A5081473027- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Origins and Evolution of Life
- Neuroscience of respiration and sleep
- Plant and Biological Electrophysiology Studies
- Birth, Development, and Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Space Science and Extraterrestrial Life
- Respiratory Support and Mechanisms
- Photoreceptor and optogenetics research
- Infant Nutrition and Health
- Biofield Effects and Biophysics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genetics, Aging, and Longevity in Model Organisms
- Spaceflight effects on biology
- Quantum Mechanics and Applications
- Earth Systems and Cosmic Evolution
- Pulmonary Hypertension Research and Treatments
- Child and Adolescent Health
- Medical Imaging and Pathology Studies
- Fibroblast Growth Factor Research
- Paranormal Experiences and Beliefs
- Asthma and respiratory diseases
- Evolutionary Game Theory and Cooperation
- Peroxisome Proliferator-Activated Receptors
University of California, Los Angeles
2014-2025
UCLA Medical Center
2012-2025
Harbor–UCLA Medical Center
2011-2020
The Lundquist Institute
2006-2018
University of North Texas
2018
University of Manitoba
2018
Adıyaman University
2018
Evolutionary Genomics (United States)
2016-2017
University of Nebraska Medical Center
2015
Universidad Autónoma de Chile
2015
By altering specific developmental signaling pathways that are necessary for fetal lung development, perinatal nicotine exposure affects growth and differentiation, resulting in the offsprings' predisposition to childhood asthma; peroxisome proliferator-activated receptor gamma (PPARγ) agonists can inhibit this effect. However, whether nicotine-induced asthma risk is restricted nicotine-exposed offspring only; it be transmitted next generation; PPARγ would have any effect on process not...
A marked decrease in fetal tracheal fluid flow and an increase pulmonary surfactant efflux were found after infusion of epinephrine into sheep. The data suggest that endogenous catecholamines may play a role preparing the lung for birth.
It has been recognized that male infants are at greater risk of respiratory distress syndrome than female infants. Amniotic fluid was obtained from 73 and 76 fetuses between 28 40 wk gestation. To assess fetal pulmonary maturity, we determined the lecithin-sphingomyelin ratio concentrations saturated phosphatidyl choline cortisol in all these fluids. Analysis covariance showed had higher indexes maturity did The difference degree 1.2 to 2.5 wk, on basis measurements, with females ahead...
Despite tremendous technological and therapeutic advances, bronchopulmonary dysplasia (BPD) remains a leading cause of respiratory morbidity in very low birth weight infants, there are no effective preventive and/or options. We have previously reported that hyperoxia-induced neonatal rat lung injury might be prevented by rosiglitazone (RGZ). Here, we characterize 1) perturbations wingless/Int (Wnt) transforming growth factor (TGF)-beta signaling, 2) structural aberrations morphology...
Homeostasis is conventionally thought of merely as a synchronic (same time) servo-mechanism that maintains the status quo for organismal physiology. However, when seen from perspective developmental physiology, homeostasis robust, dynamic, intergenerational, diachronic (across-time) mechanism maintenance, perpetuation and modification physiologic structure function. The integral relationships generated by cell-cell signaling mechanisms embryogenesis, physiology repair provide needed insight...
Developing rat lung lipofibroblasts express leptin beginning on embryonic day (E) 17, increasing 7- to 10-fold by E20. Leptin and its receptor are expressed mutually exclusively fetal fibroblasts type II cells, suggesting a paracrine signaling “loop.” This hypothesized mechanism is supported the following experimental data: 1) stimulates de novo synthesis of surfactant phospholipid both cells (400% · 100 ng −1 ml 24 h ) adult human airway epithelial (85% ); 2) secreted in amounts that...
Pulmonary neuroendocrine cells (PNECs) in fetuses synthesize gastrin-releasing peptide (GRP, or mammalian bombesin) at high levels, but the role of this hormone lung development has been obscure. The present study demonstrates that bombesin administered for 2 to 4 d toward end gestation utero led increased DNA (days 17 and 18) saturated phosphatidylcholine (SPC) synthesis (day a dose-dependent fashion fetal lung. These kinetics coincide with timing endogenous GRP gene activation untreated...
Intrauterine lung development, culminating in physiological pulmonary surfactant production by epithelial type II (TII) cells, is driven fluid distension through unknown mechanisms. Differentiation of alveolar and mesenchymal cells mediated soluble factors like parathyroid hormone-related protein (PTHrP), a stretch-sensitive TII cell product. PTHrP stimulates paracrine feedback loop leptin, product the mature lipofibroblast (LF). When LFs TIIs are stretched coculture, there fivefold increase...
Parathyroid hormone-related protein (PTHrP) expression is necessary for differentiation of mesenchymal lipofibroblasts, which induce epithelial type II (TII) cell differentiation, both are alveolarization. PTHrP deficiency may be associated with bronchopulmonary dysplasia (BPD), characterized by truncation alveolarization among preterm infants. This supported the baboon model BPD (failure alveolarization) that manifests deficiency. We provide evidence TII downregulated alveolar...
The lecithin/sphingomyelin (L/S) ratio in amniotic fluid is widely used to predict the risk of respiratory-distress syndrome. However, results are unreliable if specimen contaminated or obtained during a complicated pregnancy. We therefore compared predictive value L/S with that concentration saturated phosphatidylcholine (SPC) 322 amniotic-fluid samples, 75 per cent which were pregnancies both. A positive result one predicted development syndrome, taken as an equal less than 2/1 SPC below...
The effect of cortisol (5.5 muM) on primary monolayer cultures trypsin-dispersed lung cells from rabbit fetuses 20-28 days gestation was monitored with respect to (a) cellular growth as determined by DNA content after 72 h, at which time all were in the exponential phase growth, and (b) maturation reflected incorporation [(14)C]-palmitate into saturated lecithin its release culture medium. Cortisol significantly increased prepared 20 day (control: 59.8+/-8.9 nmol DNA/flask; cortisol:...
Rationale: Animal models demonstrate that aberrant gene expression in utero can result abnormal pulmonary phenotypes.Objectives: We sought to identify genes are differentially expressed during airway development and test the hypothesis variants these influence lung function patients with asthma.Methods: Stage 1 (Gene Expression): Differential analysis across pseudoglandular (n = 27) canalicular 9) stages of human was performed using regularized t tests multiple comparison adjustments. 2...
Males have a higher morbidity and mortality for neonatal respiratory distress syndrome (RDS) than females, respond less well to hormone therapy designed prevent RDS by stimulating fetal pulmonary surfactant production. We shown that male fetuses exhibit delayed production of surfactant. tested the hypothesis sex difference in is under hormonal control. Pulmonary was measured as saturated phosphatidylcholine/sphingomyelin ratio (SPC/S) lung lavage rabbits at 26 d gestation. There an...
Asthma is a major public health hazard worldwide. Its transgenerational inheritance has been inferred from epidemiological studies. More recently, using nicotine as proxy for maternal smoking, we have demonstrated that an asthma-like phenotype can be inherited by rat offspring up to two generations, i.e., multigenerationally, after the initial intrauterine exposure. We hypothesized asthma transmission following perinatal exposure not restricted F 2 generation, but it also extends subsequent...