A5083677901- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Medicinal Plants and Neuroprotection
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Drug Transport and Resistance Mechanisms
- Berberine and alkaloids research
- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Inflammasome and immune disorders
- Genomics, phytochemicals, and oxidative stress
- Inflammatory Bowel Disease
- Immune cells in cancer
- Bioactive Compounds and Antitumor Agents
- Ginger and Zingiberaceae research
- Cytokine Signaling Pathways and Interactions
- Plant-derived Lignans Synthesis and Bioactivity
- Phytochemistry and Bioactivity Studies
- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- Morinda citrifolia extract uses
- Autophagy in Disease and Therapy
- Phytochemistry and Bioactive Compounds
- Angiogenesis and VEGF in Cancer
Fudan University
2025
Fujian Medical University
2024-2025
Shanghai Eighth People Hospital
2025
Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2025
China Pharmaceutical University
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Xinjiang University
2023
Zhongnan University of Economics and Law
2023
First People's Hospital of Nanning
2023
Harbin Medical University
2022
Recombinant adenoviruses containing the canine factor IX (FIX) cDNA were directly introduced in hind leg muscle of mice. We show that (i) nude mice, high expression (1-5 micrograms/ml plasma) FIX protein can be detected for > 300 days; (ii) contrast, was transient (7-10 days) normal mice; (iii) CD8+ lymphocytes could within 3 days infected tissue; (iv) use beta 2-microglobulin and immunoglobulin M heavy chain "knockout" mice showed lack sustained is due to cell-mediated humoral immune...
Norisoboldine (NOR), a natural aryl hydrocarbon receptor (AhR) agonist, has been demonstrated to attenuate ulcerative colitis (UC) and induce the generation of Treg cells. Under UC condition, hypoxia widely exists in colonic mucosa, secondary changes microRNAs (miRs) expressions glycolysis contribute differentiation. At present, we worked for exploring deep mechanisms NOR-promoted differentiation its subsequent anti-UC action from angle AhR/miR or AhR/glycolysis axis. Results showed that NOR...
Abstract The imbalance between Th17 and Treg cells substantially contributes to the intestinal immune disturbance subsequent tissue injury in ulcerative colitis. triterpenoid-rich fraction of Centella asiatica was able ameliorate dextran sulfate sodium-induced colitis mice. Here we explored its active ingredient underlying mechanism with a focus on restoring Th17/Treg balance. four main triterpenoids occurring C. were shown attenuate mice by oral administration. most effective madecassoside...
Peroxisome proliferator-activated receptor gamma (PPARγ) is an enhancer of Treg responses, but the mechanisms remain elusive. This study aimed to solve this problem in view cellular metabolism.Three recognized PPARγ agonists (synthetic agonist: rosiglitazone; endogenous ligand: 15d-PGJ2; natural product: morin) were used as tools activate PPARγ. The fatty acid oxidation (FAO) was evaluated through detection uptake, oxygen consumption rate, mitochondrial mass, membrane potential and...
Alpinetin, a flavonoid compound extracted from the seeds of Alpinia katsumadai Hayata, has been demonstrated to exert massive biological properties. This study aimed evaluate effect alpinetin on dextran sulfate sodium (DSS)-induced colitis, and elucidate potential mechanisms. Alpinetin significantly alleviated colitis in mice, accompanied with restored Th17/Treg balance colons. In vitro, directly promoted Treg differentiation but exerted little Th17 differentiation, action was an aryl...
The present study determined the anti-inflammatory activity and related mechanisms of scopoletin. It was found that scopoletin significantly inhibited croton oil-induced mouse ear edema. Scopoletin could also decrease vascular dye leakage induced by topical application oil, consistent with reduced myeloperoxidase (MPO) polymorphonuclear (PMN) infiltration. inhibitor nitric oxide (NO) synthase l-Nω -nitro-arginine (l-NN, 10 mg/kg) attenuated edema 56.5%. However, pretreatment l-NN did not...
Norisoboldine (NOR) is the main alkaloid constituent in dry root of Lindera aggregata (Sims) Kosterm. (L. strychnifolia Vill.). As reported previously, orally administered NOR displayed a robust inhibition joint bone destruction present both mouse collagen-induced arthritis and rat adjuvant-induced with lower efficacious doses than that required for ameliorating systemic inflammation. This attracted us to assess effects on differentiation function osteoclasts, primary effector cells...
Although several estrogen receptor β (ERβ) agonists have been reported to alleviate IBD, the pivotal mechanism remains obscure. To examine effects and mechanisms of ERβ activation on cytokine/chemokine networks in colitis mice. Dextran sulfate sodium salt (DSS) trinitro-benzene-sulfonic acid (TNBS) were used induce mouse model. Multiple molecular biological methods employed evaluate severity level cytokine and/or chemokine. Bioinformatics analysis, ELISA immunofluorescence results showed...
Abstract Clear cell renal carcinoma (ccRCC) is the most lethal subtype of cancer, and its treatment options remain limited. Therefore, there an urgent need to discover therapeutic agents for ccRCC treatment. Here, we demonstrate that dimethyl fumarate (DMF), approved medication multiple sclerosis [1] psoriasis, can inhibit proliferation cells. Mechanistically, hepatocyte nuclear factor 1β (HNF1B), a transcription highly expressed in ccRCC, succinated by DMF at cysteine residues, leading...
Although previous studies have demonstrated allostatic load (AL) predicts depressive symptoms, few considered the association between AL and trajectories of symptoms. This study aims to systematically examine associations abnormal blood biomarkers in three biological systems with A total 6251 participants aged 45+ from China Health Retirement Longitudinal Study (CHARLS). Depressive symptoms were assessed using 10-item Center for Epidemiological Studies Depression Scale (CESD-10) five visits...
Hospital and community-acquired infections caused by Methicillin-resistant Staphylococcus aureus (MRSA) have emerged as a significant public health challenge, highlighting the urgent need for novel antibiotics. In response, antibacterial properties of natural products derived from traditional plants are being investigated potential treatments multidrug resistance. This study demonstrates potent antibacterialimoact Berberine (BBR), compound Chinese medicine, against community-associated MRSA...