A5053066562- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- T-cell and B-cell Immunology
- Colorectal and Anal Carcinomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Plant Physiology and Cultivation Studies
- Cocoa and Sweet Potato Agronomy
- vaccines and immunoinformatics approaches
- Toxin Mechanisms and Immunotoxins
- Myasthenia Gravis and Thymoma
- Hematopoietic Stem Cell Transplantation
Zhongshan Hospital
2020-2025
Fudan University
2006-2025
The First Affiliated Hospital, Sun Yat-sen University
2020-2025
Sun Yat-sen University
2020-2025
Shanghai Children's Medical Center
2015-2025
Shanghai Jiao Tong University
2011-2025
Chinese PLA General Hospital
2019-2024
Tianjin Medical University
2023-2024
Harbin Institute of Technology
2024
Hangzhou Xixi hospital
2023-2024
Abstract Advanced intrahepatic cholangiocarcinoma (ICC) has a dismal prognosis. Here, we report the efficacy and safety of combining toripalimab, lenvatinib, gemcitabine plus oxaliplatin (GEMOX) as first-line therapy for advanced ICC. Thirty patients with pathologically confirmed ICC received intravenous (1 g/m 2 ) on Days 1 8 (85 mg/m Q3W six cycles along toripalimab (240 mg) oral lenvatinib (8 once daily one year. The expression programmed death-ligand (PD-L1) genetic status was...
Abstract Emotional distress (ED), commonly characterized by symptoms of depression and/or anxiety, is prevalent in patients with cancer. Preclinical studies suggest that ED can impair antitumor immune responses, but few clinical have explored its relationship response to checkpoint inhibitors (ICIs). Here we report results from cohort 1 the prospective observational STRESS-LUNG study, which investigated association between and efficacy first-line treatment ICIs advanced non-small-cell lung...
To assess the effects of bevacizumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) as first-line treatment RAS mutant unresectable colorectal liver metastases.From October 2013 to December 2017, patients with liver-limited metastases from cancer were randomly assigned receive mFOLFOX6 (arm A) or alone B). The resectability was determined by a local multidisciplinary team. primary end point actual rate converted R0 resection for metastases. Secondary points included tumor...
Esophageal squamous cell carcinoma (ESCC) is one of the most refractory malignant tumors. cancer (EC) a tumor with high incidence worldwide, and over 50% EC cases occur in China. Under National Comprehensive Cancer Network (NCCN) guidelines, concurrent chemoradiotherapy only standard neoadjuvant treatment for locally advanced ESCC. In first-line ESCC, efficacy immune checkpoint inhibitors (ICIs) combined systemic chemotherapy significantly better than that alone. Paclitaxel cisplatin (TP),...
Abstract Background Hormone receptor‐positive (HR+)/humaal growth factor receptor 2‐negative (HER2‐) breast cancer, the most common cancer type, has variable prognosis and high recurrence risk. Neoadjuvant therapy is recommended for median‐high risk HR+/HER2‐ patients. This phase II, single‐arm, prospective study aimed to explore appropriate neoadjuvant treatment strategies Methods Eligible female patients with newly diagnosed, untreated received 2 cycles of nab‐paclitaxel carboplatin...
ABSTRACT RNA interference (RNAi) is a powerful tool to silence gene expression posttranscriptionally. In this study, we evaluated the antiviral potential of small interfering (siRNA) targeting VP1 foot-and-mouth disease virus (FMDV), which essential during life cycle and plays key role in attachment susceptible cells. We investigated vivo inhibitory effect VP1-specific siRNAs on FMDV replication BHK-21 cells suckling mice, commonly used animal model. The results showed that transfection...
The increased prevalence of obesity significantly affects human health worldwide. Improvement glycometabolism by dietotherapy/herbal remedy is an effective approach to ameliorate obesity. In this study, high-fat-diet induced obese (DIO) mice were treated with mulberry leaves for 13 weeks. results showed that alleviated adiposity DIO including reducing body weight gain, fat accumulation and fasting blood glucose, improving insulin sensitivity. addition, had protective effects on liver...
