A5043843718- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune cells in cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Acute Ischemic Stroke Management
- Autophagy in Disease and Therapy
- Intracranial Aneurysms: Treatment and Complications
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Tryptophan and brain disorders
- Phagocytosis and Immune Regulation
- Meningioma and schwannoma management
- Alzheimer's disease research and treatments
- Endometriosis Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Anesthesia and Neurotoxicity Research
- S100 Proteins and Annexins
- Hydrogen's biological and therapeutic effects
- Neurogenesis and neuroplasticity mechanisms
- Apelin-related biomedical research
Second Affiliated Hospital of Zhejiang University
2016-2025
Tongji University
2024
Tongji Hospital
2024
Department of Embryology
2023-2024
Carnegie Institution for Science
2023-2024
Zhejiang University
2013-2023
Chinese Institute for Brain Research
2023
Indiana University School of Medicine
2019
Amway (United States)
2018-2019
Hangzhou Academy of Agricultural Sciences
2019
Abstract Background Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Microglial/macrophage activation neuroinflammation are key cellular events following TBI, but the regulatory functional mechanisms still not well understood. Myeloid-epithelial-reproductive tyrosine kinase (Mer), member Tyro-Axl-Mer (TAM) family receptor kinases, regulates multiple features microglial/macrophage physiology. However, its function in regulating innate immune response M1/M2...
Neuroinflammation and oxidative stress play important roles in early brain injury following subarachnoid hemorrhage (SAH). This study is the first to show that activation of apelin receptor (APJ) by apelin-13 could reduce endoplasmic reticulum (ER)-stress-associated inflammation after SAH.Apelin-13, siRNA, APJ adenosine monophosphate-activated protein kinase (AMPK) inhibitor-dorsomorphin were used investigate if provide neuroprotective effects SAH. Brain water content, neurological...
Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury (EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of melanocortin 1 receptor (MC1R), using BMS-470539, attenuates EBI by controlling mitochondrial metabolism after SAH. Methods: We utilized MSG-606, selisistat, PGC-1α verify the neuroprotective effects MC1R. evaluated short- long-term neurobehavior Western blotting, immunofluorescence, Golgi staining techniques...
The field of nutrition has evolved rapidly over the past century. Nutrition scientists and policy makers in developed world have shifted focus their efforts from dealing with diseases overt nutrient deficiency to a new paradigm aimed at coping conditions excess-calories, sedentary lifestyles stress. Advances science, technology manufacturing largely eradicated diseases, while simultaneously facing growing challenges obesity, non-communicable aging. research gone through necessary evolution,...
Hemorrhagic stroke is a life-threatening neurological disease characterized by high mortality and morbidity. Various pathophysiological responses are initiated after blood enters the interstitial space of brain, compressing brain tissue, thus causing cell death. Recently, three new programmed deaths (PCDs), necroptosis, pyroptosis, ferroptosis, were also found to be important contributors in pathophysiology hemorrhagic stroke. Additionally, blood-brain barrier (BBB) dysfunction plays crucial...
Acute central nervous system (CNS) injuries, such as stroke, traumatic brain injury, and spinal cord injury present a grave health care challenge worldwide due to high morbidity mortality, well limited clinical therapeutic strategies. Established literature has shown that oxidative stress, inflammation, excitotoxicity, apoptosis play important roles in the pathophysiological processes of acute CNS injuries. Recently, there have been many studies on topic ferroptosis, form regulated cell...
Abstract Background Endometriosis is an oestrogen-dependent disease with unclear aetiology and pathogenesis affecting 6–10% of the global female population, predominantly those reproductive age. Herein, we profile transcriptomes approximately 55,000 single cells from three groups including ectopic endometrium, eutopic endometrium women endometriosis, healthy to create a single-cell transcriptome atlas endometriosis. Results We have identified 9 cell types performed analysis fibroblasts,...