Hua Wen

ORCID: 0000-0003-2798-8437
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About
Contact & Profiles
Research Areas
  • Aquaculture Nutrition and Growth
  • Aquaculture disease management and microbiota
  • Asthma and respiratory diseases
  • Fish Biology and Ecology Studies
  • Animal Nutrition and Physiology
  • Reproductive biology and impacts on aquatic species
  • Physiological and biochemical adaptations
  • Aquatic life and conservation
  • Animal Genetics and Reproduction
  • Respiratory and Cough-Related Research
  • Crustacean biology and ecology
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Protein Hydrolysis and Bioactive Peptides
  • HVDC Systems and Fault Protection
  • Adipose Tissue and Metabolism
  • High-Voltage Power Transmission Systems
  • Meat and Animal Product Quality
  • Peroxisome Proliferator-Activated Receptors
  • Antioxidant Activity and Oxidative Stress
  • IL-33, ST2, and ILC Pathways
  • Environmental Toxicology and Ecotoxicology
  • Retinoids in leukemia and cellular processes
  • Fish Ecology and Management Studies
  • Vitamin C and Antioxidants Research
  • Biochemical effects in animals

Chinese Academy of Fishery Sciences
2016-2025

Ministry of Agriculture and Rural Affairs
2019-2025

Second Affiliated Hospital of Zhejiang University
2013-2024

Hechi University
2024

Zhejiang Chinese Medical University
2022

Zhejiang University
2010-2020

Yangtze University
2019

Fruit Research Institute
2015

Huazhong Agricultural University
2008-2014

Anhui Agricultural University
2014

Continuous turnover of intracellular components by autophagy is necessary to preserve cellular homeostasis in all tissues. Despite recent advances identifying autophagy-related genes and understanding the functions developmental pathological conditions, so far, role platelet, a specific anucleate cell type, poorly understood. In this study, we showed that human platelets express proteins ATG5, ATG7, LC3. The same as nucleated mammalian cells, was stimulated starvation or MTOR inhibitor...

10.4161/auto.27832 article EN Autophagy 2014-01-21

A 9-week feeding experiment was conducted to investigate the effects of dietary bile acids (BAs) on juvenile genetically improved farmed tilapia (GIFT) (Oreochromis niloticus) based evaluations growth performance and parameters relevant lipid metabolism. Each five vegetable protein-based diets containing BAs at a level 0, 0.05, 0.15, 0.45 or 1.35 g/kg diet fed three replicates with 40 fish (8.2 g per fish). The results showed that weight gain (WG) increased significantly increase in from 0...

10.1111/anu.12656 article EN Aquaculture Nutrition 2018-01-22

Mucus hypersecretion is a common pathological feature of chronic airway inflammatory diseases including obstructive pulmonary disease (COPD). However, the molecular basis for this condition remains incompletely understood. We have previously demonstrated critical role autophagy in COPD pathogenesis through mediating apoptosis lung epithelial cells. In study, we aimed to investigate function as well its upstream and downstream signals cigarette smoke-induced mucus production human bronchial...

10.1152/ajplung.00418.2015 article EN AJP Lung Cellular and Molecular Physiology 2016-04-02

It is currently not understood whether cigarette smoke exposure facilitates sensitisation to self-antigens and ensuing auto-reactive T cells drive chronic obstructive pulmonary disease (COPD)-associated pathologies. To address this question, mice were exposed for 2 weeks. Following a 2-week period of rest, challenged intratracheally with elastin 3 days or 1 month. Rag1 −/− , Mmp12 Il17a neutralising antibodies against active fragments used mechanistic investigations. Human...

10.1183/13993003.00404-2020 article EN European Respiratory Journal 2020-05-04

This study was conducted to investigate the effects of dietary protease on growth performance, feed utilization, whole-body proximate composition, nutrient digestibility, intestinal and hepatopancreas structure juvenile Gibel carp, Carassius auratus gibelio (mean weight 8.08 ± 0.18 g). Six diets were prepared, including a positive control diet (dietary protein 350 g/kg, PC), one negative 33 NC) four supplementations diets, which 75, 150, 300 600 mg/kg NC diet. After 12 weeks feeding in...

