A5100444663- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- EEG and Brain-Computer Interfaces
- Neurosurgical Procedures and Complications
- Immune cells in cancer
- Meningioma and schwannoma management
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Cerebrospinal fluid and hydrocephalus
- Cerebrovascular and Carotid Artery Diseases
- Pituitary Gland Disorders and Treatments
- Anesthesia and Neurotoxicity Research
- Neurological Disease Mechanisms and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Glioma Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Neurogenesis and neuroplasticity mechanisms
- Head and Neck Surgical Oncology
- Anesthesia and Sedative Agents
- Apelin-related biomedical research
- Reproductive Biology and Fertility
Second Affiliated Hospital of Zhejiang University
2016-2025
Capital Medical University
2021-2025
Beijing Children’s Hospital
2021-2025
Zhejiang University
2015-2024
Zhejiang Lab
2016-2024
Yunnan Normal University
2019-2024
Chinese Institute for Brain Research
2015-2024
Shanghai Children's Hospital
2024
Hangzhou Children's Hospital
2024
Chinese Academy of Fishery Sciences
2023-2024
Abstract Background Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Microglial/macrophage activation neuroinflammation are key cellular events following TBI, but the regulatory functional mechanisms still not well understood. Myeloid-epithelial-reproductive tyrosine kinase (Mer), member Tyro-Axl-Mer (TAM) family receptor kinases, regulates multiple features microglial/macrophage physiology. However, its function in regulating innate immune response M1/M2...
Chronic subdural hematoma (CSDH) is a trauma-associated condition commonly found in elderly patients. Surgery currently the treatment of choice, but it carries significant risk recurrence and death. Nonsurgical treatments remain limited ineffective. Our recent studies suggest that atorvastatin reduces hematomas improves clinical outcomes patients with CSDH.To investigate safety therapeutic efficacy to nonsurgically treat CSDH.The Effect Atorvastatin on Subdural Hematoma (ATOCH) randomized,...
Neuroinflammation and oxidative stress play important roles in early brain injury following subarachnoid hemorrhage (SAH). This study is the first to show that activation of apelin receptor (APJ) by apelin-13 could reduce endoplasmic reticulum (ER)-stress-associated inflammation after SAH.Apelin-13, siRNA, APJ adenosine monophosphate-activated protein kinase (AMPK) inhibitor-dorsomorphin were used investigate if provide neuroprotective effects SAH. Brain water content, neurological...
Microglia continuously survey the brain parenchyma and actively shift status following stimulation. These processes demand a unique bioenergetic programme; however, little is known about metabolic determinants in microglia. By mining large datasets generating transgenic tools, here we show that hexokinase 2 (HK2), most active isozyme associated with mitochondrial membrane, selectively expressed microglia brain. Genetic ablation of HK2 reduced microglial glycolytic flux energy production,...
Abstract Purpose: The objective of this study was to evaluate clinical significance and immunosuppressive mechanisms B7-H4 (B7x/B7S1), a B7 family member, in glioma. Experimental Design: levels glioma tissue/cerebral spinal fluid (CSF) were compared between different grades patients. Survival data analyzed with Kaplan–Meier determine the prognostic value B7-H4. Cytokines from CD133+ cells stimulate expression on human macrophages (Mϕs) investigated by FACS, neutralizing antibodies, Transwell...
Aim: Sirtuin3 (sirt3) plays a pivotal role in improving oxidative stress and mitochondrial dysfunction which directly induced neuronal apoptosis after intracerebral hemorrhage (ICH). Reactive oxygen species (ROS) is also critical activator triggering NACHT, LRR, PYD domains-containing protein 3 (NLRP3) inflammasomes activation can regulate inflammatory responses brain. Moreover, hyperglycemia aggravate the ICH-induced damage. Hence, this study was designed to investigate mechanisms of...
Abstract The hippocampus is a key brain region regulating complex cognitive and emotional responses, implicated in the etiology of depressive anxiety disorders, many which exhibit some degree sex difference. male rat consistently reported to be slightly but significantly larger than female. majority studies on development volumetric differences have focused effects estradiol (E 2 ), with relatively few focusing androgens. We examined impact both E androgens newly born cells developing...
Oxidative stress and neuronal apoptosis have been demonstrated to be key features in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Previous studies indicated that Mas receptor activation initiates an anti-oxidative anti-apoptotic role the brain. However, whether can attenuate oxidative SAH remains unknown. To investigate beneficial effect of on induced by SAH, a total 196 rats were subjected endovascular perforation model SAH. AVE 0991 (AVE), selective agonist Mas, was...
A series of drained tests for sands with inherent fabric anisotropy were conducted an automatic hollow cylinder apparatus. The samples subjected to cyclic rotation principal stress axes while the magnitudes effective stresses maintained constant. evolution strain components and volumetric number cycles, relationship between shear components, flow rule investigated. It is found that plastic deformation induced due axes' alone without variation in stresses. contractive accumulates steadily...
Hemorrhagic stroke is a life-threatening neurological disease characterized by high mortality and morbidity. Various pathophysiological responses are initiated after blood enters the interstitial space of brain, compressing brain tissue, thus causing cell death. Recently, three new programmed deaths (PCDs), necroptosis, pyroptosis, ferroptosis, were also found to be important contributors in pathophysiology hemorrhagic stroke. Additionally, blood-brain barrier (BBB) dysfunction plays crucial...
Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury (EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of melanocortin 1 receptor (MC1R), using BMS-470539, attenuates EBI by controlling mitochondrial metabolism after SAH. Methods: We utilized MSG-606, selisistat, PGC-1α verify the neuroprotective effects MC1R. evaluated short- long-term neurobehavior Western blotting, immunofluorescence, Golgi staining techniques...
Microglia play important roles in shaping the developing CNS, and at early stages they have been proposed to regulate progenitor proliferation, differentiation, neuronal survival. However, these studies reveal contradictory outcomes, highlighting complexity of cell–cell interactions. Here, we investigate microglia function during embryonic mouse retina development, where only microglia, progenitors, neurons are present. In both sexes, determine that primarily interact with retinal find...