A5100399590- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- Viral gastroenteritis research and epidemiology
- HIV Research and Treatment
- CRISPR and Genetic Engineering
- Bacillus and Francisella bacterial research
- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- HIV/AIDS drug development and treatment
- Monoclonal and Polyclonal Antibodies Research
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Virus-based gene therapy research
- Plant and animal studies
- Genomics and Phylogenetic Studies
- Peanut Plant Research Studies
- Bacteriophages and microbial interactions
- Long-Term Effects of COVID-19
- Phytochemistry and Biological Activities
- Enzyme Production and Characterization
- vaccines and immunoinformatics approaches
- Herpesvirus Infections and Treatments
- Influenza Virus Research Studies
Pudong Medical Center
2023-2025
Fudan University
2013-2025
Zhejiang University
2023-2025
Shandong Academy of Forestry
2025
Aaron Diamond AIDS Research Center
2016-2024
Columbia University
2020-2024
Harbin Medical University
2023-2024
China Tobacco
2023-2024
Sun Yat-sen Memorial Hospital
2024
Sun Yat-sen University
2024
A common landmark of activated genes is the presence trimethylation on lysine 4 histone H3 (H3K4) at promoter regions. Set1/COMPASS was founding member and only H3K4 methylase in Saccharomyces cerevisiae; however, mammals, least six methylases, Set1A Set1B MLL1 to MLL4, are found COMPASS-like complexes capable methylating H3K4. To gain further insight into different roles functional targets for we have undertaken a genome-wide analysis methylation patterns wild-type Mll1(+/+) Mll1(-)(/)(-)...
The COVID-19 pandemic has ravaged the globe, and its causative agent, SARS-CoV-2, continues to rage. Prospects of ending this rest on development effective interventions. Single combination monoclonal antibody (mAb) therapeutics have received emergency use authorization 1–3 , with more in pipeline 4–7 . Furthermore, multiple vaccine constructs shown promise 8 including two ~95% protective efficacy against 9,10 However, these interventions were directed toward initial SARS-CoV-2 that emerged...
Abstract Since the start of COVID-19 pandemic, SARS-CoV-2 has caused millions deaths worldwide. Although a number vaccines have been deployed, continual evolution receptor-binding domain (RBD) virus challenged their efficacy. In particular, emerging variants B.1.1.7, B.1.351 and P.1 (first detected in UK, South Africa Brazil, respectively) compromised efficacy sera from patients who recovered immunotherapies that received emergency use authorization 1–3 . One potential alternative to avert...
Abstract The Covid-19 pandemic has ravaged the globe, and its causative agent, SARS-CoV-2, continues to rage. Prospects of ending this rest on development effective interventions. Two monoclonal antibody (mAb) therapeutics have received emergency use authorization, more are in pipeline. Furthermore, multiple vaccine constructs shown promise, including two with ~95% protective efficacy against Covid-19. However, these interventions were directed toward initial SARS-CoV-2 that emerged 2019....
Recent months have seen surges of SARS-CoV-2 infection across the globe with considerable viral evolution 1-3 . Extensive mutations in spike protein may threaten efficacy vaccines and therapeutic monoclonal antibodies 4 Two signature concern are E484K, which plays a crucial role loss neutralizing activity antibodies, N501Y, driver rapid worldwide transmission B.1.1.7 lineage. Here, we report emergence variant lineage B.1.526 that contains E484K its alarming rise to dominance New York City...
SUMMARY The relative resistance of SARS-CoV-2 variants B.1.1.7 and B.1.351 to antibody neutralization has been described recently. We now report that another emergent variant from Brazil, P.1, is not only refractory multiple neutralizing monoclonal antibodies, but also more resistant by convalescent plasma (3.4 fold) vaccinee sera (3.8-4.8 fold). cryo-electron microscopy structure a soluble prefusion-stabilized spike reveals the P.1 trimer adopt exclusively conformation in which one...
The massive and rapid transmission of SARS-CoV-2 has led to the emergence several viral variants concern (VOCs), with most recent one, B.1.1.529 (Omicron), which accumulated a large number spike mutations, raising specter that this newly identified variant may escape from currently available vaccines therapeutic antibodies. Using VSV-based pseudovirus, we found Omicron is markedly resistant neutralization sera convalescents or individuals vaccinated by two doses inactivated whole-virion...
Abstract SARS-CoV-2 infections have surged across the globe in recent months, concomitant with considerable viral evolution 1–3 . Extensive mutations spike protein may threaten efficacy of vaccines and therapeutic monoclonal antibodies 4 Two signature concern are E484K, which has a crucial role loss neutralizing activity antibodies, N501Y, driver rapid worldwide transmission B.1.1.7 lineage. Here we report emergence variant lineage B.1.526 (also known as Iota 5 ), contains its rise to...
COVID-19 patients commonly present with signs of central nervous system and/or peripheral dysfunction. Here, we show that midbrain dopamine (DA) neurons derived from human pluripotent stem cells (hPSCs) are selectively susceptible and permissive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. SARS-CoV-2 infection DA triggers an inflammatory cellular senescence response. High-throughput screening in hPSC-derived identified several FDA-approved drugs can rescue the...
HIV-infected individuals currently cannot be completely cured because existing antiviral therapy regimens do not address HIV provirus DNA, flanked by long terminal repeats (LTRs), already integrated into host genome. Here, we present a possible alternative therapeutic approach to specifically and directly mediate deletion of the full-length from infected latently human T cell genomes using specially designed zinc-finger nucleases (ZFNs) target sequence within LTR that is well conserved...
Background and Purpose— Accumulating evidence indicates that inflammatory responses cause secondary injury after intracerebral hemorrhage (ICH). We recently demonstrated the involvement of toll-like receptor 4 (TLR4) signaling in these processes. The purpose current study was to investigate protective effect mechanism TAK-242 (Ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1 -carboxylate, Takeda), a TLR4 antagonist, an ICH mouse model. Methods— intraperitoneally injected...