon NIR-II...
The catalytically dead Cpf1 endonuclease from Acidaminococcus sp. BV3L6 (dAsCpf1) has been used to construct effective transcriptional repressors in bacteria and plants. However, it is still unclear if dAsCpf1 can function human cells as a regulator or signal conductor. Here, we repurpose the system for variety of functions, including activation repression gene transcription. Moreover, programmable ligand-controlled systems either by coupling crRNAs with engineered riboswitches fusing...
Abstract The impact of discontinuation anti-VEGF cancer therapy in promoting metastasis is unknown. Here we show treatment creates a time-window profound structural changes liver sinusoidal vasculatures, exhibiting hyper-permeability and enlarged open-pore sizes the fenestrated endothelium loss VE-cadherin. drug cessation caused highly leaky hepatic vasculatures permit tumour cell intravasation extravasation. Discontinuation an antibody-based sunitinib markedly promotes metastasis....
The outbreak of SARS-coronavirus 2 (SARS-CoV2) has become a global health emergency. Although enormous efforts have been made, there is still no effective treatment against the new virus. Herein, TiO2 supported single-atom nanozyme containing atomically dispersed Ag atoms (Ag-TiO2 SAN) designed to serve as highly efficient antiviral nanomaterial. Compared with traditional nano-TiO2 and Ag, Ag-TiO2 SAN exhibits higher adsorption (99.65%) SARS-CoV2 pseudovirus. This ability due interaction...
Cisplatin-related ototoxicity is a critical side effect of chemotherapy and can lead to irreversible hearing loss. This study aimed assess the potential DNA methyltransferase (DNMT) inhibitor RG108 on cisplatin-induced ototoxicity. Immunohistochemistry, apoptosis assay, auditory brainstem response (ABR) were employed determine impacts injury in murine hair cells (HCs) spiral ganglion neurons (SGNs). Rhodamine 123 TMRM utilized for mitochondrial membrane (MMP) assessment. Reactive oxygen...
Molecular signaling in the tumor microenvironment (TME) is complex, and crosstalk among various cell compartments supporting metastasis remains poorly understood. In particular, role of vascular pericytes, a critical cellular component TME, cancer invasion warrants further investigation. Here, we report that an elevation FGF-2 samples from patients with nasopharyngeal carcinoma (NPC) xenograft mouse models promoted NPC metastasis. Mechanistically, cell-derived strongly pericyte proliferation...
Abstract Single‐atom nanozymes (SANzymes) emerge as promising alternatives to conventional enzymes. However, chemical instability limits their application. Here, a systematic synthesis of highly active and stable SANzymes is presented by leveraging noble metal–porphyrins. Four metal–porphyrins are successfully synthesized mimic the site natural peroxidases through atomic metal–N coordination anchored porphyrin center. These integrated into biocompatible Zr‐based metal–organic framework (M x...