A5101634746- Ovarian function and disorders
- Platelet Disorders and Treatments
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- Endometriosis Research and Treatment
- Hormonal and reproductive studies
- Extracellular vesicles in disease
- Atherosclerosis and Cardiovascular Diseases
- Gestational Diabetes Research and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Estrogen and related hormone effects
- Endometrial and Cervical Cancer Treatments
- Sexual Differentiation and Disorders
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Growth Hormone and Insulin-like Growth Factors
- Organ Transplantation Techniques and Outcomes
- Sperm and Testicular Function
- Galectins and Cancer Biology
- Vitamin D Research Studies
- Urinary Bladder and Prostate Research
- Sexual function and dysfunction studies
First Hospital of Jilin University
2024
Jilin University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021-2024
Chongqing Medical University
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2024
University of Oxford
2020-2024
John Radcliffe Hospital
2009-2024
Anhui Medical University
2023-2024
Second Hospital of Anhui Medical University
2024
Chinese PLA General Hospital
2014-2024
With increasing numbers of young female cancer survivors following chemotherapy, chemotherapy-induced fertility loss must be considered. Menstrual disorder and infertility are particular concern in patients. We showed that treatment with the alkylating agent cyclophosphamide (CTX) could cause severe primordial follicle growing apoptosis, resulting ovarian reserve. SPF C57BL/6 mice were treated a single dose 120 mg/kg CTX or saline as control, both sides ovaries collected three seven days...
We used mice with targeted deletion of 25-hydroxyvitamin D-1 α-hydroxylase [1α(OH)ase(-/-)] to investigate whether 1,25(OH)2D3 deficiency results in male infertility mediated by or extracellular calcium and phosphorus. Male 1α(OH)ase(-/-) their wild-type littermates fed either a normal diet rescue from weaning were mated at 6-14 wk age female on the same diet. The fertility efficiency females was analyzed, reproductive phenotypes males evaluated histopathological molecular techniques....
Abstract Purpose: Inhibition of angiogenesis represents a promising new therapeutic strategy for treating primary malignant brain tumors. Lenalidomide, potent analogue the antiangiogenic agent thalidomide, has shown significant activity in several hematologic malignancies, and therefore we chose to explore its tolerability patients with central nervous system Experimental Design: A phase I interpatient dose escalation trial lenalidomide recurrent tumors was conducted. Results: Thirty-six...
This study aimed to examine the methylation status of CYP19A1 promoter region in Chinese polycystic ovary syndrome (PCOS) patients.A case-control was designed that involved 10 PCOS patients and controls. Ovary tissues obtained from women with healthy controls were matched for body mass index age. Methylation detected by methylation-specific PCR. expression measured real-time PCR Western blotting.The level samples significantly higher than (0.698 ± 0.192 vs. 0.210 0.064, p < 0.01). A...
Objective ABO genetic polymorphisms have recently been associated with angiotensin-converting enzyme (ACE) activity and inflammation, which play a critical role in the pathogenic mechanism of ACE inhibitor-induced cough. Therefore, current study determined association enalapril-induced cough Chinese patients essential hypertension. Methods A total 450 hypertensive treated 10 mg enalapril maleate were genotyped for using PCR-direct sequencing method. Cough was recorded when bothered by...
<h3>Objectives</h3> To explore the potential dose–response relationship between manganese (Mn) exposure and cognitive function also plasma brain-derived neurotrophic factor (BDNF) levels in occupational Mn workers. <h3>Methods</h3> A total 819 workers were identified from our Mn-exposed workers, 293 control recruited same region. All exposed divided into three groups based on cumulative index. The Montreal Cognitive Assessment (MoCA) test was applied to estimate for all subjects. Plasma BDNF...
Polycystic ovary syndrome is a common endocrine disorder and major cause of anovulatory sterility in women at reproductive age. Most patients with polycystic have hyperandrogenism, caused by excess androgen synthesis. Bone morphogenetic protein 4 (BMP4) an essential regulator embryonic development organ formation, recent studies also shown that BMP4 may be involved female steroidogenesis process. However, the effect on hyperandrogenism remains unknown. Here, using mouse model we found...
Summary Lymphocytes are present in atherosclerotic lesion. We hypothesise that platelets may facilitate lymphocyte infiltration into the arterial wall. Reconstituted human blood or whole was perfused through a collagen-coated parallel-plate flow chamber at different shear rates. Adhered markedly enhanced adhesion increased deposition from 10 ± 3 cells/mm2 of platelet-depleted to 38 11 platelet-containing rate 500 s-1. Platelet-dependent inhibited by P-selectin, CD40L, and GPIIb/IIIa-blocking...
OBJECTIVE To determine the association of TRIB3 Q84R polymorphism with metabolic syndrome (MetS) and carotid atherosclerosis. RESEARCH DESIGN AND METHODS A case-control study enrolled 513 Chinese subjects in three groups: control, MetS, obese. The functional was genotyped among undergoing ultrasonography. clinical biochemical characteristics were determined. RESULTS For individuals R84 allele, odds ratio for developing MetS 2.349 (P = 0.018), abdominal obesity 2.351 0.012),...
Preclinical data have shown the potential of intraductal administration chemotherapy for breast cancer prevention. Direct translation this work has been stymied by anatomical differences between rodents (one duct per teat) and women (5-9 ductal systems breast). The objective phase I study was to show safety feasibility drugs into multiple ducts within one in awaiting mastectomy treatment invasive cancer. Thirty subjects were enrolled dose escalation conducted at a single center Beijing,...
Thymidine-based nucleoside analogue reverse transcriptase inhibitors and some protease of HIV are associated with lipoatrophy, relative central fat accumulation insulin resistance. The latter associations have not been well evaluated prospectively in adults commencing antiretroviral therapy. We studied the effects inhibitor-based regimens on body composition, sensitivity adipocytokine levels.48-week substudy a randomized, open-label, three-arm trial.Hospital community clinics.140...
Genetic variations of nuclear factor-κB (NF-κB) signalling pathway were found to be associated with inflammatory diseases and several malignancies. However, little is known about NF-κB gene polymorphisms susceptibility liver cancer. The aim this study was investigate whether genetic variants NFKB1 NFKBIA risk cancer in a Chinese population.The designed as nested case-control within two prospective cohorts (the Shanghai Women's Health Study, SWHS, 1996-2000 the Men's SMHS, 2002-2006).This...
In recent years, the association between oral health and risk of gastric cancer (GC) has gradually attracted increased interest. However, in terms GC incidence, incidence remains controversial. Periodontitis is reported to increase GC. some studies have shown that periodontitis no effect on Therefore, present study aimed assess whether there a relationship