A5012418279- Neuroinflammation and Neurodegeneration Mechanisms
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Immune cells in cancer
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Retinal Development and Disorders
- Phagocytosis and Immune Regulation
- Complement system in diseases
- Ocular Surface and Contact Lens
- Retinal and Optic Conditions
- Retinopathy of Prematurity Studies
- Ophthalmology and Visual Impairment Studies
- Ocular Infections and Treatments
- Immune Response and Inflammation
- Neurogenesis and neuroplasticity mechanisms
- Nanoparticle-Based Drug Delivery
- Travel-related health issues
- Dental Anxiety and Anesthesia Techniques
- Ocular Diseases and Behçet’s Syndrome
- Ophthalmology and Eye Disorders
- Head and Neck Cancer Studies
- Advanced Cellulose Research Studies
- Cardiac Arrest and Resuscitation
- Systemic Lupus Erythematosus Research
University of Utah
2016-2025
University of California, San Francisco
2024
Aberdeen Royal Infirmary
2024
Orthopaedic Center
2022
Pfizer (United States)
2017-2020
Gonzaga University
2016-2019
McLaughlin Research Institute
2014
University of Arizona
2010
University of South Florida
2009
Princess Alexandra Hospital
2007
Microglia are brain-resident macrophages that shape neural circuit development and implicated in neurodevelopmental diseases. Multiple microglial transcriptional states have been defined, but their functional significance is unclear. Here, we identify a type I interferon (IFN-I)-responsive state the developing somatosensory cortex (postnatal day 5) actively engulfing whole neurons. This population expands during cortical remodeling induced by partial whisker deprivation. Global or...
Dysregulation of the complement system is implicated in neurodegeneration, including human and animal glaucoma. Optic nerve retinal damage glaucoma preceded by local upregulation activation, but whether targeting this early innate immune response could have therapeutic benefit remains undefined. Because signals through three pathways that intersect at C3 here we targeted step to restore balance glaucomatous retina determine its contribution degeneration onset and/or progression. To achieve...
Microglia play important roles in shaping the developing CNS, and at early stages they have been proposed to regulate progenitor proliferation, differentiation, neuronal survival. However, these studies reveal contradictory outcomes, highlighting complexity of cell–cell interactions. Here, we investigate microglia function during embryonic mouse retina development, where only microglia, progenitors, neurons are present. In both sexes, determine that primarily interact with retinal find...
Microglia serve critical remodeling roles that shape the developing nervous system, responding to changing neural environment with phagocytosis or soluble factor secretion. Recent single-cell sequencing (scRNAseq) studies have revealed context-dependent diversity in microglial properties and gene expression, but cues promoting this are not well defined. Here, we ask how interactions apoptotic neurons state, including lysosomal lipid metabolism expression dependence on Colony-stimulating 1...
Objective. The aim of this study was to analyse the prevalence occult destructive arthropathy in subjects with gout and normal plain radiographs by utilizing MRI ultrasound (US). Methods. consisted two visits. At Visit 1, a radiograph 'index joint' obtained. defined as joint that has had most acute attacks historically. index be free erosive damage order for subject qualify 2. 2, an contrast US joint. Each also 'asymptomatic joint'. never experienced attack (determined standard protocol)....
Traditional cellulose nanocrystal (CNC) production methods use harsh chemicals, are energetically expensive, and result in a hydrophilic sulfate surface chemistry with limited utility. Enzymatic of CNCs is less expensive alternative method that eliminates the need for chemicals requires much energy mechanical fibrillation heating. Furthermore, enzymes selectively degrade amorphous regions fibers, do not significantly digest crystalline areas, retain hydroxyl group chemistry. Retention groups...
Microglia have important remodeling functions in neurodevelopment, aging, and disease, with evidence for molecular diversity. However, the signaling pathways environmental cues that drive diverse states of microglia are incompletely understood. We profiled a discrete developing CNS region, murine retina. found distinct transcriptional signatures retinal across development peak postnatal density population resembles aging disease-associated (DAM) CD11c
ABSTRACT Microglia, the parenchymal macrophage of central nervous system, serve crucial remodeling functions throughout development. Microglia are transcriptionally heterogenous, suggesting that distinct microglial states confer discrete roles. Currently, little is known about how dynamic these are, cues promote them, or they impact function. In developing retina, we previously found a significant proportion microglia express CD11c (Integrin αX, Itgax, subunit complement receptor 4) which...