The therapeutic efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in advanced EGFR-mutant lung squamous cell carcinoma (SCC) patients remains uncertain. Furthermore, the factors underlying responsiveness have not been fully investigated. We therefore investigated link between genomic profiles and EGFR-TKI efficacy.We consecutively enrolled stage IV, EGFR-mutant, EGFR-TKI-treated with SCC. Patients EGFR wild-type SCC adenocarcinoma were as controls,...
To compare the efficacy and safety of pembrolizumab combined with neoadjuvant chemotherapy (neoCT) versus chemoradiotherapy (neoCRT) followed by surgery for locally advanced resectable oesophageal squamous cell carcinoma (ESCC).This study is a multicentre, prospective, randomized-controlled, phase III clinical study. Eligible ESCC (staging: cT1N2M0 or cT2-3N0-2M0 (stage II/III, high-risk lesions in T2N0M0)) patients will be randomly assigned to either experimental group (pembrolizumab neoCT,...
Abstract Background and Objectives Robotic surgery for rectal cancer is gaining popularity, but persuasive evidence on reducing surgical trauma still lacking. This study compared robotic laparoscopic abdominoperineal resections (APRs) the risk of postoperative complications in low cancer. Methods Between December 2013 2016, patients with ≤5 cm from anal verge, cT1‐T3 N0‐1, or ycT1‐T3 Nx stage, no distant metastases were enrolled a single‐center, randomized, controlled trial. Eligible...
Accurate tumour response prediction to targeted therapy allows for personalised conversion patients with unresectable colorectal cancer liver metastases (CRLM). In this study, we aimed develop and validate a multi-modal deep learning model predict the efficacy of bevacizumab in initially CRLM using baseline PET/CT, clinical data, colonoscopy biopsy specimens.
This study aimed to compare the short-term and long-term outcomes between robotic-assisted simultaneous resection open surgery in patients with rectal cancer liver metastases.Open of colorectal synchronous metastases is widely performed potential cure for eligible patients. However, feasibility robotic primary secondary lesions has not been established as a treatment option metastatic cancer.A single-center randomized controlled trial was conducted at hospital China. Enrolling were aged from...
Foot-and-mouth disease virus (FMDV) infection is responsible for the heavy economic losses in stockbreeding each year. Because of limited effectiveness existing vaccines and antiviral drugs, development new strategies needed. RNA interference (RNAi) an effective means suppressing replication vitro. Here we demonstrate that treatment with recombinant, replication-defective human adenovirus type 5 (Ad5) expressing short-hairpin RNAs (shRNAs) directed against either structural protein 1D...
Common Terminology Criteria for Adverse Events, Version 3.0 (CTCAE v3.0) were released in 2003 and have been used widely to report toxicity publications or presentations describing cancer clinical trials. Here we evaluate whether guidelines reporting are followed randomized trials (RCTs) cancer.Phase III RCTs evaluating systemic therapy published between 2011 2013, reviewed identify eligible studies, which stated explicitly that CTCAE v3.0 was toxicity. Each AE term its grade located...
The hazard ratio (HR) is used routinely to quantify the treatment effect for time-to-event end points in oncology trials, but its use requires that there be proportional hazards arms. Non-proportional are observed frequently cancer immunotherapy trials due long-term survival and delayed clinical effect. Although values of HR quoted such they not valid measures outcome.Reports parallel group randomized controlled (RCTs) evaluating immune checkpoint inhibitors with overall data were eligible....
Macrophages are known to support cardiac development and homeostasis, contributing tissue remodeling repair in the adult heart. However, it remains unclear whether embryonic macrophages also respond abnormalities developing Previously, we reported that structural protein Sorbs2 promotes of second heart field, with its deficiency resulting atrial septal defects (ASD). In analyzing RNA-seq data, noted an upregulation macrophage-related genes -/- hearts. Immunostaining lineage-tracing confirmed...