A5100452286- Sexual function and dysfunction studies
- Hormonal and reproductive studies
- Sexual Differentiation and Disorders
- Urinary Bladder and Prostate Research
- CAR-T cell therapy research
- Sexuality, Behavior, and Technology
- Eating Disorders and Behaviors
- Genital Health and Disease
- Hip and Femur Fractures
- Mitochondrial Function and Pathology
- Sleep and Wakefulness Research
- Gout, Hyperuricemia, Uric Acid
- Stress Responses and Cortisol
- Sleep and related disorders
- Circadian rhythm and melatonin
- Biomarkers in Disease Mechanisms
- Trauma and Emergency Care Studies
- MicroRNA in disease regulation
- Clusterin in disease pathology
- Urologic and reproductive health conditions
- Biochemical effects in animals
- Urological Disorders and Treatments
- Machine Learning and Data Classification
- Adipose Tissue and Metabolism
- Migraine and Headache Studies
Xuzhou Medical College
2025
Shandong First Medical University
2024
Shandong Provincial Hospital
2024
First Affiliated Hospital of Anhui Medical University
2021-2024
Anhui Medical University
2021-2024
Daping Hospital
2020-2024
Army Medical University
2009-2024
Anqing City Hospital
2022
Nanjing Medical University
2022
Chinese People's Liberation Army
2021
Aberrant activation of Bruton's tyrosine kinase (BTK) plays an important role in pathogenesis B-cell lymphomas, suggesting that inhibition BTK is useful the treatment hematological malignancies. The discovery a more selective on-target covalent inhibitor high value. Herein, we disclose and preclinical characterization potent, selective, irreversible as our clinical candidate by using vitro potency, selectivity, pharmacokinetics (PK), vivo pharmacodynamic for prioritizing compounds. Compound...
Motor-free visual perception abilities are important reference indicator for children's literacy skills. In the absence of Chinese norms, this study utilized motor-free test-4 (MVPT-4) to assess children aged 5–12 years in Xuzhou, China, lay foundation establishing standardized norms China. From May July 2023, a stratified random sampling method was used conduct MVPT-4 evaluation on 525 kindergarten and primary school raw scores each age group showed an increasing trend with age, differences...
Hepatic ischaemia reperfusion injury (HIRI) is a major factor leading to liver dysfunction after resection and transplantation. Adipose-derived mesenchymal stem cells (ADSCs) have potential therapeutic effects on HIRI. Exosomes derived from ADSCs (ADSCs-exo) been widely studied as an alternative of therapy. Thus, the aim this study was evaluate protective effect related mechanism ADSCs-exo HIRI subsequent hepatectomy. Rats were randomly divided into four groups: Sham, I30R+PH, group. After...
Abstract The clinical role and underlying mechanisms of valproic acid (VPA) on bone homeostasis remain controversial. Herein, we confirmed that VPA treatment was associated with decreased mass mineral density (BMD) in both patients mice. This effect attributed to VPA-induced elevation osteoclast formation activity. Through RNA-sequencing, observed a significant rise precursor miR-6359 expression VPA-treated precursors vitro, further, marked upregulation mature (miR-6359) vivo demonstrated...
Background/Aims: Ischemia-reperfusion (I/R) injury is an unavoidable event occurring during heart transplantation and a key factor in graft failure the long-term survival rate of recipients. Therefore, there urgent need for development new therapies to prevent I/R injury. Clusterin hetero-dimeric glycoprotein with antiapoptotic function. In this study, we investigated whether clusterin was cardioprotective against using vivo rat model vitro cell culture system, examined underlying mechanisms...
Purpose: We developed a nomogram to predict the possibility of lymph node metastasis in patients with squamous cell carcinoma penis. Methods: Identifying penis diagnosed between 2004 and 2015 Surveillance, Epidemiology, End Results (SEER) database. Univariate multivariate analyses were carried out by logistic regression assess significant predictors associated metastasis. A was established validated calibration plot receptor operating characteristic curve (ROC) analysis. Results: total 1,016...
The current chemotherapy regimens may extend survival for patients with metastatic bladder cancer (BCa) a few months, but eventually most succumb to disease because they develop resistance their chemotherapy. TCGA human clinical sample survey and urothelial tumor tissue microarrays (TMAs) were applied investigate the expression of androgen receptor (AR) NF-κB. Multiple BCa cell lines used test chemotherapy’s efficacy via multiple assays including XTT, flow cytometry, TUNEL, BrdU...
The degree of early brain injury (EBI) is a significant factor that affects the prognosis patients with subarachnoid hemorrhage (SAH). Evidence has shown fibroblast growth factor-2 (FGF-2) may alleviate serious consequences EBI after SAH. objective current study was to investigate underlying mechanism mediates neuroprotective effects FGF-2 in SAH rat model. Sprague-Dawley (SD) rats underwent different treatments were divided into various groups. administered intranasally treatment group...
Background:The monocyte-to-high-density lipoprotein cholesterol (MHR) ratio has been linked to metabolic disorders.However, there is limited research on the predisposition MHR and prediabetes.Hence, we conducted a study investigate relationship between prevalence of prediabetes.Methods: In total, 85,293 participants were included in our cross-sectional observational study.Multivariable regression analysis, subgroup analyses, interaction testing used determine prediabetes.To explore nonlinear...
The treatment methods for posterior wall (PW) in both-column acetabular fractures are controversial. purpose of this study was to compare reduction quality, clinical outcomes, and complications nonfixation fragment plating via the Kocher-Langenbeck (KL) approach after anterior surgical procedures fractures.Forty-nine patients with associated PW fixed iliac fossa Stoppa approaches from October 2012 2017 were recruited into divided two groups: Nonfix group (nonfixation PW) KL (PW through...