A5070445483- Retinal Development and Disorders
- Developmental Biology and Gene Regulation
- Innovations in Medical Education
- Axon Guidance and Neuronal Signaling
- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Wnt/β-catenin signaling in development and cancer
- Hippo pathway signaling and YAP/TAZ
- Clinical Reasoning and Diagnostic Skills
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neural Engineering
- Congenital heart defects research
- Microbial Metabolic Engineering and Bioproduction
- Plant biochemistry and biosynthesis
- Cancer-related Molecular Pathways
- Zebrafish Biomedical Research Applications
- Genetics and Neurodevelopmental Disorders
- Retinoids in leukemia and cellular processes
- Neuroscience and Neuropharmacology Research
- Plant Gene Expression Analysis
- Evaluation of Teaching Practices
- Education, Achievement, and Giftedness
- Kruppel-like factors research
- Metabolism and Genetic Disorders
- Anatomy and Medical Technology
University of Utah
2011-2024
University of Cincinnati
2008
George Washington University
1999-2004
Washington University Medical Center
1999-2004
University of Arizona
1993-1994
To examine the effect of apolipoprotein E (APOE) alleles on age-related macular degeneration (AMD) risk and age at diagnosis AMD in a large patient cohort recruited from single center.The frequency APOE was analyzed 632 unrelated patients 206 controls, all whom were white ancestry. The presence or absence disease symptoms controls based clinical examination and/or ophthalmic records. association with explored context subtypes, family history status, possible interaction smoking, distribution...
The design and characteristics of a video-based device that can noninvasively measure the extent rate shortening isolated cardiac myocytes are discussed. Construction motion detector is relatively inexpensive. It easy to use because edge selection simple video images contracting cells be analyzed at experimenter's convenience. also exhibits high spatial adequate temporal resolution. physiologic application was examined by measuring overall in enzymatically dispersed adult guinea pig rabbit...
Progenitor cells in the central nervous system must leave cell cycle to become neurons and glia, but signals that coordinate this transition remain largely unknown. We previously found Wnt signaling, acting through Sox2, promotes neural competence Xenopus retina by activating proneural gene expression. now report Sox2 inhibit differentiation Notch activation. Independently of stimulates retinal progenitor proliferation this, when combined with block on differentiation, maintains fates....
The Wnt/frizzled cell signaling pathway has been implicated in the determination of polarity a number systems, including Drosophila retina. vertebrate retina develops from an undifferentiated neuroepithelium into organized and laminated structure that demonstrates high degree at both tissue cellular levels. In process searching for molecules are preferentially expressed by retinal pigment epithelium (RPE), we identified secreted frizzled-related protein 5 (SFRP5), member SFRP family appears...
The histone methyltransferase complex PRC2 controls key steps in developmental transitions and cell fate choices; however, its roles vertebrate eye development remain unknown. Here, we report that Xenopus, regulates the progression of retinal progenitors from proliferation to differentiation. We show core components are enriched downregulated differentiated cells. Knockdown component Ezh2 leads reduced progenitor proliferation, part due upregulation Cdk inhibitor p15Ink4b. In addition,...
In a wide range of vertebrate species, the bHLH transcription factor Ath5 is tightly associated with both initiation neurogenesis in retina and genesis retinal ganglion cells. Here, we describe at least two modes regulating expression during development. We have found that proximal cis-regulatory region Xenopus gene (Xath5) highly conserved across species sufficient to drive retinal-specific reporter transgenic embryos. Xath5 transgene depended upon binding sites (E-boxes) as well activity...
Many isoprenoid compounds are necessary for growth and development of the seed seedling. The first committed step in biosynthesis is conversion 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate. This study shows that specific activity rate-limiting enzyme, reductase (HMGR) developmentally regulated during Zea mays seedling emergence. highest activities were observed stages rapid mitotic divisions: 10 12 d after pollination endosperm (216.1 units) embryo (140.2 units). During maturation,...
Problem: Traditionally, journal editors expect individuals to complete peer reviews of submitted manuscripts on their own. Recently, a number health sciences journals have begun support, and even espouse, the practice group review (GPR). With GPR, multiple work together with permission from editor. Motivated by idea that GPR could provide meaningful service learning experience for participants in an interprofessional educational scholarship course, we conducted three such subsequently...
Abstract The two paralogues of the Xenopus flotillin1 gene ( flotillin1A and flotillin1B ), which encodes a putative membrane‐associated protein, were cloned from egg, cleavage, tadpole cDNA libraries. Both mRNAs are present during oogenesis cleavage stages. After onset zygotic transcription, transcripts first expressed throughout embryonic ectoderm become enhanced in presumptive neural as plate forms. As tube forms differentiates, enriched dorsal half, with particularly high expression...
Introduction Reviewing elements of a curriculum, such as courses and clerkships in medical school, is an essential part the quality improvement process. Yet there gap literature t...
During seed maturation the levels of rate-limiting enzyme isoprenoid biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) decrease while compund abscisic acid (ABA) increase. In present study, we demonstrate that HMGR specific activity is inversely correlated with endogenous ABA in Zea mays endosperm during development. and were measured maize vivipary mutuants vp2, vp5, vp7, which are defective vp1, an response element. Reduced observed whereas higher compared wild-type...
A plunge electrode is made from a hypodermic needle with one side cut open and multiple electrodes exposed tip to base. method for constructing chlorided silver needles explained, problems associated chloriding are pointed out. The small surface area of these makes empirical methods difficult use. monitor the testing twelve-electrode was constructed. This system continuously measures impedance during chloriding.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Using pass/fail (P/F) course grades may motivate students to perform well enough earn a passing grade, giving them false sense of competence and not motivating remediate deficiencies. The authors explored whether adding yet pass (NYP) grade P/F scale would promote students' mastery orientation toward learning.The captured student outcomes data on time cost implementing the NYP in 2021 at University Utah School Medicine. One cohort medical students, who had experienced both P/NYP/F scales...