A5100389115- Monoclonal and Polyclonal Antibodies Research
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Atherosclerosis and Cardiovascular Diseases
- Osteoarthritis Treatment and Mechanisms
- Systemic Lupus Erythematosus Research
- Neuroscience of respiration and sleep
- Periodontal Regeneration and Treatments
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Rheumatoid Arthritis Research and Therapies
- Circular RNAs in diseases
- Protease and Inhibitor Mechanisms
- Plant Reproductive Biology
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Infant Nutrition and Health
- Acute Myeloid Leukemia Research
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Radiology practices and education
- Cell Adhesion Molecules Research
- Complement system in diseases
Guangzhou Blood Center
2021-2024
Gansu Academy of Agricultural Sciences
2024
Guangdong Province Women and Children Hospital
2023-2024
Henan Tianguan Group (China)
2024
Harbin Medical University
2024
Shenzhen Second People's Hospital
2023-2024
Southern Medical University
2023
Sun Yat-sen University
2023
Guangzhou Medical University
2023
Chongqing Cancer Hospital
2023
Cancer of unknown primary (CUP) is a malignancy characterized by metastatic disease at diagnosis with an unidentified site, accounting for 3–5% all cancers. Despite significant advancements in cancer and treatment recent years, CUP management has been challenging due to its complexity heterogeneity; therefore, prognosis remains poor. This report presents three cases CUP. The first case involved 59-year-old female whose abdominal was identified be originating from cervical using 90-gene...
Atherosclerosis is the leading cause of global morbidity and mortality. Its therapy requires research in several areas, such as diagnosis early arteriosclerosis, improvement pharmacokinetics bioavailability rapamycin its therapeutic agents. Here, we used targeting peptide VHPKQHR (VHP) (or fluorescent reagent) to modify phospholipid molecules target vascular cell adhesion molecule-1 (VCAM-1) loaded ultrasmall paramagnetic iron oxide (USPIO/Fe3O4) plus (Rap) Rap/Fe3O4@VHP-Lipo...
2536 Background: PM8002 is a bispecific antibody targeting both PD-L1 and VEGF-A. We had completed dose escalation from 1mg/kg to 45mg/kg not found DLT/MTD. In Phase Ib expansion IIa studies we are evaluating the safety preliminary anti-tumor activity of as monotherapy. Here, provide an update Ib/IIa results. Methods: During dose-expansion studies, majority patients received at 20mg/kg Q2W or 30mg/kg Q3W monotherapy (recommended phase II doses). The primary endpoint was ORR with secondary...
Abstract Purpose Cerebral palsy (CP) is the most common neuromuscular disease in children, and currently, there no cure. Several studies have reported benefits of umbilical cord blood (UCB) cell treatment for CP. However, these either examined effects UCB fraction with a short experimental period or used neonatal rat models long-term study which displayed an insufficient immunological reaction clearance human stem cells. Here, we developed CP model by hypoxia-ischemic injury (HI) using...
It suggests that the poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) scaffold can be used for cartilage tissue engineering, but PHBV is short of bioactivity required regeneration. To fabricate a bioactive engineering promotes regeneration, quercetin (QUE) modified (PHBV-g-QUE) fibrous scaffolds were prepared by two-step surface modification method. The PHBV-g-QUE facilitates growth chondrocytes and maintains chondrocytic phenotype resulting from upregulation SOX9, COL II, ACAN....
Abstract Background There are emerging clinical evidence for umbilical cord blood mononuclear cells (UCBMNCs) intervention to improve preterm complications. The first critical step in cell therapy is obtain high-quality cells. This retrospective study aimed investigate the quantity and quality of UCBMNCs from very infants (VPIs) purpose autologous prevention treatment Methods Very born Guangdong Women Children Hospital January 1, 2017, December 8, 2022, whom was successfully collected...
Patients with HIV-1 immune-related thrombocytopenia have a unique antibody (Ab) against integrin GPIIIa49-66 capable of inducing oxidative platelet fragmentation via Ab activation nicotinamide adenine dinucleotide phosphate oxidase and 12-lipoxygenase releasing reactive oxygen species. Using phage display single-chain (scFv) library, we developed novel human monoclonal scFv (named A11) activated platelets. In this study, investigated the in vivo use A11. We show that A11 does not induce...
Abstract Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of cholesterol within arterial wall. Its progression can be monitored via magnetic resonance imaging (MRI). Ultrasmall Superparamagnetic Particles Iron Oxide (USPIO) (<5 nm) have been employed as T1 contrast agents for MRI applications. In this study, we synthesized USPIO with an average surface carboxylation approximately 5.28 nm and zeta potential −47.8 mV. These particles were phagocytosed...
Background: Cytogenetics at diagnosis is the most important prognostic factor for adult acute myeloid leukemia (AML), but nearly 50% of AML patients who exhibit cytogenetically normal (CN-AML) do not undergo effective risk stratification. Therefore, development potential biomarkers to further define stratification CN-AML worth exploring. Methods: Transcriptome data from 163 cases in GSE12417-GPL96 dataset and 104 patient GSE71014-GPL10558 were downloaded Gene Expression Omnibus database...
Magnetic resonance imaging (MRI) could be the ideal diagnostic modality for early rheumatoid arthritis (RA). Vascular cell adhesion molecule-1 (VCAM-1) is highly expressed in synovial locations patients with RA, which a potential target protein RA diagnosis. The peptide VHPKQHR (VHP) has high affinity to VCAM-1. To make contrast agent at an stage, we used VHP and ultrasmall paramagnetic iron oxide (USPIO) synthesize UVHP (U stands USPIO) through chemical reaction...
The purpose of this experiment was to determine if the low molecular weight heparin (LMWH) enoxaparin could extend treatment window for thrombolysis in a mouse model embolic stroke.To establish window, mice were treated with tPA 2, 3 or 4 hours after clot insertion. Results showed that only 2 hour group exhibited infarct volumes significantly smaller than untreated controls. We attempted widen by pre-treating (10 mg/kg, s.c.; n=36) 1 before embolization. A control (n=24) given saline...