A5053278255- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Ophthalmology and Eye Disorders
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Advanced Fluorescence Microscopy Techniques
- Cerebral Venous Sinus Thrombosis
- Glaucoma and retinal disorders
- Immune Response and Inflammation
- Angiogenesis and VEGF in Cancer
- Adenosine and Purinergic Signaling
- Retinal Development and Disorders
- Cell Image Analysis Techniques
- Retinal Diseases and Treatments
University of Utah
2022-2025
Microglia serve critical remodeling roles that shape the developing nervous system, responding to changing neural environment with phagocytosis or soluble factor secretion. Recent single-cell sequencing (scRNAseq) studies have revealed context-dependent diversity in microglial properties and gene expression, but cues promoting this are not well defined. Here, we ask how interactions apoptotic neurons state, including lysosomal lipid metabolism expression dependence on Colony-stimulating 1...
Transitions in competence underlie the ability of CNS progenitors to generate a diversity neurons and glia. Retinal progenitor cells mouse early-born cell types embryonically late-born largely postnatally. We find that transition from early late is regulated by Jarid2. Loss Jarid2 results extended production expression genes. can regulate histone modifications, we reduction repressive mark H3K27me3 on subset genes with loss Jarid2, most notably Foxp1. show Foxp1 regulates retinal types,...
ABSTRACT Microglia, the parenchymal macrophage of central nervous system, serve crucial remodeling functions throughout development. Microglia are transcriptionally heterogenous, suggesting that distinct microglial states confer discrete roles. Currently, little is known about how dynamic these are, cues promote them, or they impact function. In developing retina, we previously found a significant proportion microglia express CD11c (Integrin αX, Itgax, subunit complement receptor 4) which...
Microglia, the parenchymal macrophage of central nervous system serve crucial remodeling functions throughout development. Microglia are transcriptionally heterogenous, suggesting that distinct microglial states confer discrete roles. Currently, little is known about how dynamic these are, cues promote them, or they impact function. In developing retina, we previously found a significant proportion microglia express CD11c (Integrin αX, complement receptor 4,
Abstract Microglia serve critical remodeling roles that shape the developing nervous system, responding to changing neural environment with phagocytosis or soluble factor secretion. Recent single-cell sequencing (scRNAseq) studies have revealed context-dependent diversity in microglial properties and gene expression, but cues promoting this are not well defined. Here, we ask how interactions apoptotic neurons state, including lysosomal lipid metabolism expression independence from...