A5072933321- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- IL-33, ST2, and ILC Pathways
- Single-cell and spatial transcriptomics
- Phagocytosis and Immune Regulation
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Covalent Organic Framework Applications
- Pancreatic function and diabetes
- Advanced Photocatalysis Techniques
- Circular RNAs in diseases
- Diabetes and associated disorders
- Drug Solubulity and Delivery Systems
- Tryptophan and brain disorders
- Pluripotent Stem Cells Research
- Mosquito-borne diseases and control
- interferon and immune responses
- Cancer Immunotherapy and Biomarkers
- Eosinophilic Esophagitis
- Biosensors and Analytical Detection
- MicroRNA in disease regulation
- Mechanical Failure Analysis and Simulation
Institute of Hematology & Blood Diseases Hospital
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Jilin University
2024-2025
Jilin Medical University
2025
Cornell University
2015-2024
Shanxi Agricultural University
2022-2024
Shenyang Agricultural University
2021-2024
Genomic Health (United States)
2023-2024
Weill Cornell Medicine
2020-2024
Chinese Academy of Sciences
2014-2022
Increasing evidence suggests that cardiac arrhythmias are frequent clinical features of coronavirus disease 2019 (COVID-19). Sinus node damage may lead to bradycardia. However, it is challenging explore human sinoatrial (SAN) pathophysiology due difficulty in isolating and culturing SAN cells. Embryonic stem cells (ESCs) can be a source derive SAN-like pacemaker for modeling.
COVID-19 patients commonly present with signs of central nervous system and/or peripheral dysfunction. Here, we show that midbrain dopamine (DA) neurons derived from human pluripotent stem cells (hPSCs) are selectively susceptible and permissive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. SARS-CoV-2 infection DA triggers an inflammatory cellular senescence response. High-throughput screening in hPSC-derived identified several FDA-approved drugs can rescue the...
Summary Paragraph The SARS-CoV-2 virus has caused already over 3.5 million COVID-19 cases and 250,000 deaths globally. There is an urgent need to create novel models study using human disease-relevant cells understand key features of biology facilitate drug screening. As primary infection respiratory-based, we developed a lung organoid model pluripotent stem (hPSCs) that could be adapted for screens. organoids, particularly aveolar type II cells, express ACE2 are permissive infection....
ABSTRACT Organoid technology, as a revolutionary biomedical tool, has shown immense potential in haematological research recent years. By using three‐dimensional (3D) cell culture systems constructed from pluripotent stem cells (PSCs) or adult (ASCs), organoids can highly mimic the characteristics of vivo organs, thereby offering significant for investigating human organ development, disease processes and treatment strategies. This review introduces development focuses on their progress...
Group 3 innate lymphoid cells (ILC3) are an important regulator for immunity, inflammation and tissue homeostasis in the intestine, but how ILC3 activation is regulated remains elusive. Here we identify a new circular RNA (circRNA) circKcnt2 that induced ILC3s during intestinal inflammation. Deletion of causes gut severe colitis mice. Mechanistically, circKcnt2, as nuclear circRNA, recruits nucleosome remodeling deacetylase (NuRD) complex onto Batf promoter to inhibit expression; this turn...
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Heart injury has been reported in up to 20% of COVID-19 patients, yet the cause myocardial histopathology remains unknown. Here, using an established vivo hamster model, we demonstrate that SARS-CoV-2 can be detected cardiomyocytes infected animals. Furthermore, found damaged hamsters and autopsy samples. To explore mechanism, show both human pluripotent stem cell-derived (hPSC-derived CMs) adult (CMs) productively by SARS-CoV-2, leading secretion monocyte chemoattractant cytokine CCL2...
There is a paucity of human models to study immune-mediated host damage. Here, we utilized the GeoMx spatial multi-omics platform analyze immune cell changes in COVID-19 pancreatic autopsy samples, revealing an accumulation proinflammatory macrophages. Single-cell RNA sequencing (scRNA-seq) analysis islets exposed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or coxsackievirus B4 (CVB4) viruses identified activation macrophages and β pyroptosis. To distinguish viral versus...
Abstract Temporal and spatial-specific regulation of pluripotency networks is largely dependent on the precise modifications core transcription factors. Misregulation glutamylation implicated in severe physiological abnormalities. However, how regulates cell reprogramming remains elusive. Here we show that cytosolic carboxypeptidases 1 (CCP1) or CCP6 deficiency substantially promotes induced pluripotent (iPSC) induction embryonic stem cells (ESCs). Klf4 polyglutamylation at Glu381 by tubulin...
COVID-19 patients commonly present with neurological signs of central nervous system (CNS)1-3 and/or peripheral dysfunction4. However, which neural cells are permissive to infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been controversial. Here, we show that midbrain dopamine (DA) neurons derived from human pluripotent stem (hPSCs) selectively SARS-CoV-2 both in vitro and upon transplantation vivo, triggers a DA neuron inflammatory cellular senescence response....
Hydrogen peroxide (H2O2) is an important green chemical and a potential energy carrier. Artificial photosynthesis of H2O2 from only H2O O2 under sunlight fascinating sustainable tactic. However, deficient proton sources come the kinetically sluggish oxidation process (~s) seriously impede half‐reaction reduction (μs~ms), leading to inferior photocatalytic efficiency. Herein, we prepare benzotrifuran‐based covalent organic framework featuring electron donor‐acceptor character with hydrazone...
Hydrogen peroxide (H2O2) is an important green chemical and a potential energy carrier. Artificial photosynthesis of H2O2 from only H2O O2 under sunlight fascinating sustainable tactic. However, deficient proton sources come the kinetically sluggish oxidation process (~s) seriously impede half-reaction reduction (μs~ms), leading to inferior photocatalytic efficiency. Herein, we prepare benzotrifuran-based covalent organic framework featuring electron donor-acceptor character with hydrazone...
Lymphoid lineage commitment is an important process in haematopoiesis, which forms the immune system to protect host from pathogen invasion. However, how multipotent progenitors (MPP) switch into common lymphoid (CLP) or myeloid (CMP) during this remains elusive. Here we show that PCI domain-containing protein 2 (Pcid2) highly expressed MPPs. Pcid2 deletion haematopoietic causes skewed specification. In MPPs, interacts with Zinc finger HIT-type containing 1 (ZNHIT1) block Snf2-related CREBBP...
Abstract To interfere with the biology of SARS-CoV-2, virus responsible for COVID-19 pandemic, we focused on restoring transcriptional response induced by infection. Utilizing expression patterns SARS-CoV-2-infected cells, identified a region in gene space that was unique to infection and inversely proportional footprint known compounds characterized Library Integrated Network-based Cellular Signatures. Here demonstrate successful identification display efficacy blocking SARS-CoV-2...
Photoactive conjugated microporous polymers (CMPs) as heterogeneous photocatalysts provide a sustainable alternative to classical metal-based semiconductor photosensitizers. However, previously reported CMPs are typically synthesized through metal catalyzed coupling reactions, which bears product separation, but also increases the price of materials. Herein, new type sp