A5101503734- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Genomics, phytochemicals, and oxidative stress
- Dermatologic Treatments and Research
- Circular RNAs in diseases
- Wound Healing and Treatments
- Wnt/β-catenin signaling in development and cancer
- Plant-derived Lignans Synthesis and Bioactivity
- Genital Health and Disease
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Endometrial and Cervical Cancer Treatments
- Galectins and Cancer Biology
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Sirtuins and Resveratrol in Medicine
China Pharmaceutical University
2013-2025
Chengdu Sport University
2025
Sichuan University
2018-2025
Southwest Hospital
2016-2022
Army Medical University
2016-2022
China Medical University
2002-2021
Zhejiang Chinese Medical University
2021
First Hospital of Jilin University
2021
Jilin University
2021
First Hospital of China Medical University
2000-2020
Keloids are fibroproliferative disorders characterized by exuberant extracellular matrix deposition and transforming growth factor (TGF)-β/Smad pathway plays a pivotal role in keloid pathogenesis.Centella asiatica extract has been applied scar management for ages.As one of its major components, asiatic acid (AA) recently reported to inhibit liver fibrosis blocking TGF-β/Smad pathway.However, effect on remains unknown.In order investigate the effects AA cell proliferation, invasion collagen...
Carnosine (β-alanyl-L-histidine), described as an enigmatic peptide for its antioxidant, anti-aging and especially antiproliferation properties, has been demonstrated to play anti-tumorigenic role in certain types of cancer. However, function human gastric carcinoma remains unclear. In this study, the effect carnosine on cell proliferation underlying mechanisms were investigated cultured cells. The mTOR signaling axis molecules analyzed treated results showed that treatment with led...
Ovarian cancer stem cells ( OCSC s) are sources of tumor chemoresistance and recurrence. A hypoxic microenvironment contributes to the CSC s), but underlying mechanism is not fully understood yet. Here, we show that increased HIF ‐2α expression associated with enhanced stemness s poor outcomes in ovarian patients. OVCAR ‐3 CAOV sphere‐forming S S) ‐like properties showed strong resistance adriamycin ADR ). Hypoxia (1% O 2 ) induced high both ‐1α especially ‐2α, . Notably, treatment further...
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Abstract Allergic diseases with high recurrence rates have severely threatened human health around the world. Several strategies been developed including administration of allergens or neutralizing antibodies, while allergen‐specific immunotherapy (AIT) has considered as a cure for allergic diseases. However, AIT some drawbacks anaphylactic side effects native allergen protein during therapy, poor biodistribution in targeted organs/cells, and unsatisfactory desensitization long‐term...
MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are associated with variety human cancers. Currently, little data available regarding miRNA expression in vulvar squamous cell carcinoma (VSCC); the mechanism action miRNAs VSCC still requires investigation. The aim present study was to investigate profile using miRCURY™ LNA array. levels selected were quantified by RT-qPCR. relationship between miR-590-5p and clinical pathology assessed. crucial transforming growth factor-β...
Concurrent radio chemotherapy treatment prolongs the survival rate of patients with advanced cervical cancer; however, it has adverse side‑effects. β‑elemene, an active component traditional Chinese medicinal herb Curcuma zedoaria, is a promising alternative therapeutic drug for cancer. The aim present study was to investigate antitumor effects β‑elemene in human cancer SiHa cells and determine its underlying molecular mechanisms. Cell viability, cell cycle progression apoptosis were...
Abstract Tetrandrine, a bisbenzylisoquinoline alkaloid constituent of the root Stephania tetrandra S. Moore, was previously shown to suppress differentiation T helper 17 (Th17) cells and consequently ameliorate collagen‐induced arthritis (CIA) in mice by activating aryl hydrocarbon receptor (AhR), but its underlying mechanism is incompletely understood. Here, we investigated how tetrandrine suppressed Th17 cell through AhR pathway. The naïve CD4 + were stimulated with anti‐CD3/CD28 for 72...
Abstract Higher expression of growth differentiation factor‐9 (GDF‐9) in keloids compared with hypertrophic scars and normal skin tissues has been reported recently. The present study was performed to investigate the role GDF‐9 keloid pathogenesis, elucidate its implication for asiaticoside management. data showed that could enhance proliferation, migration, invasion fibroblasts (KFs), while it only slightly elevated collagen expression, indicating effect opposite TGF‐β1. bioactivity...