A5101784339- Hepatocellular Carcinoma Treatment and Prognosis
- SARS-CoV-2 and COVID-19 Research
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Cancer, Lipids, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Infection Control and Ventilation
- Cytomegalovirus and herpesvirus research
- DNA Repair Mechanisms
- Cancer Mechanisms and Therapy
- MRI in cancer diagnosis
- Hepatitis B Virus Studies
- Protein Tyrosine Phosphatases
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- vaccines and immunoinformatics approaches
- Angiogenesis and VEGF in Cancer
- Animal Virus Infections Studies
- RNA modifications and cancer
Third Affiliated Hospital of Sun Yat-sen University
2016-2024
Sun Yat-sen University
2016-2024
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2017-2024
National Institutes of Health
2021-2024
National Institute of Allergy and Infectious Diseases
2024
Georgia State University
2024
East China University of Science and Technology
2023
Kyoto University
2014-2020
Hubei University of Chinese Medicine
2014
Nanjing University
2009-2011
Here we report on the antibody and memory B cell responses of a cohort 20 volunteers who received Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) vaccine against SARS-CoV-21-4. Eight weeks after second injection vaccine, showed high levels IgM IgG anti-SARS-CoV-2 spike protein (S) receptor-binding-domain (RBD) binding titre. Moreover, plasma neutralizing activity relative numbers RBD-specific cells vaccinated were equivalent to those individuals had recovered from natural infection5,6....
Abstract Since the start of COVID-19 pandemic, SARS-CoV-2 has caused millions deaths worldwide. Although a number vaccines have been deployed, continual evolution receptor-binding domain (RBD) virus challenged their efficacy. In particular, emerging variants B.1.1.7, B.1.351 and P.1 (first detected in UK, South Africa Brazil, respectively) compromised efficacy sera from patients who recovered immunotherapies that received emergency use authorization 1–3 . One potential alternative to avert...
To date severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected over 100 million individuals resulting in two deaths. Many vaccines are being deployed to prevent coronavirus disease 2019 (COVID-19) including novel mRNA-based 1,2 . These elicit neutralizing antibodies and appear be safe effective, but the precise nature of elicited is not known 3–6 Here we report on antibody memory B cell responses a cohort 20 volunteers who received either Moderna (mRNA-1273) or...
<h3>Importance</h3> There is insufficient evidence on the efficacy of masks in general population for prevention coronavirus disease 2019 (COVID-19) public areas. Therefore, it imperative to investigate association mandatory mask-wearing policies with behaviors associated transmission COVID-19. <h3>Objective</h3> To assess mask wearing face-touching behavior among <h3>Design, Setting, and Participants</h3> This cross-sectional study used videos recorded transportation stations, streets,...
Phosphatase of regenerating liver-3 (PRL-3) has been suggested as a potential target for anticancer drugs based on its involvement in tumor metastasis. However, little is known about small-molecule inhibitor against PRL-3. In this study, we report that curcumin, the component spice turmeric, shows antitumor effect by selectively down-regulating expression PRL-3 but not family members PRL-1 and -2 p53-independent way. Curcumin inhibited phosphorylation Src stat3 partly through...
Previous studies have demonstrated that long non-coding RNAs (lncRNAs) may play critical roles in cancer biology, including Hepatocellular carcinoma (HCC). The HOXA cluster antisense RNA2 (HOXA-AS2) lncRNA plays an important role carcinogenesis, however, the underlying of HOXA-AS2 HCC remains unknown. present study examined effects on progression HCC, and explored molecular mechanisms.Quantitative real-time PCR was used to detect expression tissues cell lines. Furthermore, silencing...
Significance Apurinic/apyrimidinic endonuclease 1 (APE1) has been shown to be a critical required for class switch recombination (CSR). Here we show that APE1’s activity, but not its redox regulation or transcriptional is important CSR. Conversely, APE1 dispensable activation-induced cytidine deaminase (AID)-induced somatic hypermutation (SHM) as well IgH/c-myc translocation. Moreover, during CSR, AID-induced S-region break formation, the processing of cleaved ends because both repair...
Broadly neutralizing antibodies are proposed as therapeutic and prophylactic agents against HIV-1, but their potency breadth less than optimal. This study describes the immunization of a llama with prefusion-stabilized HIV-1 envelope (Env) trimer, BG505 DS-SOSIP, identification improvement potent nanobodies recognizing CD4-binding site (CD4bs) vulnerability. Two vaccine-elicited CD4bs-targeting nanobodies, G36 R27, when engineered into triple tandem format IgG2a-hinge region human...
Activation-induced cytidine deaminase (AID) introduces single-strand breaks (SSBs) to initiate class switch recombination (CSR), gene conversion (GC), and somatic hypermutation (SHM). CSR is mediated by double-strand (DSBs) at donor acceptor (S) regions, followed pairing of DSB ends in two S regions their joining. Because AID mutations its C-terminal region drastically impair but retain DNA cleavage SHM activity, the likely required for step after cleavage. To test this hypothesis, we...
