A5101660024- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- RNA regulation and disease
- Crustacean biology and ecology
- RNA modifications and cancer
- Signaling Pathways in Disease
- Reproductive biology and impacts on aquatic species
- Aquatic life and conservation
- Toxin Mechanisms and Immunotoxins
- CAR-T cell therapy research
- Photoreceptor and optogenetics research
- Liver Disease and Transplantation
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Organophosphorus compounds synthesis
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Protein Hydrolysis and Bioactive Peptides
- Liver Disease Diagnosis and Treatment
- Cellular transport and secretion
- Insect Utilization and Effects
- Cardiomyopathy and Myosin Studies
- Seaweed-derived Bioactive Compounds
McGill University Health Centre
2023-2024
McGill University
2020-2024
Ministry of Agriculture and Rural Affairs
2023-2024
AstraZeneca (United Kingdom)
2024
Texas A&M University
2022-2024
AstraZeneca (United States)
2022-2024
College Station Medical Center
2024
University of California, Merced
2024
Shenzhen Second People's Hospital
2024
National Taiwan University
2016-2022
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in variants that can escape neutralization by therapeutic antibodies. Here, we describe AZD3152, a SARS-CoV-2–neutralizing monoclonal antibody designed to provide improved potency and coverage against emerging variants. AZD3152 binds the back left shoulder SARS-CoV-2 spike protein receptor binding domain prevents interaction with human angiotensin-converting enzyme receptor. potently neutralized broad...
This study was conducted to evaluate the effect of dietary protein levels on growth performance, muscle composition, digestive enzymes activities, hemolymph biochemical indices and ovary development pre-adult red swamp crayfish Procambarus clarkii (initial weight = 12.86 ± 0.10 g). Six isoenergetic diets (fish meal, soybean gluten, shrimp powder as main sources) were formulated contain graded 20.70 %, 24.70 30.56 35.77 41.12 % 44.64 crude protein. Each diet assigned triplicate groups 15...
The present study aimed to assess the role of tributyrin (TB) in regulating growth and health status juvenile blunt snout bream ( Megalobrama amblycephala ) through an 8-week feeding experiment. Six groups were fed experimental diets with added TB percentages 0% (control group), 0.03%, 0.06%, 0.09%, 0.12% 0.15%. results showed that supplementation feed had some positive impacts on FW, WG, FCR SGR, best found 0.06% group P<0.05 ). However, no significant effects SR, CF, VSI or...
Abstract Hepatic encephalopathy (HE) is defined as decline in neurological function during chronic liver disease (CLD). Alcohol a major etiological factor the pathogenesis of fibrosis/cirrhosis and has also been documented to directly impact brain. However, role alcohol development HE CLD remains unclear. Here, we investigated excessive administration on deterioration rats with CLD. Starting day 7 post‐BDL surgery, were administered twice daily (51% v/v ethanol, 3 g/kg, via gavage) for 4...
We tested the hypothesis that in vitro nicotine exposure disrupts specific epithelial-mesenchymal paracrine signaling pathways and results pulmonary interstitial lipofibroblast (LIF)-to-myofibroblast (MYF) transdifferentiation, resulting altered development function. Studies were done to determine whether induces LIF-to-MYF transdifferentiation elucidate underlying molecular mechanism(s) involved nicotine-induced could be prevented by stimulating alveolar fibroblast lipogenic pathway. WI38...
The role of RNA binding proteins in regulating the phagocytic and cytokine-releasing functions microglia is unknown. Here, we show that deficient for QUAKING (QKI) protein have increased proinflammatory cytokine release defects processing phagocytosed cargo. Splicing analysis reveals a QKI microexon networks Rho GTPase pathway. We an increase RhoA activation cytokines QKI-deficient are repressed by treating with Rock kinase inhibitor. During cuprizone diet, mice inefficient at supporting...
