A5003150781- Cardiovascular Disease and Adiposity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Nitric Oxide and Endothelin Effects
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Sphingolipid Metabolism and Signaling
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Hormonal Regulation and Hypertension
- Lipoproteins and Cardiovascular Health
- Eicosanoids and Hypertension Pharmacology
- Coronary Interventions and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Advanced Glycation End Products research
- Cardiovascular Health and Risk Factors
- COVID-19 Clinical Research Studies
- Cardiac and Coronary Surgery Techniques
- Telomeres, Telomerase, and Senescence
- Circular RNAs in diseases
- Endoplasmic Reticulum Stress and Disease
- Cardiac Valve Diseases and Treatments
- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
University of Oxford
2015-2024
John Radcliffe Hospital
2016-2024
University of Crete
2020-2023
University Hospital of Heraklion
2013-2023
University of Birmingham
2023
King's College London
2016
Maastricht University
2016
Early detection of vascular inflammation would allow deployment targeted strategies for the prevention or treatment multiple disease states. Because is not detectable with commonly used imaging modalities, we hypothesized that phenotypic changes in perivascular adipose tissue (PVAT) induced by could be quantified using a new computerized tomography (CT) angiography methodology. We show inflamed human vessels release cytokines prevent lipid accumulation PVAT-derived preadipocytes vitro, ex...
Coronary inflammation induces dynamic changes in the balance between water and lipid content perivascular adipose tissue (PVAT), as captured by Fat Attenuation Index (FAI) standard coronary CT angiography (CCTA). However, is not only process involved atherogenesis we hypothesized that additional radiomic signatures of adverse fibrotic microvascular PVAT remodelling, may further improve cardiac risk prediction.
Adiponectin has anti-inflammatory effects in experimental models, but its role the regulation of myocardial redox state humans is unknown. Although adiponectin released from epicardial adipose tissue (EpAT), it unclear whether exerts any paracrine on human myocardium.To explore cross talk between EpAT-derived and heart.EpAT atrial myocardium were obtained 306 patients undergoing coronary artery bypass grafting. Functional genetic polymorphisms that increase ADIPOQ expression (encoding...
Abstract Aims Recent clinical trials indicate that sodium-glucose cotransporter 2 (SGLT2) inhibitors improve cardiovascular outcomes in heart failure patients, but the underlying mechanisms remain unknown. We explored direct effects of canagliflozin, an SGLT2 inhibitor with mild SGLT1 inhibitory effects, on myocardial redox signalling humans. Methods and results Study 1 included 364 patients undergoing cardiac surgery. Right atrial appendage biopsies were harvested to quantify superoxide...
Obesity is associated with increased cardiovascular risk; however, the potential role of dysregulations in adipose tissue (AT) metabolome unknown. The aim this study was to explore dysregulation AT on vascular redox signaling and outcomes. A screen conducted for metabolites differentially secreted by thoracic (ThAT) subcutaneous obese patients atherosclerosis (n = 48), these were then linked dysregulated 633 undergoing coronary bypass surgery. underlying mechanisms explored human aortic...
Adipose-secreted WNT5A triggers vascular disease in obesity, activating smooth muscle cell migration by an NADPH oxidase–dependent mechanism.
Given the clinical, economic, and societal impact of obesity, unraveling mechanisms adipose tissue expansion remains fundamental significance. We previously showed that white (WAT) levels 3-mercaptopyruvate sulfurtransferase (MPST), a mitochondrial cysteine-catabolizing enzyme yields pyruvate sulfide species, are downregulated in obesity. Here, we report Mpst deletion results fat accumulation mice fed high-fat diet (HFD) through transcriptional metabolic maladaptation. Mpst-deficient on HFD...
Experimental evidence suggests that telomere length (TL) is shortened by oxidative DNA damage, reflecting biological aging. We explore the value of blood (BTL) and vascular TL (VTL) as biomarkers systemic/vascular stress in humans test clinical predictive BTL acute myocardial infarction (AMI).In a prospective cohort 290 patients surviving recent AMI, measured on admission was strong predictor all-cause [hazard ratio (HR) [95% confidence interval (CI)]: 3.21 [1.46-7.06], P = 0.004]...
Diabetes, obesity, and Alzheimer’s disease (AD) are associated with vascular complications impaired nitric oxide (NO) production. Furthermore, increased β-site amyloid precursor protein–cleaving (APP-cleaving) enzyme 1 (BACE1), APP, β-amyloid (Aβ) linked development BACE1 Aβ accompany hyperglycemia hyperlipidemia. However, the causal relationship between obesity diabetes, Aβ, dysfunction is unclear. We report that diet-induced (DIO) in mice plasma Aβ42 correlated decreased NO...
Visceral obesity is directly linked to increased cardiovascular risk, including heart failure. This study explored the ability of human epicardial adipose tissue (EAT)-derived microRNAs (miRNAs) regulate myocardial redox state and clinical outcomes. screened for miRNAs expressed released from EAT tested correlations with in adjacent myocardium paired EAT/atrial biopsy specimens patients undergoing cardiac surgery. Three were then causality an vitro model cardiomyocytes. At a level,...
Abstract Aims Genome-wide association studies (GWAS) have consistently identified an between coronary artery disease (CAD) and a locus on chromosome 10 containing single gene, JCAD (formerly KIAA1462). However, little is known about the mechanism by which could influence development of atherosclerosis. Methods results Vascular function was quantified in subjects with CAD flow-mediated dilatation (FMD) vasorelaxation responses isolated blood vessel segments. The risk allele GWAS associated...
Vascular oxidative stress in human atherosclerosis is reversed by restoring vascular insulin sensitivity using a dipeptidyl peptidase 4 inhibitor.
Cardiovascular disease is a leading cause of morbidity and mortality. New research elucidates in-creasingly complex relationships between cardiac metabolic health, giving rise to new possible therapeutic targets. Sphingolipids are heterogenous class bioactive lipids with critical roles in normal human physiology. They have also been shown play both protective deleterious the pathogenesis cardiovascular disease. This review will explore vascular, cardiac, pathologies evaluate potential...