Abstract Background Testosterone deficiency (TD) and obesity are globally recognized health concerns, with a bidirectional causal relationship between them. And newly discovered indicator, the Weight-Adjusted-Waist Index (WWI), has been proposed, demonstrating superior adiposity identification capability compared to traditional body mass index (BMI) waist circumference (WC) indicators. Therefore, we present inaugural investigation into associations of WWI total testosterone levels risk TD....

Metabolic health is closely related to testosterone levels, and the cardiometabolic index (CMI) a novel metabolic evaluation metric that encompasses obesity lipid metabolism. However, there currently lack of research on relationship between CMI testosterone, which objective this study. This study utilized data from National Health Nutrition Examination Survey (NHANES) cycles 2011 2016. Only adult males who completed physical measurements, metabolism assessments, measurements were included in...

Abstract Background Stroke has emerged as an escalating public health challenge among middle-aged and older individuals in China, closely linked to glycolipid metabolic abnormalities. The Hemoglobin A1c/High-Density Lipoprotein Cholesterol (HbA1c/HDL-C) ratio, integrated marker of homeostasis, may serve a novel predictor stroke risk. Methods Our investigation utilized data from the China Health Retirement Longitudinal Study cohort (2011–2018). cases were identified based on self-reported,...

Abstract Background Erectile dysfunction (ED) is a prevalent condition with significant psychological and physiological impacts. Recently, new concept called movement-based behaviors (MBB) has been proposed, which includes four types of PA: vigorous PA (VPA), moderate-intensity (MPA), walking/cycling, muscle-strengthening activities (MSA), uses an MBB index (range 0–4) to estimate the combined effects these on health outcomes. Aim This study aims evaluate relationship between different...

Overactive bladder (OAB) and female sexual dysfunction (FSD) are both common problems in women, but the association between OAB FSD lacks a large sample study. The purpose of this cross-sectional study was to investigate FSD. Data for were obtained from 2007–2016 National Health Nutrition Examination Survey (NHANES) women aged 20–59 years. qualified with aid overactive symptom score (OABSS), which by adding nocturia urge urinary incontinence score, participants total ≥ 3 considered suffer...

Testosterone deficiency (TD) is a globally recognized health concern, closely linked to disruptions in uric acid and lipid metabolism. Recently, the high-density lipoprotein cholesterol ratio (UHR) has emerged as comprehensive index for assessing impact of inflammation metabolic disturbances on disease risk. Therefore, we intended explore association UHR with total testosterone levels risk TD among US male adults. The analysis was based data from National Health Nutrition Examination Survey...

Testosterone is a crucial hormone for male health, influencing metabolism, cardiovascular function, bone density, and cognitive abilities. Elevated non-HDL cholesterol to HDL ratio (NHHR) has been implicated in lipid metabolism disorders, which may adversely affect testosterone levels. This study investigates the association between NHHR levels adult males, utilizing data from National Health Nutrition Examination Survey (NHANES). cross-sectional analyzed 2,859 males NHANES cycles 2011-2016....

Several observational studies have reported the correlation between gut microbiota and risk of erectile dysfunction (ED). However, causal association them remained unestablished owing to intrinsic limitations, confounding factors, reverse causality. Therefore, two-sample Mendelian randomization (MR) study was performed determine effect on ED.The MR analysis utilized publicly available genome-wide (GWAS) summary-level data explore associations ED. The were extracted from MiBioGen (N =...

Abstract The C-reactive protein-triglyceride glucose index (CTI) is emerging as a novel indicator for comprehensively assessing the severity of both inflammation and insulin resistance. However, association between CTI erectile dysfunction (ED) remains largely unexplored. Participant data this study were sourced from NHANES 2001–2004, with exclusion criteria applied to those lacking information on clinical variables. was defined 0.412*Ln (CRP) + ln [T.G. (mg/dL) × FPG (mg/dL)/2]. Weighted...

Testosterone deficiency (TD) is an urgent health issue that requires attention, associated with various adverse outcomes including cardiovascular diseases (CVD) and metabolic syndrome. Remnant cholesterol (RC) has emerged as a potential biomarker for risk, but its relationship testosterone levels TD not been thoroughly investigated. This study aims to explore the association between RC in adult American males using data from National Health Nutrition Examination Survey (NHANES).

The novel serum C-reactive protein-triglyceride glucose index (CTI) has been identified as an ideal parameter that integrates inflammation and insulin resistance, which are potential mechanisms underlying depressive symptoms. Our research aimed to investigate the association between CTI cross-sectional investigation utilized data from National Health Nutrition Examination Survey conducted 2005 2010. integrated was calculated 0.412 × Ln (C-reactive protein) (mg/dL) + [triglyceride fasting...

The purpose of the study was to investigate relationship between neutrophil-to-lymphocyte ratio (NLR) and erectile dysfunction (ED) in adult American males using a large database.We adopted series statistical analyses NLR indices ED prevalence among participants 2001-2004 National Health Nutrition Examination Survey (NHANES) database R software.The included total 3012 participants, whom 570 (18.9%) presented with ED. levels were 2.13 (95% CI: 2.08,2.17) those without 2.36 2.27,2.45) After...

Abstract Background Recent studies demonstrated that chronic prostatitis (CP) is closely related to the gut microbiota (GM). Nevertheless, causal relationship between GM and CP has not been fully elucidated. Therefore, two-sample Mendelian randomization (MR) analysis was employed investigate this association. Methods The summary data of derived from a genome-wide association study (GWAS) involving 18,340 individuals in MiBioGen served as exposure, corresponding statistics for risk,...

Background Testosterone deficiency (TD) is closely associated with cardiovascular diseases (CVD). We intended to explore the association of Life’s Essential 8 (LE8), recently updated measurement health, prevalence TD among US male adults. Methods The population-based cross-sectional study selected adults aged 20 years or older from National Health and Nutrition Examination Survey (NHANES) 2011 2016. According American Heart Association definitions, LE8 score was measured on a scale 0–100,...

Benign prostatic hyperplasia (BPH) commonly impacts the quality of life in older men. However, there is lack research on relationship between dietary niacin intake and risk BPH. The purpose this study was to investigate Data from NHANES spanning 2003 2008 were utilized. BPH determined using a self-report questionnaire, while calculated based mean two distinct diet interviews. Multivariate logistic regressions performed explore association, supplemented with restricted cubic splines subgroup...

Background Erectile dysfunction (ED) is one of the most common male sexual disorders, closely associated with both inflammation and lipid dysregulation. Recently, a novel inflammation-lipid composite marker, CRP/HDL, has been proposed to integrate impact pathways on health, yet its relationship ED remains unexplored. Therefore, our study aimed investigate potential association between CRP/HDL ratio ED. Methods We utilized data from NHANES database, known for comprehensive high-quality...

Erectile dysfunction (ED) is considered the tip of iceberg for cardiovascular disease (CVD). However, there still conflicting evidence regarding their relationship. Recently, a validated tool Atherosclerotic Cardiovascular Disease (ASCVD) risk score has provided key opportunity to delve deeper into relationship between ED and CVD. Therefore, we intended assess 10-year ASCVD score.

Objectives To evaluate the efficacy of a novel approach to achieve optimal penile erection during doppler ultrasound (PDU) examination, which was oral sildenafil combined alprostadil injection.

To delve into the relationship between mean platelet volume (MPV) and semen quality in patients with varicocele.