Phosphatase of regenerating liver 3 (PRL-3) is known to be overexpressed in many tumors, and its transcript level high the vasculature endothelial cells malignant tumor tissue. However, mechanism(s) underlying enhanced expression function remain unknown. Here, we report that vascular growth factor (VEGF) can induce PRL-3 transcription human umbilical vein (HUVEC). An analysis 5′UTR revealed initiated from two distinct sites, which results formation transcripts, PRL-3-iso1 PRL-3-iso2, but...
To clarify the effects of cylcin E1 expression on HCC tumor progression, we studied cyclin and inhibitory efficacy regorafenib sorafenib in cells, investigated a potential therapy that combines treatment with inhibition. Western blotting for caspase-3 Hoechst 33225 staining was used to measure level apoptosis-related proteins under drug treatment. Our results showed enhanced after transfection compromised apoptosis cells induced by or sorafenib. Conversely, down-regulation gene inhibition...
Since the start of coronavirus disease-2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused more than 2 million deaths worldwide. Multiple vaccines have been deployed to date, but continual evolution viral receptor-binding domain (RBD) recently challenged their efficacy. In particular, SARS-CoV-2 variants originating in U.K. (B.1.1.7), South Africa (B.1.351) and New York (B.1.526) reduced neutralization activity from convalescent sera compromised...
Immunogenic cell death (ICD) can enhance the potency of immunotherapy in cancer treatment. Nevertheless, it is ambiguous how ICD-related genes (ICDRGs) contribute to hepatocellular carcinoma (HCC).
The purpose of this study was to investigate the predictive capability neutrophil-to-apolipoprotein A1 ratio (NAR) for predicting overall survival (OS) among patients with hepatocellular carcinoma (HCC) receiving transarterial chemoembolization (TACE).We investigated clinical features 554 HCC TACE and assessed NAR's value OS 222 (the discovery cohort) 332 validation cohort). association NAR circulation lectin-type oxidized low-density lipoprotein receptor-1-positive (LOX-1+ )...
Experimental and modeling study was carried out for the reduction of single iron ore pellet in H2/CO atmosphere with considering porosity evolution heat transfer characteristics product layer, reaction unreacted layer. A mathematical model proposed validated a good match to experimental data. The results showed that both effective diffusion coefficient increased time, temperature, H2 content gas mixtures. With increase pore size presented multi-level distribution characteristics. Adding 20...
Previous studies have determined that activated hepatic stellate cells (aHSCs) promote the progression of hepatocellular carcinoma (HCC) by increasing angiogenesis in cancerous tissues. In addition, angiopoietin 1 (Ang‑1) has been reported to be involved tumor growth and metastasis via promotion angiogenesis. It remains unclear whether aHSCs Ang‑1 are HCC. A total 25 HCC tumor‑adjacent tissues, 21 normal liver tissues were used present study. Immunohistochemistry (IHC) was detect expression...
Abstract Background As the fourth leading cause of cancer-related death in world, therapeutic effect and 5-year overall survival hepatocellular carcinoma (HCC) are not optimistic. Previous researches indicated that disorder PRDXs was related to occurrence development cancers. Methods In this study, were found various tumor cell lines by CCLE database analysis. The analysis results UALCAN, HCCDB Human Protein Atlas databases showed expression mRNA protein HCC tissues dysregulated. Besides,...
Abstract Background To investigate the correlation between microinvasion and various features of hepatocellular carcinoma (HCC), to clarify distance from visible HCC lesions subclinical lesions, so as provide clinical basis for expandable boundary target volume (CTV) gross tumor (GTV) in radiotherapy HCC. Methods patients underwent hepatectomy liver cancer our hospital July 2019 November 2021 were enrolled. Data on collected. The distribution characteristics analyzed its potential with...
Angiogenesis plays a key role in the progression of hepatocellular carcinoma (HCC).This study aimed to investigate whether lipopolysaccharide (LPS) could promote HCC angiogenesis and hepatic stellate cell (HSC) this process.In vivo orthotopic model effect LPS on HSC vitro were studied.Our results demonstrated that LPS-induced activation during promotion growth mice.The LPS-TLR4 (Toll-like receptor 4) pathway is responsible for angiogenesis.LPS-induced secretion pro-angiogenic factors from...
BACKGROUND:Most forms of cancer, including hepatocellular carcinoma (HCC), are associated with varying degrees chronic inflammation. The association between the expression eicosanoids, which bioactive lipid mediators inflammation, and HCC remains unknown. aim this study was to measure serum hepatic eicosanoids in a mouse model delivery c-Met activated b-catenin by hepatocyte hydrodynamic injection. MATERIAL AND METHODS:The model, normal control mice, were used co-delivery human combined...
AIM: To study the clinical efficacy of traditional Chinese medicine (TCM) intervention "tonifying kidney to promote liver regeneration and repair by affecting stem cells their microenvironment" ("TTK") for treating failure due chronic hepatitis B. METHODS: We designed as a randomized controlled trial. Registration number Clinical Trial Registry is ChiCTR-TRC-12002961. A total 144 patients with infection B virus were enrolled in this study. Participants randomly assigned following three...