A5003438535- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Misinformation and Its Impacts
- RNA modifications and cancer
- Ophthalmology and Eye Disorders
- Cancer-related molecular mechanisms research
- Fire effects on ecosystems
- MicroRNA in disease regulation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Plant Molecular Biology Research
- Hematopoietic Stem Cell Transplantation
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Traditional Chinese Medicine Analysis
- Mesenchymal stem cell research
- Photosynthetic Processes and Mechanisms
- Sarcoma Diagnosis and Treatment
- Phytochemicals and Antioxidant Activities
- Peroxisome Proliferator-Activated Receptors
- Public Relations and Crisis Communication
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Corneal surgery and disorders
- Plant nutrient uptake and metabolism
- Advancements in Battery Materials
Jilin University
2014-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Peking Union Medical College Hospital
2018-2025
Fujian Agriculture and Forestry University
2024-2025
China Tobacco
2025
Wenzhou Medical University
2020-2024
Affiliated Eye Hospital of Wenzhou Medical College
2020-2024
Dalian University of Technology
2024
Chinese Academy of Fishery Sciences
2024
Southern Medical University
2020-2024
Peritoneal metastasis (PM) is the main site of gastric cancer (GC) distant and indicates an extremely poor prognosis survival. Hypoxia a common feature peritoneal metastases up-regulation hypoxia inducible factor 1 alpha (HIF-1α) may be potential driver in occurrence PM. Ferroptosis recently discovered form regulated cell death closely related to development tumors. However, underlying mechanism link HIF-1α ferroptosis PM GC remains unknown. Here, lncRNA-microarrays RNA library...
The outbreak of severe acute respiratory syndrome (SARS) in 2003 marked the explosion health information seeking online China and increasing emergence Chinese websites. There are both benefits potential hazards people's seeking. This article intended to test part Wilson's second model behavior, including source characteristics activating mechanisms, identify relationships among perceived access, expertise credibility, reward assessment, Internet self-efficacy, information-seeking behavior....
Chronic stress could induce cancer metastasis by constant activation of the sympathetic nervous system, while cellular mechanism remains obscure. The aim this research is to explore associated negative effect chronic stress. analysis transcriptome sequencing implied that STAT3 signaling pathway downregulated miR-337-3p might be a potential epithelial mesenchymal transition (EMT) cell and promote under We also verified biological process in further experiments. Downregulation downregulate...
Abstract Background The interaction between the tumor-microenvironment (TME) and cancer cells has emerged as a key player in colorectal (CRC) metastasis. A small proportion of CRC which undergo epithelial-mesenchymal transition (EMT) facilitate reshaping TME by regulating various cellular ingredients. Methods Immunohistochemical analysis, RNA immunoprecipitation (RIP), Antisense Purification (RAP), dual luciferase assays were conducted to investigate biological function regulation LINC00543...
This study aimed to investigate the protective effect of metformin on trabecular meshwork (TM) and explore its molecular mechanisms in vivo vitro. Ocular hypertension (OHT) mouse models were induced with dexamethasone further treated determine intraocular pressure (IOP)-lowering effect. Cultured human TM cells (HTMCs) pre-stimulated tert-butyl hydroperoxide (tBHP) induce oxidative damage then supplemented for another 24 hr. The expression fibrotic markers integrin/Rho-associated kinase...
Tumor necrosis factor alpha (TNF-α) is considered to play an important role in the pathogenesis IgA nephropathy (IgAN). The correlations between serum TNF-α and disease severity patients with IgAN remain controversial. Concentrations of 147 126 healthy subjects were measured by chemiluminescence immunoassay. Correlations clinicopathological features evaluated. Serum levels [9.20 (7.70–10.60) pg/mL vs. 6.04 (5.11–7.23) pg/mL, P < 0.0001] higher than that subjects. Receiver operating...
Gastric cancer is anatomically proximal to peritoneum. peritoneal metastasis a complex biological process which corresponded with disharmony within dysfunctional adipose tissue and metabolism reprogramming. Laminin gamma 1 (LAMC1) highly expressed in cells of metastatic sites, however, the mechanism LAMC1-metiated gastric metastases tissue-rich peritoneum remains unclear. In our study, immunohistochemical staining, single cell sequencing, co-culture model, luciferase reporter, RNA...
Metabolic dysregulations have emerged as a major mediator of cardiovascular disorders and fibrotic diseases. reprogramming contributes lot to cardiac fibroblast activation fibrosis post-myocardial infarction (MI), yet the mechanism remains incompletely understood. Our work aimed determine whether or not glycolytic reprogramming, regulated by phosphofructokinase-2/fructose-2,6-bisphosphatase 3 (PFKFB3), is therapeutic target for alleviating post-MI fibrosis. Here, we showed that fibroblasts...
Chickenpox is an old but easily neglected infectious disease. Although chickenpox preventable by vaccines, vaccine breakthroughs often occur, and the epidemic on rise. not included in list of regulated communicable diseases that must be reported controlled public health departments; therefore, it crucial to rapidly identify report varicella outbreaks during early stages. The Baidu index (BDI) can supplement traditional surveillance system for diseases, such as brucellosis dengue, China....
Abstract A fast method that combines inert gas fusion with infrared absorption spectrometry for determination of total oxygen in FeSiAl magnetic alloy has been established. The whole analyzing process was introduced, especially the selection sample weight, analytical power, fluxes and calibration. blank test, precision test spiked recovery were conducted to verify suitability accuracy proposed method. Limit quantifications range 0.010% 0.012%, while relative standard deviations less 9.5%....
The biochemical and transcriptional regulatory mechanisms of chlorophyll metabolism have been extensively studied, but the translational remain poorly understood. In this study, we found that NtDHS1 deficiency in N. tabacum resulted smaller leaves increased leaf content. Protein content determination experiments revealed global protein synthesis Ntdhs1 mutant was decreased. A ribosome profiling sequence (Ribo-seq) assay showed translation level genes related to cell growth significantly...
This study presents the glacial geomorphology and chronology of Gongba Mountain area in Daocheng (28&#176;58'N, 100&#176;23'E), located southeastern sector Tibetan Plateau, an important region influenced by significant climatic oscillations during Quaternary. Utilizing advanced remote sensing technologies, we generate a high-resolution Digital Elevation Model (DEM) with aid Uncrewed Aerial Vehicle (UAV) to map this sector. We supplement our DEM mapping satellite imagery (SPOT, ArcGIS...
Abstract Increased acid phosphatase (APase) activity is a prominent feature of tomato ( Solanum lycopersicum ) responses to inorganic phosphate (Pi) restriction. SlPHL1, starvation response (PHR) transcription factor, has been identified as positive regulator low Pi (LP)‐induced APase in tomato. However, the molecular mechanism underlying this regulation remains be elucidated. Here, SlPHL1 was found positively regulate LP‐induced expression five potential purple (PAP) genes, namely SlPAP7 ,...