A5032819480- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Rabies epidemiology and control
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Viral Infections and Outbreaks Research
- Radiomics and Machine Learning in Medical Imaging
- Mitochondrial Function and Pathology
- interferon and immune responses
- Atherosclerosis and Cardiovascular Diseases
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- RNA Research and Splicing
- Metabolomics and Mass Spectrometry Studies
- Renal cell carcinoma treatment
- Signaling Pathways in Disease
- MicroRNA in disease regulation
- Sirtuins and Resveratrol in Medicine
- Viral Infections and Vectors
- Histone Deacetylase Inhibitors Research
- Toxoplasma gondii Research Studies
Fudan University
2012-2025
Eastern Hepatobiliary Surgery Hospital
2025
Second Military Medical University
2022-2025
Sun Yat-sen University
2019-2024
First Affiliated Hospital of Zhengzhou University
2021-2024
Ningbo Medical Center Lihuili Hospital
2024
Ningbo University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Zhongshan Hospital
2024
Wuhan University of Technology
2023
Aberrant activation of Bruton's tyrosine kinase (BTK) plays an important role in pathogenesis B-cell lymphomas, suggesting that inhibition BTK is useful the treatment hematological malignancies. The discovery a more selective on-target covalent inhibitor high value. Herein, we disclose and preclinical characterization potent, selective, irreversible as our clinical candidate by using vitro potency, selectivity, pharmacokinetics (PK), vivo pharmacodynamic for prioritizing compounds. Compound...
Loss-of-function mutations in genes encoding TET DNA dioxygenase occur frequently hematopoietic malignancy, but rarely solid tumors which instead commonly have reduced activity. The impact of decreased activity is not known. Here we show that TET2 mediates interferon γ (IFNγ)-JAK-STAT signaling pathway to control chemokine and PD-L1 expression, lymphocyte infiltration cancer immunity. IFNγ stimulated STAT1 bind recruit hydroxymethylate genes. Reduced was associated with TH1-type chemokines...
Significance PD-L1 is well known as an immune checkpoint molecule, which suppresses surveillance through binding to its receptor PD-1. Intracellular can also protect messenger RNAs of several DNA damage repair–related genes from degradation and enhance tumor resistance DNA-damaging therapy. Triple-negative breast cancer (TNBC) has the worst prognosis highest risk distant relapse in shows immunotherapy radiotherapy. In this study, we found that D-mannose promote significantly radiotherapy...
Glycolytic enzyme phosphoglycerate mutase (PGAM) plays an important role in coordinating energy production with generation of reducing power and the biosynthesis nucleotide precursors amino acids. Inhibition PGAM by small RNAi or molecule attenuates cell proliferation tumor growth. activity is commonly upregulated cells, but how regulated vivo remains poorly understood. Here we report that acetylated at lysine 100 (K100), active site residue invariably conserved from bacteria, to yeast,...
Although zinc oxide nanoparticles (ZnO NPs) have been widely used, their potential hazards on mammalian and human remain largely unknown. In this study, the biochemical compositions of urine kidney from rats treated with ZnO NPs (100, 300 1000 mg/kg, respectively) were investigated using 1H nuclear magnetic resonance (NMR) technique pattern recognition partial least squares-discriminant analysis. Hematology, clinical biochemistry histopathological examinations also performed. Metabolic...
Atrial fibrillation (AF) is one of the most prevalent sustained arrhythmias, however, epidemiological data may understate its actual prevalence. Meanwhile, AF considered to be a major cause ischemic strokes due irregular heart-rhythm, coexisting chronic vascular inflammation, and renal insufficiency, blood stasis. We studied co-expressed genes understand relationships between atrial stroke reveal potential biomarkers therapeutic targets AF-related stroke. AF-and stroke-related differentially...
Abstract Renal fibrosis induced by urinary tract obstruction is a common clinical occurrence; however, effective treatment lacking, and deeper understanding of the mechanism renal needed. Previous studies have revealed that miR‐21 impacts liver lung progression activating SPRY1/ERK/NF‐kB signalling pathway. However, whether mediates obstructive through same pathway has not been determined. Additionally, shown N6‐methyladenosine (m 6 A) modification‐dependent primary microRNA (pri‐microRNA)...
Lung cancer is one of the leading causes cancer-related death worldwide. Cytology plays an important role in initial evaluation and diagnosis patients with lung cancer. However, due to subjectivity cytopathologists region-dependent diagnostic levels, low consistency liquid-based cytological results certain proportions misdiagnoses missed diagnoses. In this study, we performed a weakly supervised deep learning method for classification benign malignant cells images through convolutional...
Molecular signaling in the tumor microenvironment (TME) is complex, and crosstalk among various cell compartments supporting metastasis remains poorly understood. In particular, role of vascular pericytes, a critical cellular component TME, cancer invasion warrants further investigation. Here, we report that an elevation FGF-2 samples from patients with nasopharyngeal carcinoma (NPC) xenograft mouse models promoted NPC metastasis. Mechanistically, cell-derived strongly pericyte proliferation...
The role of single atomic Ru site for enhanced UOR performance.
How cancer cells evade the therapeutic effects of immune checkpoint blockade is largely unknown. Here, we report that fibrinogen-like protein 1 (FGL1), a newly identified ligand, was modified by acetylation at Lys 98 in hepatocellular carcinoma (HCC), which targeted it for proteasomal degradation. Sirtuin 2 (SIRT2) deacetylated and stabilized FGL1, thus promoting evasion. Notably, SIRT2 inhibitor 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide (AGK2) enhanced FGL1...
Adipose-secreted WNT5A triggers vascular disease in obesity, activating smooth muscle cell migration by an NADPH oxidase–dependent mechanism.
Poly (ADP-ribose) polymerase (PARP) plays a significant role in DNA repair responses; therefore, this enzyme is targeted by PARP inhibitors cancer therapy. Here we have developed number of fused tetra- or pentacyclic dihydrodiazepinoindolone derivatives with excellent enzymatic and cellular PARylation inhibition activities. These efforts led to the identification pamiparib (BGB-290, 139), which displays PARP-1 PARP-2 IC50 1.3 0.9 nM, respectively. In assay, compound inhibits activity = 0.2...
Abstract Folic acid, served as dietary supplement, is closely linked to one-carbon metabolism and methionine metabolism. Previous clinical evidence indicated that folic acid supplementation displays dual effect on cancer development, promoting or suppressing tumor formation progression. However, the underlying mechanism remains be uncovered. Here, we report high-folate diet significantly promotes development in mice with hepatocellular carcinoma (HCC) induced by DEN/high-fat (HFD),...
Abstract Inactivating mutations of von Hippel–Lindau (VHL) are highly prevalent in clear cell renal carcinoma (ccRCC). Improved understanding the vulnerabilities VHL-deficient ccRCC could lead to improved treatment strategies. The activity DNA dioxygenase ten-eleven translocation (TET)2 is significantly reduced multiple cancers by different mechanisms, but its role progression remains unclear. Here, we report that increased expression TET2, not TET1 and TET3, negatively associated with tumor...