A5024794754- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Computational Drug Discovery Methods
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Liver physiology and pathology
- Cancer, Hypoxia, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Zhongshan Hospital
2016-2025
Fudan University
2016-2025
Sun Yat-sen University
2016-2025
Fuzhou University
2024-2025
First Affiliated Hospital of Bengbu Medical College
2023-2025
Anhui University of Finance and Economics
2025
Soochow University
2023-2024
Second Affiliated Hospital of Soochow University
2023-2024
Bengbu Medical College
2024
For stage II colon cancer, the efficacy of postoperative adjuvant chemotherapy remains controversial. It is well known that tumor-associated macrophages (TAMs) are important in tumor progression. In this study, TAMs were investigated as prognostic and predictive biomarkers for cancer after radical resection.This study enrolled two independent cohorts consecutive patients from one medical center with pathologic resections. Macrophages detected using IHC staining CD68 CD206. Infiltration...
Tumor purity is defined as the proportion of cancer cells in tumor tissue. The impact on colon (CC) prognosis, genetic profile, and microenvironment has not been thoroughly accessed.Clinical transcriptomic data from three public datasets, GSE17536/17537, GSE39582, TCGA, were retrospectively collected (n=1,248). each sample was inferred by a computational method based data. Survival-related analyses performed microarray dataset containing GSE17536/17537 GSE39582 (n=794), whereas TCGA utilized...
More than 40% of patients with late-stage colorectal cancer (CRC) develop liver metastasis (LM). Which immune cells play important roles in CRC-LM and contribute to the difference between left-sided CRC (LCC) right-sided (RCC) remain unclear. By single-cell RNA sequencing (scRNA-seq), we not only find that activated B are significantly depleted LM, but also a subtype developed from cells, namely immature plasma cell population alpha (iMPA), highly correlated metastasis. Mechanistically,...
Aim: Colorectal cancer (CRC) is the leading cause of associated death worldwide and immune checkpoint blockade therapy only benefit a small set CRC patients. Tumor ferroptosis reflected immune-activation in our previous findings. Understanding mechanisms underlying how to bolster CD8+ T cells function through tumor microenvironment (TME) will greatly immunotherapy. Methods: Genes between cell were screened Cox, WGCNA differential expression analysis. Immunohistochemistry Immunofluorescence...
Abstract How to promote wound healing is still a major challenge in the healthcare while macrophages are critical component of process. Compared various bioactive drugs, many plants have been reported facilitate process by regulating immune response wounds. In this work, Three‐dimensional (3D) printed hydrogel scaffold loaded with natural Centella asiatica extract (CA extract) developed for healing. This CA@3D uses gelatin (Gel) and sodium alginate (SA) CA as bio‐ink 3D printing. The...
Cancer-related mortality in patients with colorectal cancer (CRC) is predominantly caused by development of liver metastases (CLMs). How to screen the sensitive chemotherapy and targeted therapy key element improve prognosis CLMs patients. The study aims develop patient-derived organoids-based xenografted (PDOX-LM) model CRC, recapitulate clinical drug response.We transplanted human CRC primary tumor derived organoids murine spleen obtain liver. Immunohistochemistry (IHC) staining,...
The role of mast cells (MCs) in colorectal cancer (CRC) progression was controversial. Thus, our study designed to evaluate the prognostic value MCs as well their correlation with immune microenvironment. A retrospective cohort CRC patients stages I–IV enrolled study. Consecutive (854) were divided into training set (427 patients) and validation randomly. findings further validated a GEO cohort, GSE39582 (556 patients). cell density (MCD) measured by immunohistochemical staining tryptase or...
Abstract Background and Objectives Robotic surgery for rectal cancer is gaining popularity, but persuasive evidence on reducing surgical trauma still lacking. This study compared robotic laparoscopic abdominoperineal resections (APRs) the risk of postoperative complications in low cancer. Methods Between December 2013 2016, patients with ≤5 cm from anal verge, cT1‐T3 N0‐1, or ycT1‐T3 Nx stage, no distant metastases were enrolled a single‐center, randomized, controlled trial. Eligible...
