A5000946736- Retinal Development and Disorders
- Developmental Biology and Gene Regulation
- Axon Guidance and Neuronal Signaling
- Zebrafish Biomedical Research Applications
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Neurobiology and Insect Physiology Research
- Food Security and Health in Diverse Populations
- Pluripotent Stem Cells Research
- Hedgehog Signaling Pathway Studies
- Cellular Mechanics and Interactions
- School Health and Nursing Education
- Smoking Behavior and Cessation
- Injury Epidemiology and Prevention
- Microtubule and mitosis dynamics
- Hippo pathway signaling and YAP/TAZ
- Cellular transport and secretion
- RNA Research and Splicing
- Plant and Biological Electrophysiology Studies
- Olfactory and Sensory Function Studies
- Cancer, Hypoxia, and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Sperm and Testicular Function
National Center for Chronic Disease Prevention and Health Promotion
1995-2024
Centers for Disease Control and Prevention
1995-2024
National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention
2016-2024
University of Cambridge
2012-2023
Carl Zeiss (United States)
2019
Emory University
2017
The University of Texas Medical Branch at Galveston
1979-2015
Bridge University
2013
CoxHealth
2012
Oak Ridge National Laboratory
2005-2007
Health-risk behaviors contribute to the leading causes of morbidity and mortality among youth adults in United States. In addition, significant health disparities exist demographic subgroups defined by sex, race/ethnicity, grade school between sexual minority nonsexual youth. Population-based data on most important health-related at national, state, local levels can be used help monitor effectiveness public interventions designed protect promote levels.
Priority health-risk behaviors contribute to the leading causes of morbidity and mortality among youth adults. Population-based data on these at national, state, local levels can help monitor effectiveness public health interventions designed protect promote nationwide.September 2014-December 2015.The Youth Risk Behavior Surveillance System (YRBSS) monitors six categories priority young adults: 1) that unintentional injuries violence; 2) tobacco use; 3) alcohol other drug 4) sexual related...
Priority health-risk behaviors, which are behaviors that contribute to the leading causes of morbidity and mortality among youth adults, often established during childhood adolescence, extend into adulthood, interrelated preventable.September 2010-December 2011.The Youth Risk Behavior Surveillance System (YRBSS) monitors six categories priority young adults: 1) unintentional injuries violence; 2) tobacco use; 3) alcohol other drug 4) sexual unintended pregnancy sexually transmitted diseases...
ABSTRACT: Priority health‐risk behaviors that contribute to the leading causes of mortality, morbidity, and social problems among youth adults often are established during youth, extend into adulthood, interrelated. The Youth Risk Behavior Surveillance System (YRBSS) monitors six categories priority young adults: unintentional intentional injuries, tobacco use, alcohol other drug sexual behaviors, unhealthy dietary physical inactivity. YRBSS includes both a national school‐based survey...
Populations of Drosophila were trained by alternately exposing them to two odorants, one coupled with electric shock. On testing, the flies avoided shock-associated odor. Pseudoconditioning, excitatory states, odor preference, sensitization, habituation, and subjective bias have been eliminated as explanations. The selective avoidance can be extinguished retraining. All in population equal probability expressing this behavior. Memory persists for 24 hr. Another paradigm has developed which...
Several eye-field transcription factors (EFTFs) are expressed in the anterior region of vertebrate neural plate and essential for eye formation. The Xenopus EFTFs ET, Rx1, Pax6, Six3, Lhx2, tll Optx2 a dynamic, overlapping pattern presumptive field. Expression an EFTF cocktail with Otx2 is sufficient to induce ectopic eyes outside nervous system at high frequency. Using both subsets functional (inductive) analysis individual EFTFs, we have revealed genetic network regulating field...
Sexual identity and sex of sexual contacts can both be used to identify minority youth. Significant health disparities exist between nonsexual However, not enough is known about health-related behaviors that contribute negative outcomes among youth how the prevalence these compare with minorities.September 2014-December 2015.The Youth Risk Behavior Surveillance System (YRBSS) monitors six categories priority young adults: 1) unintentional injuries violence; 2) tobacco use; 3) alcohol other...
We examined optokinetic and optomotor responses of 450 zebrafish mutants, which were isolated previously based on defects in organ formation, tissue patterning, pigmentation, axon guidance, or other visible phenotypes. These strains carry single point mutations >400 essential loci. asked fraction the mutants develop blindness types impairments specific to visual system. Twelve failed respond either one both our assays. Subsequent histological electroretinographic analysis revealed unique...
Three mutations which eliminate specific types of photoreceptors in Drosophila were characterized. Of the eight each facet, two delete outer six (R 1-6). The third eliminates R 7, one central photoreceptors. Double mutants can be constructed only photoreceptor 8 is present. spectral sensitivities, photopigments, and behavioural properties these investigated. 1-6 have sensitivity peaks, near 350 470 nm. These receptors contain a rhodopsin with absorption peaks. It interconverts metarhodopsin...
Local translation regulates the axonal proteome, playing an important role in neuronal wiring and axon maintenance. How mRNAs are localized to specific subcellular sites for translation, however, is not understood. Here we report that RNA granules associate with endosomes along axons of retinal ganglion cells. RNA-bearing Rab7a late also ribosomes, real-time imaging reveals they local protein synthesis. We show often pause on mitochondria encoding proteins mitochondrial function translated...
A fundamental question in developmental neuroscience is how a collection of progenitor cells proliferates and differentiates to create brain the appropriate size cellular composition. To address this issue, we devised lineage-tracing assays developing zebrafish embryos reconstruct entire retinal lineage progressions vivo thereby provide complete quantitative map generation vertebrate CNS tissue from individual progenitors. These data are consistent with simple model which retina derived set...
The Youth Risk Behavior Surveillance System (YRBSS) is the largest public health surveillance system in United States, monitoring a broad range of health-related behaviors among high school students. includes nationally representative Survey (YRBS) and separate school-based YRBSs conducted by states, tribes, territories, local districts. In 2021, these surveys were during COVID-19 pandemic. pandemic underscored importance data understanding changes youth risk addressing multifaceted needs...
ABSTRACT Time-lapse video recordings were made of individual retinal ganglion cell fibres growing to and terminating in the optic tectum Xenopus embryos. The stained by inserting a crystal lipophilic fluorescent dye, Dil, into developing retina. Growth cones observed tract using 20 ms flashes light induce fluorescence approximately once every minute. Fluorescent images captured with SIT camera, processed saved on time-lapse recorder. main conclusions from observing normal are as follows. (1)...
During the development of a vertebrate embryo, cell fate is determined by inductive signals passing between neighboring tissues. Such determinative interactions have been difficult to characterize fully without knowledge molecular mechanisms involved. Mutations Drosophila and nematode Caenorhabditis elegans isolated that define family related gene products involved in similar types cellular inductions. One these genes, Notch from Drosophila, with choices neurogenic region blastoderm,...
Abstract Two cell autonomous fluorescent labels (DiI and Hoechst) were used as vital markers in a fate map study of the Xenopus neural plate ridge. Most areas brain derive from that is consistent with topology sheet rolling into tube, i.e., neighboring are maintained neighbors. This has enabled us not only to plot fates larval structures, but also suggest their primordial orientation plate. Since overlapping gave rise regions central nervous system (CNS), we have been able construct...