Jiexin Zhang
A5016356014- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Extracellular vesicles in disease
- Parathyroid Disorders and Treatments
- Cancer-related gene regulation
- Genomics and Rare Diseases
- Protease and Inhibitor Mechanisms
- Reproductive System and Pregnancy
- Genomics and Chromatin Dynamics
- Prenatal Screening and Diagnostics
- MicroRNA in disease regulation
- Plant-Microbe Interactions and Immunity
- Cytomegalovirus and herpesvirus research
- Pregnancy and preeclampsia studies
Third Affiliated Hospital of Southern Medical University
2025
Key Laboratory of Guangdong Province
2025
Nanjing Medical University
2015-2024
Jiangsu Province Hospital
2015-2024
Guangdong Academy of Agricultural Sciences
2023-2024
National Center for Clinical Laboratories
2022-2024
Ministry of Agriculture and Rural Affairs
2023
Southwest Jiaotong University
2023
Peking Union Medical College Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
We conducted comprehensive integrative molecular analyses of the complete set tumors in The Cancer Genome Atlas (TCGA), consisting approximately 10,000 specimens and representing 33 types cancer. performed clustering using data on chromosome-arm-level aneuploidy, DNA hypermethylation, mRNA, miRNA expression levels reverse-phase protein arrays, which all, except for revealed primarily organized by histology, tissue type, or anatomic origin. influence cell type was evident...
Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings tumor-infiltrating lymphocytes (TILs) based on H&E from 13 tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches images. Affinity propagation revealed local spatial structure in patterns correlation with overall survival. map...
The Cancer Genome Atlas (TCGA) cancer genomics dataset includes over 10,000 tumor-normal exome pairs across 33 different types, in total >400 TB of raw data files requiring analysis. Here we describe the Multi-Center Mutation Calling Multiple Cancers project, our effort to generate a comprehensive encyclopedia somatic mutation calls for TCGA enable robust cross-tumor-type analyses. Our approach accounts variance and batch effects introduced by rapid advancement DNA extraction,...
We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared distinguishing molecular characteristics gastrointestinal tract (GIACs). Hypermutated tumors were distinct regardless cancer type comprised those enriched for insertions/deletions, representing microsatellite instability cases with epigenetic silencing MLH1 in context CpG island methylator phenotype, plus elevated single-nucleotide variants associated mutations POLE. Tumors chromosomal diverse,...
We characterized the epigenetic landscape of genes encoding long noncoding RNAs (lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to CpG island hypermethylation phenotype in cancer, we observed a recurrent hypomethylation 1,006 lncRNA including EPIC1 (epigenetically-induced lncRNA1). Overexpression is associated with poor prognosis luminal B breast patients enhances tumor growth vitro vivo. Mechanistically, promotes cell-cycle progression by interacting MYC through...
Highlights•MYC paralogs are significantly amplified (28% of all samples)•MYC antagonists mutated (MGA, 4% samples) or deleted (MNT, 10% alterations mutually exclusive with PIK3CA, PTEN, APC, BRAF alterations•Expression analysis reveals pan-cancer and tumor-specific MYC-associated pathwaysSummaryAlthough the MYC oncogene has been implicated in cancer, a systematic assessment MYC, related transcription factors, co-regulatory proteins, forming proximal network (PMN), across human cancers is...
Highlights•An overview of PanCancer Atlas analyses on oncogenic molecular processes•Germline genome affects somatic genomic landscape in a pathway-dependent fashion•Genome mutations impact expression, signaling, and multi-omic profiles•Mutation burdens drivers influence immune-cell composition microenvironmentSummaryThe Cancer Genome (TCGA) has catalyzed systematic characterization diverse alterations underlying human cancers. At this historic junction marking the completion over 11,000...
Abstract Severe acute respiratory syndrome‐related coronavirus 2 (SARS‐CoV‐2) seriously threatens public health and safety. Genetic variants determine the expression of SARS‐CoV‐2 structural proteins, which are associated with enhanced transmissibility, virulence, immune escape. Vaccination is encouraged as a intervention, different types vaccines used worldwide. However, new continue to emerge, especially Omicron complex, neutralizing antibody responses diminished significantly. In this...