A 56-day feeding experiment was conducted to determine the dietary lysine requirement of juvenile largemouth bass (Micropterus salmoides) and investigate effects on growth, whole-body composition, hepatic gene expression related glycolipid metabolism via AKT/FoxO1 pathway. The juveniles ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mn>17.34</mn> <mo>±</mo> <mn>0.02</mn> </math> g) were fed six graded levels (2.11% (control), 2.56%, 2.92%, 3.33%, 3.68%, 4.09%, dry diet)....
Lymphocytes depend on transmethylation reactions for efficient activation and function. These are primarily catalyzed by <i>S</i>-adenosylmethionine-dependent methyltransferases, which convert <i>S</i>-adenosylmethionine to <i>S</i>-adenosyl-l-homocysteine. <i>S</i>-adenosyl-l-homocysteine is then hydrolyzed hydrolase prevent feedback inhibition of reactions. By impeding hydrolase, a build-up occurs, most intracellular cease. Thus, nontoxic inhibitor this enzyme might be useful...
We have used adenosine diphosphate analogs containing electron paramagnetic resonance (EPR) spin moieties and EPR spectroscopy to show that the nucleotide-binding site of kinesin-family motors closes when motor.diphosphate complex binds microtubules. Structural analyses demonstrate a domain movement in switch 1 region at nucleotide site, homologous movements G proteins [heterotrimeric guanine proteins], explains data. The primes motor both for free energy-yielding hydrolysis reaction...
Abstract Transmethylation affects several cellular events, including T cell activation, and blockade of this pathway may curtail inflammatory/autoimmune responses. Here, we demonstrate that transmethylation inhibition by a novel reversible S-adenosyl-l-homocysteine hydrolase inhibitor leads to immunosuppression reducing phosphorylation key proteins involved in TCR signaling, Akt, Erk1/2, NF-κB. Remarkably, effect was largely restricted CD4 cells correlated with reduced arginine methylation...
This study explored the role of dietary arginine level (DAL) on growth, intestinal antioxidant status and immune response in juvenile largemouth bass (Micropterus salmoides), providing guidance for optimization commercial feed bass. Six graded levels diets were fed to fish 8 weeks (1.96%, 2.28%, 2.52%, 2.81%, 3.09% 3.35% diets). The findings as follows: with increasing DALs, FW, WG SGR increased first decreased, FCR showed opposite trend. There was no difference contents crude protein ash...
Abstract Background EVUSHELD was developed for the prevention and treatment of mild-to-moderate COVID-19 high-risk individuals. However, SARS-CoV-2 virus continues to evolve in presence natural- vaccine-acquired immunity, escaping previously authorized antibody therapies such as bebtelovimab EVUSHELD. AZD3152 selected neutralize all known variants concern is being provide immunocompromised individuals with continued protection against SARS-CoV-2. Methods Structural analyses were performed...
Regulated hydrolysis of the phosphoinositide phosphatidylinositol(4,5)-bis-phosphate to diacylglycerol and inositol-1,4,5-P3 defines a major eukaryotic pathway for translation extracellular cues intracellular signaling circuits. Members lipid-activated protein kinase C isoenzyme family (PKCs) play central roles in this circuit. One regulatory mechanisms employed downregulate stimulated PKC activity is via proteasome-dependent degradation that potentiated by peptidyl-prolyl isomerase Pin1....
Recently, the global supply shortage of fish oil (FO) has resulted in rapid price increases, and aquatic feed is largest consumption FO. Black soldier fly larvae (Hermetia illucens) (HIO) rich lauric acid been suggested as a possible source lipids for diet. The current study aims to evaluate whether it feasible replace FO Pacific white shrimp (Litopenaeus vannamei) (4.95 ± 0.10 g) with HIO investigate effects this substitution on growth, biochemical indices, approximately composition,...
A suitable feed size has a positive effect on animal feeding. For aquatic larvae, the correct is very important for their growth. This experiment analyzed and compared of different particle sizes larval stages growth performance, whole body composition, muscle amino acid fatty composition crayfish. Five crayfish diets sizes, namely < 0.40 mm (Group A, control group), 0.40-0.50 B), 0.71-0.85 C), 0.90-1.00 D) 1.5 E), were fed to 2000 (initial weight 0.0786 ± 0.0031 g) 100 d. The results showed...