A5101913112- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Gynecological conditions and treatments
- Endometrial and Cervical Cancer Treatments
- Estrogen and related hormone effects
- Ectopic Pregnancy Diagnosis and Management
- Maternal and fetal healthcare
- Gestational Trophoblastic Disease Studies
- Protein Tyrosine Phosphatases
- Prenatal Screening and Diagnostics
- Ureteral procedures and complications
- Reproductive Biology and Fertility
- RNA modifications and cancer
- Pregnancy-related medical research
- Intestinal and Peritoneal Adhesions
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- ATP Synthase and ATPases Research
- Dietary Effects on Health
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Bone Metabolism and Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ion Transport and Channel Regulation
Women's Hospital, School of Medicine, Zhejiang University
2015-2024
Shanghai Tenth People's Hospital
2022-2024
Tongji University
2022-2024
Zhejiang Chinese Medical University
2019
Endometriosis
2019
Creative Commons
2019
American Society for Reproductive Medicine
2019
National Natural Science Foundation of China
2019
Zhejiang University
2002-2015
Ministry of Education of the People's Republic of China
2013
BACKGROUND:Studies have shown that the concentration of interleukin (IL)-6 in peritoneal fluid is increased patients with endometriosis; however, whether disorders involving IL-6 contribute to development endometriosis still unclear. In present study, we evaluated potential role and receptor (IL-6R) pathogenesis endometriosis. MATERIAL AND METHODS:We examined activated macrophages expression membrane-binding (mIL-6R) using flow cytometry. The levels soluble (sIL-6R) plasma was measured by an...
Abstract Mitochondria play a pivotal role in physiological and metabolic function of the cell. Mitochondrial dynamics orchestrate mitochondrial morphology, involving fission fusion as well ultrastructural remodeling. Mounting evidence unravels close link between mitochondria endometriosis. However, how architecture changes through eutopic ectopic tissues women with ovarian endometriosis remains unknown. We detected expression genes morphology endometrium The results showed that DRP1 LCLAT 1...
Abstract Background Endometrial fibrosis, a significant characteristic of intrauterine adhesion (IUA), is caused by the excessive differentiation and activation endometrial stromal cells (ESCs). Glutaminolysis metabolic process glutamine (Gln), which has been implicated in multiple types organ fibrosis. So far, little known about whether glutaminolysis plays role Methods The model ESCs was constructed TGF-β1, followed RNA-sequencing analysis. Changes glutaminase1 (GLS1) expression at RNA...
Glioblastomas are capable of infiltrating into neighboring brain tissues. The prognosis a male patient is worse than that women. Here, we demonstrate the effects estrogen on invasion glioma cells via regulating nuclear receptors (ERα and ERβ) combined with aquaporin 2 (AQP2). In our study, conclude AQP2 was located mainly in nuclei cell lines inhibiting invasion. According to gene ontology analysis, out 138 screened genes, three genes ankyrin repeat FYVE domain containing 1 (
Is phosphatase of regenerating liver-3 (PRL-3) associated with increased motility endometriotic cells from endometrioma?Elevated PRL-3 promotes cytoskeleton reorganization, cell migration and invasion endometrial stromal (ESCs) endometrioma.Overexpression is cancer migration, metastatic phenotype.Primary human ESCs were isolated eutopic endometrium women without endometriosis (EuCo, n = 10), histologically proven endometrioma (EuEM, 19) the cyst wall ovarian (OvEM, 26).The expression in...
The incidence of colorectal cancer (CRC) is increasing in young adults, but knowledge regarding the molecular features sporadic early-onset (SEOCRC) limited. objective present study was to investigate potential key tumorigenesis-associated genes and their regulatory microRNAs (miRNAs) SEOCRC. Using miRNA mRNA expression screening SEOCRC late-onset (SLOCRC) by next generation sequencing (NGS) bioinformatics, SEOCRC-associated miRNAome transcriptome were analyzed. In profiles, miRNAs analyzed...
Endometriosis is generally characterized as a tumor-like disease because of its potential for distant metastasis and local tissue invasion, while whether osteopontin (OPN) plays role in the pathogenesis endometriosis has not been thoroughly investigated. We investigated expression OPN, urokinase plasminogen activator (uPA), phosphatidylinositol 3 kinase (PI3K), phospho-PI3 (p-PI3K) endometrial stromal cells (ESCs). The serum concentration OPN was determined by enzyme-linked immunosorbent...
This study was performed to assess whether prophylactic uterine artery embolization (UAE) is beneficial for second-trimester abortion with complete placenta previa (CPP).Patients CPP who underwent pregnancy termination by labor induction or without UAE from January 2010 2018 were retrospectively reviewed. In total, 25 patients eligible analysis. The primary outcomes the success rate and bleeding volume, secondary induction-to-abortion time, length of hospital stay, complications.CPP occurred...