10.1111/anu.12531 article EN Aquaculture Nutrition 2017-02-22

Tilapia is one of the most important economic and fastest-growing species in aquaculture worldwide. In 2015, an epidemic associated with severe mortality occurred adult tilapia Hubei, China. The causative pathogen was identified as parvovirus (TiPV) by virus isolation, electron microscopy, experimental challenge, situ hybridization (ISH), indirect immunofluorescence (IFA), viral gene sequencing. Electron microscopy revealed large numbers particles organs diseased fish, including kidney,...

10.1371/journal.ppat.1008765 article EN cc-by PLoS Pathogens 2020-09-24

The present study aimed to compare the nutritional effects of cholesterol, bile acids, and combination cholesterol with acids in plant-based diets on juvenile genetically improved farmed tilapia (GIFT, Oreochromis niloticus). isonitrogenous (32 g/kg crude protein) isolipidic (76 fat) (Con diet) were based plant protein sources, which included corn gluten meal, soybean cottonseed meal rapeseed meal. Con diet was supplemented 12 (CHO diet), 0.2 (BAs a (CHO-BAs respectively. Each fed three...

10.1016/j.aninu.2024.03.001 article EN cc-by-nc-nd Animal nutrition 2024-03-08

The objective of this study was to assess the impact concentrated cottonseed protein (CPC) as a substitute for fishmeal (FM) in juvenile hybrid culter (Erythroculter ilishaeformis ♀ × Ancherythroculter nigrocauda ♂). A total 360 fish with an initial body weight 10.0 ± 0.5 g were randomly allocated into 12 indoor culture tanks, each tank containing 30 fish. Four diets formulated which meal replaced by CPC at different inclusion levels: 0% (T0), 15% (T15), 30% (T30), and 45% (T45)....

10.3390/fishes9040127 article EN cc-by Fishes 2024-03-31

To evaluate the effects of dietary supplementation with succinic acid on growth performance, flesh quality, glucose, and lipid metabolism Nile tilapia (

10.1016/j.aninu.2024.04.016 article EN cc-by-nc-nd Animal nutrition 2024-05-25

This study was conducted to evaluate the effect of dietary protein levels on growth performance, muscle composition, digestive enzymes activities, hemolymph biochemical indices and ovary development pre-adult red swamp crayfish Procambarus clarkii (initial weight = 12.86 ± 0.10 g). Six isoenergetic diets (fish meal, soybean gluten, shrimp powder as main sources) were formulated contain graded 20.70 %, 24.70 30.56 35.77 41.12 % 44.64 crude protein. Each diet assigned triplicate groups 15...

10.1016/j.aqrep.2020.100542 article EN cc-by-nc-nd Aquaculture Reports 2020-11-01

Dietary protein is one of the most important nutritional factors in aquaculture. The aim this study was to examine effects dietary levels on gut microbiome and liver serum metabolites tilapia. Tilapia were fed a diet with low (20%), moderate (30%), or high (40%) content crude protein, homeostasis metabolic profile analyzed. results showed no significant differences diversity richness among groups; however, there microbial composition gut. metabolome analysis samples revealed difference...

10.3390/ani11041024 article EN cc-by Animals 2021-04-05

The mammalian target of rapamycin (mTOR) signalling pathway regulates immune responses, and promotes cell growth differentiation. Inhibition mTOR with modulates allergic asthma, while the underlying molecular mechanisms remain elusive. Here, we demonstrate that rapamycin, effectively inhibits eosinophil differentiation, contributing to its overall protective role in airway inflammation.Rapamycin was administered a mouse model ovalbumin-induced inflammation, differentiation analysed vivo...

10.1111/resp.12554 article EN Respirology 2015-06-04
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