MicroRNAs play critical roles in tumorigenesis as either oncogenes or tumor suppressors. As a microRNA induced by Twist, miR-10b function metastasis driver different types of cancer, which the downstream target gene HOXD10 is main mediator. In gastric species, levels were dramatically elevated lymphoma node metastasis-positive tissues compared with metastasis-free tissues, and correlated to dowregulation expression. cell lines distinct degrees differentiation, was highly expressed line...

Abstract Background The outbreak of Corona Virus Disease (COVID-19) in 2019 has continued until now, posing a huge threat to the public’s physical and mental health, resulting different degrees health problems. As vulnerable segment public, anxiety is one most common problems among COVID-19 patients. Excessive aggravates psychological symptoms patients, which detrimental their treatment recovery, increases financial expenditure, affects family relations, adds medical burden. Objective This...

The incidence of human brucellosis has risen sharply in China but little is known about trends pastoral and agricultural areas respectively. This study aimed to analyze the annual monthly from 2004 2019. It sought identify factors contributing higher rates at specific times compare across pastoral, agricultural/pastoral, areas. Annual numbers reported cases regional between 2019 were accessed National Public Health Science Data Sharing Center, percentage change (APC) was calculated. analyzed...

Objectives. To explore effectiveness and mechanisms of electroacupuncture (EA) add-on treatment in Parkinson's disease (PD) patients. Methods. Fifty PD patients were randomly assigned to drug plus EA (D + EA) group alone (D) group. Subjects D received stimulation points bilateral fengfu, fengchi, hegu, central dazhui. Participants evaluated by scales for motor nonmotor symptoms. Levels neuroinflammatory factors neurotransmitters serum detected. Results. remarkably reduced scores Unified...

<b><i>Background:</i></b> Fatty liver disease (FLD) has become a rampant condition. It is associated with high rate of morbidity and mortality in population. The condition commonly referred as FLD. Early prediction FLD would allow patients to take necessary preventive, diagnosis, treatment. main objective this research develop machine learning (ML) model predict that can help medics classify individuals at risk FLD, make novel management, prevention for...

Abstract Objective This study aimed to explore the clinicopathological characteristics and prognostic implications of gastric neuroendocrine neoplasms (g‐NENs). Methods A retrospective enrollment 142 patients diagnosed with g‐NENs was conducted at Zhejiang Cancer Hospital between January 1, 2007 December 31, 2021. The compared essential features survival rates. Additionally, prognosis carcinomas/mixed neuroendocrine–non‐neuroendocrine (g‐NEC/MiNEN) were contrasted those adenocarcinoma (GAC)...

Human epidermal growth factor receptor 2 (H ER2) is a member of the ErbB family and key proto-oncogene in solid tumors. This pilot study investigated safety efficacy pyrotinib HER2-positive non-breast advanced Twenty-five patients with tumors excluding breast cancer were enrolled to receive pyrotinib-based therapy. The primary end point was progression-free survival (PFS). median PFS overall (OS) 3.5 months (95% CI: 2.2-5.0 months) 9.6 4.4-9.9 months), respectively. Ten lung 9 gastric had...

Background: Nurses play an important role in medical and health services insomnia symptoms were relatively high among nurses, especially during the epidemic of 2019 coronavirus disease. Insomnia not only damages physical mental individual, but also reduces efficiency their work quality care, ultimately impacting on patient care. Objective The purpose this study was to explore perceived organizational support psychological capital relationship between occupational stress Chinese nurses....

Lipid and glucose metabolism abnormalities are associated with nonalcoholic fatty liver disease (NAFLD). The triglyceride-glucose (TyG) index is a recently developed indicator that can identify individuals at risk for NAFLD. However, the applicability of TyG identifying NAFLD in patients type 2 diabetes mellitus (T2DM) unclear. aim this study was to investigate ability T2DM population.A total 2280 participants were recruited cross-sectional study. calculated, diagnosed by ultrasonography....

Background and purpose: Intravenous thrombolytic therapy significantly improves the outcomes of acute ischemic stroke patients in a time-dependent manner. The aim this study was to investigate whether continuous nursing quality improvement nurses has positive effect on reducing time thrombolysis stroke. Methods: implementation measures includes establishing full-time nurses, pre-notification by emergency medical services (EMS), team notification protocols, rapid triage, publicity education,...

Autophagy is a common phenomenon in cancer metabolism. However the mechanism and guiding significance of autophagy development gastric has remained to be elucidated. In present study, 75 tissue specimens were collected at The China Japan Union Hospital Jilin University (Changchun, China). Of these samples, 16 cases stage 1, 40 2 19 3. Polymerase chain reaction western blotting used detect messenger RNA protein expression Beclin-1, significant associated with cellular autophagy. It was found...

The purpose of this study was to investigate the predictive capability neutrophil-to-apolipoprotein A1 ratio (NAR) for predicting overall survival (OS) among patients with hepatocellular carcinoma (HCC) receiving transarterial chemoembolization (TACE).We investigated clinical features 554 HCC TACE and assessed NAR's value OS 222 (the discovery cohort) 332 validation cohort). association NAR circulation lectin-type oxidized low-density lipoprotein receptor-1-positive (LOX-1+ )...

Nurses are in high-pressure, high-load, and high-risk environment for a long time, their insomnia cannot be ignored. Insomnia not only has negative impact on the physical mental health of nurses, but also efficiency quality nursing work.

Colorectal cancer (CRC) is the third most common and fourth leading cause of mortality, twin studies have shown that approximately 35% variation in susceptibility to CRC involves inherited genetic differences. We sought investigate potential associations between some single nucleotide polymorphisms (SNPs) risk Chinese Han population.We conducted a case-control study including 269 cases 309 controls. Sixteen SNPs associated with were selected from previous genome-wide association genotyped...

Background : The efficiency of immune checkpoint inhibitors (ICIs) in bladder cancer (BLCA) treatment has been widely validated; however, the tumor response to ICIs was generally low. It is critical and urgent find biomarkers that can predict ICIs. microenvironment (TME), which may play important roles either dampen or enhance responses, concerned. Methods genome atlas BLCA (TCGA-BLCA) cohort ( n = 400) used this study. Based on proportions 22 types cells calculated by CIBERSORT, TME...

Deep vein thrombosis (DVT) is common among patients with stroke. However, the incidence of DVT in acute ischemic stroke treated thrombolytic therapy and risk factors associated this condition are unknown.This study aimed to investigate after thrombolysis stroke.We retrospectively reviewed medical records all who underwent ultrasonic examination intravenous between April 2017 December 2019 at center First Hospital Jilin University, China. Color duplex ultrasound was used diagnosis within 72 h...

Some common modified vascular risk factors remain poorly controlled among stroke survivors, and educational programs may help improve these conditions.

Background—From 2017, the Stroke Health Manager Training Project was carried out by Chinese Government to strengthen health management and follow-up intervention after ischemic stroke. The aim of this study investigate whether stroke manager, control blood pressure, low-density lipoprotein cholesterol (LDL-C), glucose level, use secondary prevention medications improved three months discharge from our center following Methods—The used a history-controlled approach. Patients who received...