Microglia, the parenchymal macrophage of central nervous system serve crucial remodeling functions throughout development. Microglia are transcriptionally heterogenous, suggesting that distinct microglial states confer discrete roles. Currently, little is known about how dynamic these are, cues promote them, or they impact function. In developing retina, we previously found a significant proportion microglia express CD11c (Integrin αX, complement receptor 4,
Neurodegeneration in glaucoma results decline and loss of retinal ganglion cells (RGCs), is associated with activation myeloid such as microglia macrophages. The chemokine fractalkine (FKN or Cx3cl1) mediates communication from neurons to cells. Signaling through its receptor Cx3cr1 has been implicated multiple neurodegenerative diseases, but the effects on neuronal pathology are variable. Since it unknown how FKN-mediated crosstalk influences RGC degeneration glaucoma, we assessed this a...
The synthesis of ferromagnetic cobalt nanoparticles with polymeric ligands tunable particle size is reported on multi-gram scales. End-functional polystyrene were prepared via atom transfer radical polymerization. Mechanistic studies this system conducted as well direct comparisons polymer vs. small molecule ligand effects nanoparticle formation.
Microglia are brain resident phagocytes that can engulf synaptic components and extracellular matrix as well whole neurons. However, whether there unique molecular mechanisms regulate these distinct phagocytic states is unknown. Here we define a molecularly microglial subset whose function to neurons in the developing brain. We transcriptomically identified cluster of Type I interferon (IFN-I) responsive microglia expanded 20-fold postnatal day 5 somatosensory cortex after partial whisker...
Abstract Background Incidence of Post Endoscopic Retrograde Cholangio-Pancreatography (ERCP) Pancreatitis (PEP) varies between 3.5% and 9.7% as per the 2014 meta-analyses. Our aim was to evaluate incidence, perform a causal analysis gauge financial implications PEP in our hospital for general surgical patients help optimise utilisation resources. Methods All General Surgical who had ERCP 01/10/2022 31/03/2023 were included analysis. A successful defined cannulation biliary tree. The digital...
Half of all newborn neurons in the developing brain are removed via efferocytosis - phagocytic clearance apoptotic cells. Microglia brain-resident professional phagocytes that play important roles neural circuit development including as primary effectors efferocytosis. While mechanisms through which microglia recognize potential cargo widely studied, lysosomal necessary for efficient digestion less well defined. Here we show protease cathepsin B promotes microglial and restricts accumulation...
Cervical cancer remains one of the most preventable yet devastating diseases affecting women worldwide. Despite remarkable advances in prevention and treatment, global burden cervical continues to highlight stark disparities healthcare access, education, resources. As we approach 2050, projections suggest a 40% increase cases globally, underscoring urgent need for coordinated, data-driven interventions.
ABSTRACT Dysregulation of the complement system is implicated in neurodegeneration, including human and animal glaucoma. Optic nerve retinal damage glaucoma preceded by local upregulation activation, but whether targeting this early innate immune response could have therapeutic benefit remains undefined. Because signals through three pathways that intersect at C3 here we targeted step to restore balance glaucomatous retina, determine its contribution degeneration onset and/or progression. To...
Journal Article Imaging of Polyethylene Glycol Layers on Nanoparticles Get access Sarah R Anderson, Anderson Electron Microscopy Laboratory, and Search for other works by this author on: Oxford Academic Google Scholar Mackensie C Smith, Smith Nanotechnology Characterization Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory Frederick, MD 21702 Jeffrey D Clogston, Clogston Anil K Patri, Patri Scott E McNeil, McNeil Ulrich Baxa Microanalysis,...
The mammalian dive response (DR) is described as oxygen-conserving based on measures of bradycardia, peripheral vasoconstriction, and decreased ventilation (V̇ E ). Using a model simulated diving, this study examined the effect nonapnoeic facial submersions (NAFS) oxygen consumption (V̇O 2 19 participants performed four 2-min NAFS with 8 min rest between each. Two were in 5 °C water, 25 water. Heart rate (HR) was collected using chest strap monitors. A tube connected to inspired port...