A5100638845- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Estrogen and related hormone effects
- Protein Tyrosine Phosphatases
- Pregnancy-related medical research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer-related molecular mechanisms research
- Maternal and fetal healthcare
- MicroRNA in disease regulation
- Ectopic Pregnancy Diagnosis and Management
- Intestinal and Peritoneal Adhesions
- Ion Transport and Channel Regulation
- RNA Research and Splicing
- Omental and Epiploic Conditions
- Neuroblastoma Research and Treatments
- Gestational Trophoblastic Disease Studies
- Galectins and Cancer Biology
- Nitrogen and Sulfur Effects on Brassica
- Indoor Air Quality and Microbial Exposure
- Advanced Breast Cancer Therapies
- Whipple's Disease and Interleukins
- Cancer Treatment and Pharmacology
Fujian Medical University
2019-2024
Union Hospital
2024
Women's Hospital, School of Medicine, Zhejiang University
2014-2023
First Affiliated Hospital of Fujian Medical University
2023
Zhejiang University
2005-2015
Tri-Service General Hospital
2006
Shanghai Medical College of Fudan University
1997-2000
Icahn School of Medicine at Mount Sinai
1998
University of Minnesota
1995
Abstract Background Endometriosis is an oestrogen-dependent disease with unclear aetiology and pathogenesis affecting 6–10% of the global female population, predominantly those reproductive age. Herein, we profile transcriptomes approximately 55,000 single cells from three groups including ectopic endometrium, eutopic endometrium women endometriosis, healthy to create a single-cell transcriptome atlas endometriosis. Results We have identified 9 cell types performed analysis fibroblasts,...
This prospective study aimed to determine whether patients with endometriosis are having different level of interlukin‐17 (IL‐17) in peritoneal fluid when compared without endometriosis. The minimal/mild had a significantly higher IL‐17 those moderate/severe or concentration was and infertility coexist. However, the did not correlate phase menstrual cycle Our suggested that might play an important role pathogenesis early endometriosis‐associated infertility.
Although associations of interleukin-10 (IL-10) gene promoter polymorphisms and their protein production with endometriosis risk have been reported, the correlations remain controversial. The objective this study was to determine IL-10 at -1082, -819 -592 sites in peritoneal fluid (PF) patients without endometriosis. -1082 site were detected by amplification refractory mutation system (ARMS)–PCR that genotyped restriction fragment length polymorphism (RFLP)-PCR. Protein levels PF measured...
Background: To compare clinicopathologic, molecular features, and treatment outcome between fumarate hydratase-deficient renal cell carcinoma (FH-dRCC) type 2 papillary (T2 pRCC). Methods: Data of T2 pRCC patients FH-dRCC with additional next-generation sequencing information were retrospectively analyzed. The cancer-specific survival (CSS) disease-free (DFS) primary endpoint. Results: A combination FH 2-succino-cysteine (2-SC) increased the rate negative predictive value FH-dRCC. Compared...
Aquaporin 5 (AQP5) participates in the migration of endometrial cells. Elucidation molecular mechanisms associated with AQP5-mediated, cells may contribute to a better understanding endometriosis. Our objectives included identifying estrogen-response element (ERE) promoter region AQP5 gene, and, investigating effects on ectopic implantation Luciferase reporter assays and electrophoretic mobility shift assay (EMSA) identified ERE-like motif gene. After blocking up-regulating estradiol (E2)...
Is phosphatase of regenerating liver-3 (PRL-3) associated with increased motility endometriotic cells from endometrioma?Elevated PRL-3 promotes cytoskeleton reorganization, cell migration and invasion endometrial stromal (ESCs) endometrioma.Overexpression is cancer migration, metastatic phenotype.Primary human ESCs were isolated eutopic endometrium women without endometriosis (EuCo, n = 10), histologically proven endometrioma (EuEM, 19) the cyst wall ovarian (OvEM, 26).The expression in...
The risk of endometriosis (EM), which is a common complex gynaecological disease, related to genetic predisposition. However, it unclear how variants confer the EM. Here, via Sherlock integrative analysis, we combined large-scale genome-wide association studies (GWAS) summary statistics on EM (N = 245,494) with blood-based eQTL dataset 1,490) identify risk-related genes. For validation, leveraged two independent datasets 769) for integration GWAS data. Thus, prioritised 14 genes, including...
Aquaporin (AQP)-dependent cell migration has broad implications in angiogenesis, tumor metastasis, wound healing, glial scarring and other events requiring movement. There are 13 isoforms of AQP (0-12) that have been identified mammals. It is unclear whether AQP5 plays a role the development endometrial cancer. We recently demonstrated ovarian steroids may affect expression female genital tract. In this study, we considered Ishikawa cells, an adenocarcinoma line derived from endometrium. The...
This study aims to explore the feasibility of a hysteroscopic procedure combined with progestin therapy in young patients stage Ia endometrioid carcinoma (EC) avoid sterilization.Eleven women EC (International Federation Gynecology and Obstetrics grade 1) who were treated approach from July 2004 June 2016 retrospectively analyzed followed up monitor their general recovery pregnancy outcome.The patients' median age was 27.3 years (range, 25-39 years). Comorbidities consisted primary...