A5043522586- Neuroinflammation and Neurodegeneration Mechanisms
- Malaria Research and Control
- Immune cells in cancer
- Mosquito-borne diseases and control
- Phagocytosis and Immune Regulation
- Retinal Development and Disorders
- Complement system in diseases
- Parasitic Infections and Diagnostics
- Poverty, Education, and Child Welfare
- Fecal contamination and water quality
- Glaucoma and retinal disorders
- Library Science and Information Literacy
- Immune Response and Inflammation
- Retinal Diseases and Treatments
- Web and Library Services
- Family and Disability Support Research
- Adenosine and Purinergic Signaling
- Dermatological diseases and infestations
- Pluripotent Stem Cells Research
- Child Nutrition and Water Access
- Axon Guidance and Neuronal Signaling
- Genetics and Neurodevelopmental Disorders
- HIV/AIDS Research and Interventions
- Retinopathy of Prematurity Studies
- CRISPR and Genetic Engineering
University of Utah
2018-2025
Universidade Federal do Rio de Janeiro
2025
University of California, Santa Cruz
2013-2021
Centers for Disease Control and Prevention
1996-2008
National Center for Emerging and Zoonotic Infectious Diseases
2008
Centers for Disease Control and Prevention
2007
National Center for Infectious Diseases
1996-2006
Severn Trent (United Kingdom)
1993-1998
University of Malawi
1996
Ministry of Health
1996
Microglia serve critical remodeling roles that shape the developing nervous system, responding to changing neural environment with phagocytosis or soluble factor secretion. Recent single-cell sequencing (scRNAseq) studies have revealed context-dependent diversity in microglial properties and gene expression, but cues promoting this are not well defined. Here, we ask how interactions apoptotic neurons state, including lysosomal lipid metabolism expression dependence on Colony-stimulating 1...
Microglia have important remodeling functions in neurodevelopment, aging, and disease, with evidence for molecular diversity. However, the signaling pathways environmental cues that drive diverse states of microglia are incompletely understood. We profiled a discrete developing CNS region, murine retina. found distinct transcriptional signatures retinal across development peak postnatal density population resembles aging disease-associated (DAM) CD11c
We have characterized the natural immune responses to 19-kDa domain of merozoite surface protein 1 in individuals from an area western Kenya which malaria is holoendemic. used three known variant forms yeast-expressed recombinant fragment that are referred as E-KNG, Q-KNG, and E-TSR antigens. T-cell proliferative older than 15 years profile immunoglobulin G (IgG) antibody isotypes 2 74 old were determined. Positive Q-KNG antigen observed for 54% individuals, 37 35% responded E-KNG...
Despite international recommendations to use malaria treatment and prevention in pregnant women malaria-endemic areas, few studies have evaluated the efficacy of available antimalarial regimens. This issue is particular concern face spreading chloroquine (CQ)-resistance Plasmodium falciparum malarious areas sub-Saharan Africa. In a prospective trial rural Malawian women, we examined three regimens using CQ (including existing national policy regimen) one regimen mefloquine (MQ). The was...
Transitions in competence underlie the ability of CNS progenitors to generate a diversity neurons and glia. Retinal progenitor cells mouse early-born cell types embryonically late-born largely postnatally. We find that transition from early late is regulated by Jarid2. Loss Jarid2 results extended production expression genes. can regulate histone modifications, we reduction repressive mark H3K27me3 on subset genes with loss Jarid2, most notably Foxp1. show Foxp1 regulates retinal types,...
ABSTRACT Microglia, the parenchymal macrophage of central nervous system, serve crucial remodeling functions throughout development. Microglia are transcriptionally heterogenous, suggesting that distinct microglial states confer discrete roles. Currently, little is known about how dynamic these are, cues promote them, or they impact function. In developing retina, we previously found a significant proportion microglia express CD11c (Integrin αX, Itgax, subunit complement receptor 4) which...
Retinal ganglion cells (RGCs) are the projection neurons of retina, and their death promotes an irreversible blindness. Several factors were described to control genesis during retinal development which include Atoh7 as a major orchestrator for RGC program downstream targets, including Pou4f factors, in turn regulate key aspects terminal differentiation. The absence POU4F family genes results defects differentiation, aberrant axonal elaboration ultimately death, confirming requirement...
In vitro studies have shown that inhibition of Plasmodium falciparum blood-stage parasite growth by antibody-dependent cellular is mediated cooperation between malaria-specific IgG1 and IgG3, but not IgG2, monocytes via the Fcγ receptor II (FcγRII). A single amino acid substitution at position 131 in FcγRIIa critical binding human IgG subclasses. The hypothesis FcγRIIa-Arg/Arg131 genotype, which does bind to a host genetic factor for protection against high-density P. infection was tested....