This study aimed to compare the short-term and long-term outcomes between robotic-assisted simultaneous resection open surgery in patients with rectal cancer liver metastases.Open of colorectal synchronous metastases is widely performed potential cure for eligible patients. However, feasibility robotic primary secondary lesions has not been established as a treatment option metastatic cancer.A single-center randomized controlled trial was conducted at hospital China. Enrolling were aged from...
Hepatic stellate cells (HSCs) are the primary extracellular matrix-producing within liver and have numerous vital functions. A robust protocol for isolation culture of HSCs is important further investigations cell functions related mechanisms in disease. The volume mouse much smaller than that rat liver, which makes it more difficult to isolate (mHSCs) HSCs. At present, isolating mHSCs still a challenge because there no efficient, method these cells. In present study, C57BL/6J mice were...
Type 1 diabetes mellitus is caused by the autoimmune destruction of β cells within islets. In recent years, innate immunity has been proposed to play a key role in this process. High-mobility group box (HMGB1), an inflammatory trigger number diseases, activates proinflammatory responses following its release from necrotic cells. Our aim was determine significance HMGB1 natural history non-obese diabetic (NOD) mice. We observed that rate expression cytoplasm islets much greater mice compared...
The incidence of esophageal adenocarcinoma (EAC) is increasing, but factors contributing to malignant progression its precursor lesion, Barrett's esophagus (BE), have not been defined. Hypergastrinemia caused by long-term use proton pump inhibitors (PPIs), has suggested as one possible risk factor. gastrin receptor, CCK2R, expressed in the cardia and upregulated BE, suggesting involvement gastrin-CCK2R pathway progression. In L2-IL-1β mouse model, Barrett's-like arises from gastric cardia....
177 Background: Surgery is standard of care for pMMR early distal rectal cancer (RC), which can be partially exempted by totally neoadjuvant chemoradiotherapy (TNT) followed watch and wait. But long-term data showed that 1/3 patients had local growth( mostly in the wall)in two years. This study investigates efficacy safety TNT excision( LE) carcinoma (cT1-3N0M0) order to preserve organs. Methods: In this single-arm, phase 2 prospective trial, were eligible if they aged 18 years or older,...
To evaluate precise assessment methods for predicting the optimal acetabular cup size in total hip arthroplasty (THA). A clinical data of 73 patients (80 hips) who underwent primary THA between December 2022 and July 2024 met inclusion criteria was analyzed. There were 39 males 34 females with an average age 66.3 years (range, 56-78 years). Among them, 66 cases unilateral 7 bilateral THAs. 29 (34 osteoarthritis, 35 (35 femoral neck fractures, 9 (11 osteonecrosis head. Based on...
Hepatic stellate cells (HSCs) are important part of the local 'stem cell niche' for hepatic progenitor (HPCs) and hepatocytes. However, it is unclear as to whether products activated HSCs required attenuate hepatocyte injury, enhance liver regeneration, or both. In this study, we performed 'loss function' studies by depleting with gliotoxin. It was demonstrated that a significantly severe damage declined survival rate were correlated depletion HSCs. Furthermore, diminishing HSC activation...
Ribosomal protein S15A (RPS15A), which has been identified as a highly conserved 40S ribosomal protein, is essential for cell survival and proliferation. The present study evaluated the functional role of RPS15A in colorectal cancer (CRC), our investigation found that was expressed cohort human CRC. High expression associated with older age (P=0.035), not receiving preoperative neoadjuvant treatment (P=0.048), higher primary pN stage (P=0.007) slightly more synchronous distant metastases...
Abstract Background The calculation of the tumor burden score (TBS) is not perfect because bilobar spread colorectal liver metastasis (CRLM) neglected. identification an ideal prognostic scoring system for CRLM remains controversial. Materials and Methods Patients who underwent curative intent resection from one medical center were enrolled in cohort 1 (787 patients) 2 (162 patients). Tumor relapse-free survival (RFS) was main outcome. A Cox regression model used to identify independent...
Surgery is the mainstay for treating hepatocellular carcinoma (HCC). However, it a great challenge surgeons to identify HCC in its early developmental stage. The diagnostic sensitivity tiny with diameter less than 1.0 cm usually as low 10–33% computed tomography (CT) and 29–43% magnetic resonance imaging (MRI). Although MRI preferred modality detecting HCC, unparalleled spatial resolution soft tissue, commercially available contrast agent, such Gd3+-DTPA, cannot accurately define because of...