A5101912854- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Malaria Research and Control
- Mosquito-borne diseases and control
- IL-33, ST2, and ILC Pathways
- Catalytic Processes in Materials Science
- Catalysis and Oxidation Reactions
- Cancer Cells and Metastasis
- Genomics and Chromatin Dynamics
- Invertebrate Immune Response Mechanisms
- Eosinophilic Esophagitis
- vaccines and immunoinformatics approaches
- Pluripotent Stem Cells Research
- RNA Research and Splicing
- interferon and immune responses
- CRISPR and Genetic Engineering
- Tuberculosis Research and Epidemiology
- Gastrointestinal motility and disorders
- Cancer-related gene regulation
- Mycobacterium research and diagnosis
- Advanced Photocatalysis Techniques
Institute of Biophysics
2014-2025
Chinese Academy of Sciences
2015-2025
Xiamen University
2023-2024
University of Science and Technology Beijing
2021-2023
Infectious Disease Research Institute
2017-2023
Jiangsu University
2019-2022
Nanjing Normal University
2022
Seattle Children's Hospital
2021-2022
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017-2022
Chongqing Medical University
2017-2022
Head and neck squamous cell carcinoma (HNSCC) is a frequently fatal heterogeneous disease. Beyond the role of human papilloma virus (HPV), no validated molecular characterization disease has been established. Using an integrated genomic analysis validation methodology we confirm four classes HNSCC (basal, mesenchymal, atypical, classical) consistent with signatures established for lung, including deregulation KEAP1/NFE2L2 oxidative stress pathway, differential utilization lineage markers...
Abstract Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and heterogeneity hepatocellular carcinoma (HCC). However, biology hepatic CSCs remains largely undefined. Through analysis transcriptome microarray data, we identify a long noncoding RNA (lncRNA) called lncBRM , which is highly expressed in liver HCC tumours. LncBRM required for self-renewal maintenance tumour initiation. In CSCs, associates with BRM initiate BRG1/BRM switch BRG1-embedded BAF complex...
Accumulating evidence suggests that cancer-associated mesenchymal stem cells (MSC) contribute to the development and metastasis of hepatocellular carcinoma (HCC). Aberrant expression long noncoding RNAs (lncRNA) has been associated with these processes but cellular mechanisms are obscure. In this study, we report HCC-associated (HCC-MSC) promote epithelial-mesenchymal transition (EMT) liver tumorigenesis. We identified a novel lncRNA termed lncRNA-MUF (MSC-upregulated factor) is highly...
Abstract Natural killer (NK) cells exert a crucial role in early immune responses as major innate effector component. However, the underlying mechanisms of NK cell development remain largely elusive. Here we show that robust autophagy appears stage immature (iNKs), which is required for development. Autophagy defects result damaged mitochondria and accumulation reactive oxygen species (ROS) leads to apoptosis cells. protects viability during through removal intracellular ROS. Phosphorylated...
Biomarkers for tuberculosis treatment outcome will assist in guiding individualized and evaluation of new therapies. To identify candidate biomarkers, RNA sequencing whole blood from a well-characterized TB cohort was performed. Application validated transcriptional correlate risk revealed symmetry host gene expression during progression latent infection to active disease resolution treatment, including return control levels after drug therapy. The also seen signature, constructed the...
Background The Cancer Genome Atlas (TCGA) Network recently comprehensively catalogued the molecular aberrations in 487 high-grade serous ovarian cancers, with much remaining to be elucidated regarding microRNAs (miRNAs). Here, using TCGA data, we surveyed miRNAs, context of their predicted gene targets. Methods and Results Integration miRNA patterns yielded evidence that proximal pairs miRNAs are processed from polycistronic primary transcripts, intronic host mRNAs derive common transcripts....