A5007101254- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Biochemical effects in animals
- Diet and metabolism studies
- Phagocytosis and Immune Regulation
- Sirtuins and Resveratrol in Medicine
- Retinal Diseases and Treatments
- Mitochondrial Function and Pathology
- Adenosine and Purinergic Signaling
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Immune Response and Inflammation
University of Utah
2022-2025
National Institute on Aging
2018-2022
Institute on Aging
2019-2020
National Institutes of Health
2019
Impaired mitochondrial function and aberrant neuronal network activity are believed to be early events in the pathogenesis of Alzheimer's disease (AD), but how alterations contribute circuits is unknown. In this study, we examined protein deacetylase sirtuin 3 (SIRT3) AD. Compared with AppPs1 mice, Sirt3-haploinsufficient mice (Sirt3 +/− AppPs1) exhibit epileptiform EEG seizure. Both male female Sirt3 were observed die prematurely before 5 months age. When comparing among different...
Microglia serve critical remodeling roles that shape the developing nervous system, responding to changing neural environment with phagocytosis or soluble factor secretion. Recent single-cell sequencing (scRNAseq) studies have revealed context-dependent diversity in microglial properties and gene expression, but cues promoting this are not well defined. Here, we ask how interactions apoptotic neurons state, including lysosomal lipid metabolism expression dependence on Colony-stimulating 1...
ABSTRACT Microglia, the parenchymal macrophage of central nervous system, serve crucial remodeling functions throughout development. Microglia are transcriptionally heterogenous, suggesting that distinct microglial states confer discrete roles. Currently, little is known about how dynamic these are, cues promote them, or they impact function. In developing retina, we previously found a significant proportion microglia express CD11c (Integrin αX, Itgax, subunit complement receptor 4) which...
Microglia, the parenchymal macrophage of central nervous system serve crucial remodeling functions throughout development. Microglia are transcriptionally heterogenous, suggesting that distinct microglial states confer discrete roles. Currently, little is known about how dynamic these are, cues promote them, or they impact function. In developing retina, we previously found a significant proportion microglia express CD11c (Integrin αX, complement receptor 4,