Cytokines secreted by adipose tissue macrophages (ATMs) significantly alter adipocyte function, inducing inflammatory responses and decreasing insulin sensitivity. However, little relevant information is available regarding the role of microvesicles (MVs) derived from ATMs in macrophage-adipocyte crosstalk.MVs were generated stimulation M1 or M2 phenotype THP-1 incubated with human primary mature adipocytes differentiated adipocytes. Subsequently, insulin-stimulated phosphorylation Akt...
The process of tendon-to-bone healing is regulated by several proteins and cytokines that play critical roles in shaping biomechanical properties functional recovery. Among these, the ubiquitin-like protein ISG-15 has been reported to have a beneficial effect on tissue repair. However, its specific function interface regeneration not well characterized. This study investigated ISG15 vitro addressed vivo effects tendon bone healing. In this study, wild-type C57/BL6 mice underwent anterior...
Mesenchymal stem cells (MSCs) and hepatocytes are two attractive sources of cell-based therapies for acute liver failure (ALF). The cotransplantation with MSCs can improve the therapeutic performance treatment ALF. However, potential conditioned medium (CM) derived from cocultured (MSC-H-CM) remains unclear. purpose this study was to investigate effects MSC-H-CM on damaged in vitro D-galactosamine-induced ALF vivo . D-Galactosamine-treated L02 cultured exhibited higher cell viability total...
Bacillus velezensis is well known as a plant growth-promoting rhizobacteria (PGPR) and biocontrol agent. Nevertheless, there are very few reports on the study of B. tomato early blight, especially effects among different inoculation concentrations. In this study, an IAA-producing strain, YXDHD1-7 was isolated from rhizosphere soil, which had strongest inhibitory effect against Alternaria solani. Inoculation with bacterial suspensions strain promoted growth seedlings effectively. Furthermore,...
Abstract Background CD2‐associated protein (CD2AP) is a podocyte‐associated gene and its reduced expression associated with the development of proteinuria glomerulosclerosis. However, few studies have focused on correlation between prognosis CD2AP in renal clear cell carcinoma (ccRCC). Therefore, we aimed to assess regulation prognostic value ccRCC. Methods Multiple databases were employed examine RT‐qPCR, Western Blot immunohistochemistry used validate different lines tissue samples....
Tomato cultivars with contrasting resistance to pathogens regulate root exudates differentially in response Ralstonia solanacearum attacks. However, strategies using innate against infection remain unknown. This study analyzed the of two tomato and their functions regulating R. infection. The differed between cultivars. Astaxanthin released from resistant plants inhibited colonization by but promoted motility, while neferine susceptible suppressed motility colonization. secretion astaxanthin...
Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a widely secreted protein that regulates cell motility, proliferation, and apoptosis. Although it recognized TIMP-1-tetraspanin CD63 epithelial apoptosis how TIMP-1 controls motility not well understood. In this study, we identify tetraspanin CD82 (also called KAI1) as component the promiscuous interacting complex on surface human pancreatic adenocarcinoma cells. directly binds to N-terminal region through its large extracellular loop...
The mechanism for pathogenesis of human papillomavirus (HPV) in the cervix has been investigated intensively. However, detailed differences distribution and function innate immune cells between high-risk HPV types, especially during chronic inflammation phase, have not described fully. In this study, histologic pathology results 245 women with type 16 only (HPV16 + ) or 18 (HPV18 were analyzed retrospectively from January 2015 to November 2016. More severe lesions observed HPV16 compared...
Introduction Chronic viral hepatitis (CH) is a stage prior to cirrhosis and primary cancer. Standard protocols for CH assessment during the long follow-up period are of great importance precise treatment living quality improvement. In this study, we aimed analyze multiple serum indexes in chronic B (CHB)-infected patients discuss their combined values clinical applications. Methods Total 503 lines laboratory data from 2012 2021 were extracted from103 CHB who followed-up our hospital. They...