A5091310657- Enzyme Catalysis and Immobilization
- Trace Elements in Health
- Ionic liquids properties and applications
- Plant Micronutrient Interactions and Effects
- Electrochemical sensors and biosensors
- Signaling Pathways in Disease
- Organometallic Complex Synthesis and Catalysis
- Toxin Mechanisms and Immunotoxins
- Fuel Cells and Related Materials
- Chemical Synthesis and Analysis
- Biochemical and Molecular Research
- Polyoxometalates: Synthesis and Applications
- Genetics, Aging, and Longevity in Model Organisms
- Advanced Battery Technologies Research
- Carbohydrate Chemistry and Synthesis
- Iron Metabolism and Disorders
- Asymmetric Hydrogenation and Catalysis
- Heavy metals in environment
- Aluminum toxicity and tolerance in plants and animals
- Peptidase Inhibition and Analysis
- Mitochondrial Function and Pathology
- Catalytic Processes in Materials Science
- biodegradable polymer synthesis and properties
- Enzyme Structure and Function
- Chemistry and Chemical Engineering
Texas A&M University
2024
University of Manchester
2024
Queen's University Belfast
2019-2023
Belfast City Hospital
2021
University of Ulster
2021
University of St Andrews
2019
St. Andrews University
2019
University of Warwick
2013-2018
Coventry (United Kingdom)
2018
Shahjalal University of Science and Technology
2010
The entrapment of enzymes in organic, inorganic or biomaterials can yield active immobilized biocatalysts for chemical transformations without the need to form covalent bonds with protein.
Reported herein is an entrapment method for enzyme immobilization that does not require the formation of new covalent bonds. Ionic liquid supramolecular gels are formed containing enzymes can be shaped into gel beads and act as recyclable immobilized biocatalysts. The was from two components, a hydrophobic phosphonium ionic low molecular weight gelator derived amino acid phenylalanine. Gel-entrapped lipase Aneurinibacillus thermoaerophilus recycled 10 runs over 3 days without loss activity...
Materials have been developed that encapsulate a homogeneous catalyst and enable it to operate as heterogeneous in water. A hydrophobic ionic liquid within the material was used dissolve Fe-TAML keep from leaching into aqueous phase. One-pot processes were entrap basic gels, gel spheres structured via modified Stöber synthesis forming SiO2 particles of uniform size. Catalytic activity demonstrated oxidative degradation dyes. entrapped exhibited consistent five recycles. This discovery...
Regulated hydrolysis of the phosphoinositide phosphatidylinositol(4,5)-bis-phosphate to diacylglycerol and inositol-1,4,5-P3 defines a major eukaryotic pathway for translation extracellular cues intracellular signaling circuits. Members lipid-activated protein kinase C isoenzyme family (PKCs) play central roles in this circuit. One regulatory mechanisms employed downregulate stimulated PKC activity is via proteasome-dependent degradation that potentiated by peptidyl-prolyl isomerase Pin1....
Abstract With the increased incidence of tuberculosis (TB) caused by Mycobacterium there is an urgent need for new and better anti-tubercular drugs. N-succinyl- L , -diaminopimelic acid desuccinylase (DapE) a key enzyme in succinylase pathway biosynthesis meso-diaminopimelic (meso-DAP) -lysine. DapE zinc containing metallohydrolase which hydrolyses N-succinyl diaminopimelic ( -NSDAP) to -DAP) succinate. M. (MtDapE) was cloned, over-expressed purified as N-terminal hexahistidine ((His) 6 )...
1,4-Benzoxazines are important motifs in many pharmaceuticals and can be formed by a reaction sequence involving the oxidation of o-aminophenols to their corresponding quinone imine followed an situ inverse electron demand Diels–Alder (IEDDA) cycloaddition with suitable dienophile. Reported herein is development that employs horseradish peroxidase catalyze aminophenols prior IEDDA as more sustainable alternative use conventional stoichiometric oxidants. The synthesis 10 example benzoxazines...
Rh-Containing artificial metalloenzymes based on two mutants of sterol carrier protein_2L (SCP_2L) have been shown to act as hydroformylases, exhibiting significant activity and unexpectedly high selectivity in the hydroformylation alkenes.
The dynamics of metal binding to and transfer from metalloproteins involved in homeostasis are important for understanding cellular distribution ions. dicotyledonous plant Arabidopsis thaliana has two type 4 seed-specific metallothionein homologues, MT4a MT4b, with likely roles zinc(II) homeostasis. These metallothioneins 84% identical, full conservation all metal-binding cysteine histidine residues. Yet, differences their spatial temporal expression patterns suggested divergence biological...
The first characterization of<italic>W08E12.2</italic>,<italic>W08E12.3</italic>,<italic>W08E12.4</italic>and<italic>W08E12.5</italic>, four putative metalloproteins in<italic>C. elegans</italic>. (A) phase contrast microscopy, (B) fluorescence microscopy of<italic>PW08E12.3</italic>;<italic>W08E12.4</italic>::GFP.
Poly(ethylenetarepthalate) (PET)-based polymer electrolyte membranes (PEMs) for fuel cells were successfully prepared by grafting of allyl methacrylate (AMA) and acetate separately onto PET films under UV- radiation. A consequent selective sulfonation the grafted was performed chlorosulfonic acid (ClSO¬3H) milder condition. The reaction proceeded at chains, as a result transformed to PEM. It has been confirmed titrimetric gravimetric analyses well FTIR spectroscopy. ion exchanges capacities...