A5112853480- Plant-Microbe Interactions and Immunity
- Extracellular vesicles in disease
- Plant Stress Responses and Tolerance
- Plant nutrient uptake and metabolism
- COVID-19 epidemiological studies
- Biofuel production and bioconversion
- Pain Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
- Efficiency Analysis Using DEA
- Banana Cultivation and Research
- Genetics and Neurodevelopmental Disorders
- Plant Gene Expression Analysis
- COVID-19 Pandemic Impacts
- Plant Virus Research Studies
- Plant pathogens and resistance mechanisms
- Thermal Regulation in Medicine
- Plant Disease Resistance and Genetics
- Cancer-related molecular mechanisms research
- Ion Channels and Receptors
- RNA modifications and cancer
- Hereditary Neurological Disorders
- Data-Driven Disease Surveillance
- Nerve Injury and Rehabilitation
- Advanced Clustering Algorithms Research
South China Normal University
2023-2025
Drexel University
2015-2025
Inner Mongolia University
2016-2024
Air Force Institute of Aviation Medicine Affiliated Hospital
2024
Universiti Sains Malaysia
2023-2024
PLA Information Engineering University
2023
Zhengzhou University
2021-2023
Gansu Agricultural University
2019-2022
Guangdong Academy of Agricultural Sciences
2021-2022
Ministry of Agriculture and Rural Affairs
2021-2022
Summary Macrophage-derived exosomes attenuated complete Freund's adjuvant-induced thermal hyperalgesia in mice. Exosomal microRNA signature from patients with complex regional pain syndrome suggests a potential therapeutic and biomarker utility for exosomes. Exosomes, secreted microvesicles transporting microRNAs (miRNAs), mRNAs, proteins through bodily fluids, facilitate intercellular communication elicit immune responses. contents vary, depending on the source physiological conditions of...
Menthol is one of the most commonly used chemicals in our daily life, not only because its fresh flavor and cooling feeling but also medical benefit. Previous studies have suggested that menthol produces analgesic action acute neuropathic pain through peripheral mechanisms. However, central actions mechanisms remain unclear. Here, we report has direct effects on spinal cord. decreased both ipsilateral contralateral hypersensitivity induced by complete Freund9s adjuvant a dose-dependent...
ATP can activate a variety of pathways through P2 purinoreceptors, leading to neuroprotection and pathology in the CNS. Among all P2X receptors, P2X7 receptor (P2X7R) is well-defined therapeutic target for inflammatory neuropathic pain. Activation P2X7R generate reactive oxygen species (ROS) macrophages microglia. However, role ROS P2X7R-induced pain remains unexplored. Here, we investigated downstream effects neuronal activation spinal cord. We found that induces production cord dorsal...
Banana is one of the most important fruits in world due to its status as a major food source for more than 400 million people. Fusarium oxysporum f. sp. cubense tropical race 4 (Foc TR4) causes substantial losses banana crops every year, and molecular host resistance mechanisms are currently unknown. We here performed genomewide analysis autophagy-related protein 8 (ATG8) family wild species. The genome was found contain 10 MaATG8 genes. Four MaATG8s formed gene cluster distal part...
Autophagy-related gene 6 (ATG6) plays a crucial role in plant immunity. Nonexpressor of pathogenesis-related genes1 (NPR1) acts as signaling hub However, the relationship between ATG6 and NPR1 is unclear. Here, we find that directly interacts with NPR1. overexpression significantly increased nuclear accumulation Furthermore, demonstrate increases protein levels improves its stability. Interestingly, promotes formation SINCs (SA-induced condensates)-like condensates. Additionally,...
Morphine and other synthetic opioids are widely prescribed to treat pain. Prolonged morphine exposure can paradoxically enhance pain sensitivity in humans nociceptive behavior rodents. To better understand the molecular mechanisms underlying opioid-induced hyperalgesia, we investigated changes microRNA (miRNA) composition of small extracellular vesicles (sEVs) from serum mice after a treatment paradigm that induces hyperalgesia. We observed significant differential expression 18 miRNAs sEVs...
Autophagy-related gene 6 (ATG6) plays a crucial role in plant immunity. Nonexpressor of pathogenesis-related genes 1 (NPR1) acts as signaling hub However, the relationship between ATG6 and NPR1 is unclear. Here, we find that directly interacts with NPR1. overexpression significantly increased nuclear accumulation Furthermore, demonstrate increases protein levels improves its stability. Interestingly, promotes formation SINCs (SA-induced condensates)-like condensates. Additionally,...
Nerve injury induces chronic pain and dysregulation of microRNAs in dorsal root ganglia (DRG). Several downregulated are predicted to target Mecp2. MECP2 mutations cause Rett syndrome these patients report decreased perception. We confirmed MeCP2 upregulation DRG following nerve repression by miRNAs vitro. regulates brain-derived neurotrophic factor (BDNF) downregulation Bdnf T158A mice exhibited reduced mechanical sensitivity Mecp2-null have DRG. MeCP2-mediated regulation the could...
Chronic pain often accompanies immune responses and cells are known to be involved in chronic pain. Store-operated calcium (SOC) channels calcium-selective cation play an important role the system. YM-58483, a potent SOC channel inhibitor, has been shown inhibit cytokine production from attenuate antigen-induced hypersensitivity reactions. Here, we report that YM-58483 analgesic actions produces antinociceptive effects acute prevents development of mice. Oral administration 10mg/kg or 30...
Pathological pain is a common and debilitating condition that often poorly managed. Central sensitization an important mechanism underlying pathological pain. However, candidate molecules involved in central remain unclear. Store-operated calcium channels (SOCs) mediate signals nonexcitable excitable cells. SOCs have been implicated wide variety of human pathophysiological conditions, including immunodeficiency, occlusive vascular diseases, cancer. the role CNS disorders has relatively...
Abstract To investigate the effect of evidence-based nursing (EBN) intervention on upper limb function in postoperative breast cancer patients undergoing radiotherapy. A total 126 who had received radiotherapy Union Hospital affiliated with Tongji Medical College, Huazhong University Science and Technology from September 2017 to 2018 were randomly divided into 2 groups, namely, experimental control 63 cases each group. Both groups routine followed by traditional EBN interventions,...
Background: Evidence is overwhelming for sex differences in pain, with women representing the majority of chronic pain patient population. There a need to explore novel avenues elucidate this bias development inflammatory conditions. Complex regional syndrome (CRPS) neuropathic disorder, and incidence CRPS greater than men by ~4:1. Since neurogenic inflammation key feature CRPS, dysregulation responses can be factor predisposing pain. Methods: Our studies investigating alterations...