Microglia, the parenchymal macrophage of central nervous system serve crucial remodeling functions throughout development. Microglia are transcriptionally heterogenous, suggesting that distinct microglial states confer discrete roles. Currently, little is known about how dynamic these are, cues promote them, or they impact function. In developing retina, we previously found a significant proportion microglia express CD11c (Integrin αX, complement receptor 4,
Two hundred eleven adults with human immunodeficiency virus (HIV) infection hospitalized for community-acquired pneumonia, including Pneumocystis carinii pneumonia (PCP; patients), and 192 matched HIV-infected patients without (controls) were interviewed to determine risk factors pneumonia. Multivariate logistic regression showed that less likely than controls have used trimethoprim-sulfamethox-azole (TMP-SMZ) prophylaxis (odds ratio [OR], 0.22; 95% confidence interval [CI], 0.12–0.41) more...
We investigated the development and maintenance of proliferative antibody responses to apical membrane antigen-1 (AMA-1) epitopes in a holoendemic area western Kenya. Young children (< 10 years), older (10-17 adults (> or = 18 years) were followed longitudinally for T-cell at 3 time points with an interval 3-4 months. The against AMA-1 T (PL171, PL172, PL173, PL186, PL191, PL192) not stable during follow-up; however, response mycobacterial antigen PPD was highly stable. responder...
Alternative splicing of pre-mRNAs can rapidly regulate the expression large groups proteins. The RNA binding protein TRA2B (SFRS10) plays well-established roles in developmentally regulated alternative during Drosophila sexual differentiation. is also essential for mammalian embryogenesis and implicated numerous human diseases. Precise regulation critical to development function central nervous system; however, requirements specific factors neurogenesis are poorly understood. This study...
Abstract Six mosquito species were identified in a survey of containers associated with 347 households four villages American Samoa. Aedes polynesiensis Marks (Diptera: Culicidae) and aegypti (L) the most abundant species, representing 57% 29% mosquitoes identified. Culex quinquefasciatus (Say), annulirostris (Skuse) , oceanicus (Belkin) Toxorhynchites amboinensis (Doleschall) also found. Ae. showed distinct differences their use containers, preferring large small respectively. By contrast...
Summary A systematic, random sample of 450 small and mixed-animal practitioners was selected from the client list a prominent veterinary pharmaceutical animal health company. telephone survey conducted, using standard questionnaire, to assess whether current practices concerning prophylaxis treatment canine roundworm ( Toxocara canis ) hookworm Ancylostoma spp) infections are adequate prevent transmission human beings. Analysis results focused on 3 questions related prevention:...
ABSTRACT Retinal ganglion cells (RGCs) are the projection neurons of retina. In early retinal progenitor (RPCs), Atoh7 orchestrates developmental RGC program and regulates expression critical downstream targets, including Pou4f factors. The absence Pou4f2 or more POU4F family genes results in defects differentiation, aberrant axonal elaboration ultimately death, confirming requirement factors for development survival, with a role regulating axon outgrowth pathfinding. Here, we investigated...
A novel filter system comprising open cell reticulated foam rings compressed between retaining plates and fitted into a filtration housing was evaluated for the recovery of oocysts Cryptosporidium from water. Mean recoveries 90.2% seeded small large volume (100-2000 l) tap water samples, 88.8% 10-20 l river were achieved. Following simple potassium citrate flotation concentrate clean-up procedure, mean 56.7% samples 60.9% samples. This represents marked improvement in capture compared with...
Recovery of oocysts Cryptosporidium parvum using 142 mm diameter 1.2 μm pore size acrylic copolymer membrane filters was evaluated. A mean recovery efficiency 25.5% for oocyst concentrations about 200 in 10 1 achieved, making this method a simple and relatively efficient procedure compared with current standard methods.
Abstract We present a mosquito marking technique suitable for mark‐release‐recapture that can be used with hand‐held, portable X‐ray fluorescence (XRF) spectrometer, which is practical field measurements. Third instar Anopheles gambiae Giles sensu stricto (Diptera: Culicidae) and stephensi Liston larvae were cultured to pupation in water containing rubidium (Rb) Cl at concentrations up 1000 p.p.m. Rb. survived adulthood as high Rb but suffered pupal mortality reduced adult longevity...
The relationship between mosquito 4th instar larval desiccation and survival to adulthood was explored by three methods in the laboratory. Two colonies of Anopheles arabiensis one gambiae were studied. We found significant differences tolerance among all stocks suggesting an intra- interspecific genetic component tolerance. An. KGB, originating from Zimbabwe about 1975, had a much-reduced compared G3, colonized Gambia DONGOLA which originated Sudan 2004. Individuals G3 stock survived times...
A lack of knowledge among university faculty members the services their libraries provide is a growing concern in librarianship. Poor communication and inadequate interaction between library, library′s failure to apply marketing strategies promote its are foremost factors contributing this condition. In order analyse situation within context University West Indies survey was conducted. questionnaire administered random sample 150 six faculties on Mona Campus, Jamaica. The findings revealed...
To evaluate the ability of antibodies to Plasmodium falciparum ring-infected erythrocyte surface antigen (Pf155/RESA) epitopes discriminate between individuals well protected or poorly against malaria, a receiver operating characteristic analysis was performed in two populations living Madagascar and Malawi. The definition protection based on longitudinal measurements clinical malarial attacks during season high malaria transmission study, cross-sectional measurement parasitemia Malawi...