Herein, we report on a two-dimensional amino-functionalized Ti3C2-MXene (N-Ti3C2-MXene)-based surface plasmon resonance (SPR) biosensor for detecting carcinoembryonic antigen (CEA) utilizing sandwich format signal amplification strategy. Our employs an N-Ti3C2-MXene nanosheet-modified sensing platform and enhancer comprising N-Ti3C2-MXene-hollow gold nanoparticles (HGNPs)-staphylococcal protein A (SPA) complexes. Ultrathin nanosheets were synthesized functionalized with aminosilane to...

Liver fibrosis results from a sustained wound healing response to chronic liver injury, and the activation of nonparenchymal hepatic stellate cells (HSCs) is pivotal process. MicroRNA-34a (miR-34a) direct target gene p53 activates through sirtuin 1 (SIRT1) simultaneously. The miR-34a/SIRT1/p53 signaling pathway thus forms positive feedback loop wherein induces miR-34a by inhibiting SIRT1, playing an important role in cell proliferation apoptosis. expression has been found be increased animal...

MicroRNAs (miRNAs) are a class of small noncoding RNAs that negatively regulate protein expression by binding protein-coding mRNAs and repressing translation. Accumulating evidence suggests miRNAs involved in cancer development progression, acting as either tumor suppressors or oncogenes. Intriguingly, it has been shown miR-133b was significantly downregulated several types cancers. However, its role relevance gastric still largely unknown. We showed human tissues cell lines compared with...

Extensive use of substances derived from natural sources has been documented in the treatment colorectal cancer (CRC). Lysionotin (Lys) is a flavonoid present flowers and leaves Gesneriaceae family plants. Despite its various pharmacological properties, which include neuroprotective, pro, antimalarial, anticancer effects, therapeutic advantages Lys for CRC remain uncertain. In this study, we demonstrated that successfully inhibited cell proliferation, migration, invasion HCT116 SW480 cells...

Abstract The expression of legumain which has been shown overexpressed in patients with metastatic gastric cancer is positively correlated to both disease progression and outcome, negatively microRNA (miR)−3978 expression. RNA-binding protein, poly r(C) binding protein 1 (PCBP1) was the most downregulated tissue specimens. Quantitative real-time PCR showed that PCBP1 transcriptionally peritoneal metastasis tissues. RNA immunoprecipitation experiments miR-3978 are sequestered normal tissue,...

Radiotherapy (RT) is commonly used to treat multi-tumors attenuate the risk of recurrence. Despite impressive initial clinical responses, a large proportion patients experience resistance RT. Therefore, identification functionally relevant biomarkers would be beneficial for radioresistant patients. Adenosine monophosphate-activated kinase (AMPK) recognized as mediator tumor suppressor gene function. In present study, radio-sensitive and -resistant colon cancer patient samples were compared...

In China, majority of the mortality in gastric cancer are associated with peritoneal metastasis. Since most tumors metastatic at initial diagnosis, treatment is limited to radical resection. Therefore, it imperative identify diagnostic and prognostic biomarkers. From 2014 2015, 20 patients were enrolled study. To search translationally upregulated genes context epithelial mesenchymal transition (EMT), polysome profiling was performed. The MTT, migration invasion assay conducted determine...

Pyroptosis, a pro-inflammatory and lytic programmed cell death pathway, possesses great potential for antitumor immunotherapy. By releasing cellular contents large number of factors, tumor pyroptosis can promote dendritic maturation, increase the intratumoral infiltration cytotoxic T cells natural killer cells, reduce immunosuppressive within tumor. However, efficient induction prevention damage to normal tissues or is an urgent concern be addressed. Recently, wide variety nanoplatforms have...

Autophagy is a common phenomenon in cancer metabolism. However the mechanism and guiding significance of autophagy development gastric has remained to be elucidated. In present study, 75 tissue specimens were collected at The China Japan Union Hospital Jilin University (Changchun, China). Of these samples, 16 cases stage 1, 40 2 19 3. Polymerase chain reaction western blotting used detect messenger RNA protein expression Beclin-1, significant associated with cellular autophagy. It was found...

// Yi Zhang 1 , Yuan-yu Wu Jun-nan Jiang Xue-song Liu Fu-jian Ji Xue-dong Fang Department of General Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130012, China Correspondence to: Fang, email: fangxuedong@medmail.com.cn Ji, jifj@jlu.edu.cn Keywords: gastric cancer, miRNA-3978, legumain, metastasis Received: July 06, 2016      Accepted: September 21, Published: October 26, 2016 ABSTRACT Gastric cancer incidence and mortality are among the highest...

Breast cancer is the first noticeable disease in female patients. Long-term use of soybean (Glycine max) may prevent progression cancer. However, molecular mechanism for functions remains unclear. Histone demethylase JMJD5, an important epigenetic molecule, overexpressed breast suggesting that ameliorate by affecting expression JMJD5.To test hypothesis, human cell lines MCF-7 and MDA-MB-231 were treated with different concentrations and/or transfected plasmids pcDNA3.1-JMJD5 pTZU6 +...

Recent studies have demonstrated that circular RNA AKT3 (circAKT3) plays a crucial role in regulating the malignant phenotypes of tumor cells. However, potential effects circAKT3 on esophageal cancer not been investigated.To illuminate behaviors cells and its underlying mechanism.Clinical samples were collected to detect expression circAKT3. The proliferation, migration, invasion, apoptosis was evaluated using Cell Counting Kit-8, wound healing assays, Transwell fluorescence analysis,...

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Gastric cancer is one of the most virulent malignant diseases and second leading cause mortality in world. The receptor tyrosine kinase MET constitutively activated many gastric cancers its expression strictly required for survival some cells. Targeting with amplified or abnormally may have therapeutic benefit based on nonclinical emerging clinical findings. However, major problems therapies targeting kinases that tumors are not responsive to treatment eventually develop resistance drugs....

The aim of the present study was to investigate function microRNA-543 on liver cancer cell proliferation and apoptosis, also identify whether Janus kinase 2 (JAK2)/signal transducer activator transcription 3 (STAT3) signaling pathway a direct target microRNA-543. When compared with paracarcinoma tissue, expression in tissue samples from patients identified be decreased. Furthermore, overall survival high increased low expression. Inhibition decreased apoptosis cells. It activated protein...

Gastric cancer is the most prominent form of malignancy in China, and high mortality associated with it mostly due to peritoneal metastasis. We have previously elucidated that RNA-binding protein poly r(C) binding 1 (PCBP1) miR-3978 function as repressors metastasis, partially by downregulation six-transmembrane epithelial antigen prostate (STEAP1). now show STEAP1 regulated at level cap-dependent translation initiation phosphorylated eIF4E. Chemically inhibiting phosphorylation eIF4E or...