A5030436042- Signaling Pathways in Disease
- COVID-19 Clinical Research Studies
- Connexins and lens biology
- Dermatological and COVID-19 studies
- Toxin Mechanisms and Immunotoxins
- Transgenic Plants and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Crystallization and Solubility Studies
- Antibiotic Resistance in Bacteria
- Calpain Protease Function and Regulation
- Atherosclerosis and Cardiovascular Diseases
- Heat shock proteins research
- Fluorine in Organic Chemistry
- Tuberculosis Research and Epidemiology
- Protein Structure and Dynamics
- Analytical Chemistry and Chromatography
- Plant-Microbe Interactions and Immunity
- Molecular Sensors and Ion Detection
- Plant Virus Research Studies
- Fungal and yeast genetics research
- Microbial Natural Products and Biosynthesis
- Long-Term Effects of COVID-19
- Cancer therapeutics and mechanisms
- Crystallography and molecular interactions
- Bacteriophages and microbial interactions
Texas A&M University
2020-2024
Gladstone Institutes
2021-2024
Indian Institute of Science Bangalore
2014-2020
Abstract Blood protein extravasation through a disrupted blood–brain barrier and innate immune activation are hallmarks of neurological diseases emerging therapeutic targets. However, how blood proteins polarize cells remains largely unknown. Here, we established an unbiased blood-innate immunity multiomic genetic loss-of-function pipeline to define the transcriptome global phosphoproteome blood-induced polarization its role in microglia neurotoxicity. induced widespread microglial...
Abstract Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19 persistent patients with long COVID experiencing post-acute sequelae of SARS-CoV-2 infection 1–4 . Despite the clinical evidence 1,5–7 , underlying mechanisms coagulopathy its consequences inflammation neuropathology remain poorly understood treatment options insufficient. Fibrinogen, central structural component blood clots, is abundantly deposited lungs brains COVID-19, correlates disease...
Aniline-phenol recognition is studied in the crystal engineering context several 1:1 cocrystals that contain a closed cyclic hydrogen-bonded [⋯O-H⋯N-H⋯]2 tetramer supramolecular synthon (II). Twelve of 3,4,5- and 2,3,4-trichlorophenol with one eight halogenated anilines have been characterized. Ten these an extended octamer assembled hydrogen bonding π⋯π stacking defines Long-Range Synthon Aufbau Module (LSAM). The design strategy is, therefore, based on construction transferability LSAM,...
Abstract Blood clots are a central feature of coronavirus disease-2019 (COVID-19) and can culminate in pulmonary embolism, stroke, sudden death. However, it is not known how abnormal blood form COVID-19 or why they occur even asymptomatic convalescent patients. Here we report that the Spike protein from severe acute respiratory syndrome 2 (SARS-CoV-2) binds to coagulation factor fibrinogen induces structurally with heightened proinflammatory activity. SARS-CoV-2 virions enhanced...
Regulated hydrolysis of the phosphoinositide phosphatidylinositol(4,5)-bis-phosphate to diacylglycerol and inositol-1,4,5-P3 defines a major eukaryotic pathway for translation extracellular cues intracellular signaling circuits. Members lipid-activated protein kinase C isoenzyme family (PKCs) play central roles in this circuit. One regulatory mechanisms employed downregulate stimulated PKC activity is via proteasome-dependent degradation that potentiated by peptidyl-prolyl isomerase Pin1....
A hallmark of the crystallin proteins is their exceptionally high solubility, which vital for maintaining refractive index eye lens. Human γC-crystallin a major γ-crystallin whose mutant forms are associated with congenital cataracts but three-dimensional structure not known. An earlier study homology model concluded that human has low intrinsic mainly because atypical magnitude and fluctuations its dipole moment. On contrary, high-resolution tertiary determined here shows unequivocally it...
The plant Sesbania mosaic virus [a (+)-ssRNA sobemovirus] VPg protein is intrinsically disordered in solution. For the life cycle, essential for replication and polyprotein processing that carried out by a virus-encoded protease. nuclear magnetic resonance (NMR)-derived tertiary structure of protease-bound shows it to have novel with an α-β-β-β topology. quaternary high-affinity protease–VPg complex (≈27 kDa) has been determined using HADDOCK protocols NMR (residual dipolar coupling,...
ABSTRACT Regulated hydrolysis of the phosphoinositide phosphatidylinositol(4,5)-bis-phosphate to diacylglycerol and inositol-1,4,5-P 3 defines a major eukaryotic pathway for translation extracellular cues intracellular signaling circuits. Members lipid-activated protein kinase C isoenzyme family (PKCs) play central roles in this circuit. One regulatory mechanisms employed downregulate stimulated PKC activity is via proteasome-dependent degradation that potentiated by peptidyl-prolyl...